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PAOX polyamine oxidase (exo-N4-amino) [ Homo sapiens (human) ]

Gene ID: 196743, updated on 12-May-2016
Official Symbol
PAOXprovided by HGNC
Official Full Name
polyamine oxidase (exo-N4-amino)provided by HGNC
Primary source
HGNC:HGNC:20837
See related
Ensembl:ENSG00000148832 HPRD:10136; MIM:615853; Vega:OTTHUMG00000019318
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAO
Orthologs
Location:
10q26.3
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (133379237..133391696)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135192741..135205198)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene fucose mutarotase Neighboring gene enoyl-CoA hydratase, short chain, 1, mitochondrial Neighboring gene microRNA 3944 Neighboring gene mitochondrial ribosome associated GTPase 1 Neighboring gene shadow of prion protein homolog (zebrafish) Neighboring gene olfactory receptor family 6 subfamily L member 2 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
  • Amine Oxidase reactions, organism-specific biosystem (from REACTOME)
    Amine Oxidase reactions, organism-specific biosystemHuman amine oxidases (AO) catalyze the oxidative deamination of biogenic amines (neurotransmitters such as serotonin, noradrenaline, the hormone adrenaline and polyamines such as the spermines) and x...
  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Interconversion of polyamines, organism-specific biosystem (from REACTOME)
    Interconversion of polyamines, organism-specific biosystemThe reactions catalyzed by aminopropyl-transferases annotated above are generally irreversible. But spermine and spermidine can be recycled respectively into spermidine and putrescine. These events r...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • Metabolism of polyamines, organism-specific biosystem (from REACTOME)
    Metabolism of polyamines, organism-specific biosystemPolyamines is a family of molecules (i.e. putrescine, spermine, spermidine) derived from ornithine according to a decarboxylation/condensative process. More recently, it has been demonstrated that ar...
  • PAOs oxidise polyamines to amines, organism-specific biosystem (from REACTOME)
    PAOs oxidise polyamines to amines, organism-specific biosystemPolyamine oxidases (PAOs), like MAOs, are also FAD-dependant and form aldehydes and hydrogen peroxide. PAOs are approximately 60KDa in size, are monomers and are located in peroxisomes. They act on e...
  • Peroxisome, organism-specific biosystem (from KEGG)
    Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Peroxisome, conserved biosystem (from KEGG)
    Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
    Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...
  • spermine and spermidine degradation I, organism-specific biosystem (from BIOCYC)
    spermine and spermidine degradation I, organism-specific biosystemGeneral Background Polyamines such as : SPERMINE and : SPERMIDINE are required for normal cellular function through their interaction with cellular macromolecules. They are critical regulators of c...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: MTG1

Homology

Clone Names

  • MGC45464, DKFZp434J245

Gene Ontology Provided by GOA

Process Evidence Code Pubs
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
polyamine biosynthetic process TAS
Traceable Author Statement
more info
 
polyamine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of spermidine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
putrescine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
putrescine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
spermidine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
spermine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
peroxisomal matrix TAS
Traceable Author Statement
more info
 
Preferred Names
peroxisomal N(1)-acetyl-spermine/spermidine oxidase
Names
peroxisomal N1-acetyl-spermine/spermidine oxidase
NP_690875.1
NP_997010.1
NP_997011.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152911.3NP_690875.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 1

    See identical proteins and their annotated locations for NP_690875.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA280165, AF312698, BC032778, BE646315
    Consensus CDS
    CCDS7683.1
    UniProtKB/Swiss-Prot
    Q6QHF9
    Related
    ENSP00000278060, OTTHUMP00000020806, ENST00000278060, OTTHUMT00000051146
    Conserved Domains (2) summary
    PLN02568
    Location:14497
    PLN02568; polyamine oxidase
    pfam13450
    Location:4387
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  2. NM_207127.2NP_997010.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 2

    See identical proteins and their annotated locations for NP_997010.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two exons in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA280165, AF312698, AY541514, AY541519, BC032778
    Consensus CDS
    CCDS7684.1
    UniProtKB/Swiss-Prot
    Q6QHF9
    Related
    ENSP00000435514, OTTHUMP00000233408, ENST00000480071, OTTHUMT00000390367
    Conserved Domains (2) summary
    PLN02568
    Location:14297
    PLN02568; polyamine oxidase
    pfam13450
    Location:4387
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
  3. NM_207128.2NP_997011.1  peroxisomal N(1)-acetyl-spermine/spermidine oxidase isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon in the 3' coding region, resulting in a frameshift, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA280165, AF312698, BC032778, BE646315
    Consensus CDS
    CCDS7682.1
    UniProtKB/Swiss-Prot
    Q6QHF9
    Related
    ENSP00000349847, OTTHUMP00000233406, ENST00000357296, OTTHUMT00000390365
    Conserved Domains (2) summary
    PLN02568
    Location:14400
    PLN02568; polyamine oxidase
    pfam13450
    Location:4387
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RNA

  1. NR_109763.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate exon in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA280165, AF312698, AY541513, AY541519, BC032778
  2. NR_109764.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) includes an alternate exon in the 5' coding region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA280165, AF312698, AY541518, AY541519, BC032778
    Related
    ENST00000476834, OTTHUMT00000280390
  3. NR_109765.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) lacks two alternate internal exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA280165, AF312698, AY541517, BC032778
    Related
    ENST00000483211, OTTHUMT00000280389
  4. NR_109766.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks three internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA280165, AF312698, AY541514, AY541519, BC032778
    Related
    ENST00000529585, OTTHUMT00000390366

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    133379237..133391696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    135474601..135487058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_207125.1: Suppressed sequence

    Description
    NM_207125.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_207126.1: Suppressed sequence

    Description
    NM_207126.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  3. NM_207129.1: Suppressed sequence

    Description
    NM_207129.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.