Display Settings:

Format

Send to:

Choose Destination

EPHA2 EPH receptor A2 [ Homo sapiens (human) ]

Gene ID: 1969, updated on 7-Dec-2014
Official Symbol
EPHA2provided by HGNC
Official Full Name
EPH receptor A2provided by HGNC
Primary source
HGNC:HGNC:3386
See related
Ensembl:ENSG00000142627; HPRD:01494; MIM:176946; Vega:OTTHUMG00000009527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ECK; CTPA; ARCC2; CTPP1; CTRCT6
Summary
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]
See EPHA2 in Epigenomics, MapViewer
Location:
1p36
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (16124337..16156087, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (16450832..16482582, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chloride channel, voltage-sensitive Kb Neighboring gene family with sequence similarity 131, member C Neighboring gene uncharacterized LOC101927479 Neighboring gene Rho guanine nucleotide exchange factor (GEF) 19 Neighboring gene anoctamin 7 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Cataract 6
MedGen: C1861825 OMIM: 116600 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog
  • Arf6 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 signaling events, organism-specific biosystem
    Arf6 signaling events
  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
    Direct p53 effectors, organism-specific biosystem
    Direct p53 effectors
  • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
    EPH-Ephrin signaling, organism-specific biosystemDuring the development process cell migration and adhesion are the main forces involved in morphing the cells into critical anatomical structures. The ability of a cell to migrate to its correct dest...
  • EPH-ephrin mediated repulsion of cells, organism-specific biosystem (from REACTOME)
    EPH-ephrin mediated repulsion of cells, organism-specific biosystemDespite high-affinity multimeric interaction between EPHs and ephrins (EFNs), the cellular response to EPH-EFN engagement is usually repulsion between the two cells and signal termination. These repu...
  • EPHA forward signaling, organism-specific biosystem (from Pathway Interaction Database)
    EPHA forward signaling, organism-specific biosystem
    EPHA forward signaling
  • EPHA-mediated growth cone collapse, organism-specific biosystem (from REACTOME)
    EPHA-mediated growth cone collapse, organism-specific biosystemEPH/Ephrin signaling is coupled to Rho family GTPases such as Rac, Rho and Cdc42 that connect bidirectional receptor-ligand interactions to changes in the actin cytoskeleton (Noren & Pasquale 2004, G...
  • EPHA2 forward signaling, organism-specific biosystem (from Pathway Interaction Database)
    EPHA2 forward signaling, organism-specific biosystem
    EPHA2 forward signaling
  • EphrinA-EPHA pathway, organism-specific biosystem (from Pathway Interaction Database)
    EphrinA-EPHA pathway, organism-specific biosystem
    EphrinA-EPHA pathway
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem (from Pathway Interaction Database)
    Stabilization and expansion of the E-cadherin adherens junction, organism-specific biosystem
    Stabilization and expansion of the E-cadherin adherens junction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
activation of Rac GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
axial mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
bone remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
branching involved in mammary gland duct morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lens fiber cell morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
mammary gland epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organismal development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
neural tube development IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
notochord cell development IEA
Inferred from Electronic Annotation
more info
 
notochord formation IEA
Inferred from Electronic Annotation
more info
 
osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of establishment of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-anal tail morphogenesis IEA
Inferred from Electronic Annotation
more info
 
protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of blood vessel endothelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell adhesion mediated by integrin IDA
Inferred from Direct Assay
more info
PubMed 
regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to growth factor IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal system development IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium membrane IEA
Inferred from Electronic Annotation
more info
 
leading edge membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
ruffle membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
ephrin type-A receptor 2
Names
ephrin type-A receptor 2
soluble EPHA2 variant 1
tyrosine-protein kinase receptor ECK
epithelial cell receptor protein tyrosine kinase
NP_004422.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021396.1 

    Range
    5001..36751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004431.3NP_004422.2  ephrin type-A receptor 2 precursor

    See proteins identical to NP_004422.2

    Status: REVIEWED

    Source sequence(s)
    AI302504, AL451042, BC037166, CB991812
    Consensus CDS
    CCDS169.1
    UniProtKB/TrEMBL
    A0A024QZA8
    UniProtKB/Swiss-Prot
    P29317
    Related
    ENSP00000351209, OTTHUMP00000011117, ENST00000358432, OTTHUMT00000026322
    Conserved Domains (8) summary
    cd05063
    Location:607875
    PTKc_EphR_A2; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2
    cd09543
    Location:902971
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    smart00454
    Location:902968
    SAM; Sterile alpha motif
    cd10480
    Location:28201
    EphR_LBD_A2; Ligand Binding Domain of Ephrin type-A Receptor 2
    cd00063
    Location:439526
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00185
    Location:258326
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
    pfam07714
    Location:613871
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:556610
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    16124337..16156087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005245752.1XP_005245809.1  

    Conserved Domains (8) summary
    cd05063
    Location:553821
    PTKc_EphR_A2; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2
    cd09543
    Location:848917
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    smart00454
    Location:848914
    SAM; Sterile alpha motif
    cd00063
    Location:385472
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00185
    Location:204272
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
    pfam07714
    Location:559817
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:502556
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1147
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  2. XM_005245751.2XP_005245808.1  

    Conserved Domains (8) summary
    cd05063
    Location:596864
    PTKc_EphR_A2; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2
    cd09543
    Location:891960
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    smart00454
    Location:891957
    SAM; Sterile alpha motif
    cd10480
    Location:18190
    EphR_LBD_A2; Ligand Binding Domain of Ephrin type-A Receptor 2
    cd00063
    Location:428515
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00185
    Location:247315
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
    pfam07714
    Location:602860
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:545599
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    16249454..16281203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    14968749..15000153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)