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    Rb1 retinoblastoma 1 [ Mus musculus (house mouse) ]

    Gene ID: 19645, updated on 12-May-2013
    Official Symbol
    Rb1provided by MGI
    Official Full Name
    retinoblastoma 1provided by MGI
    Primary source
    MGI:97874
    See related
    Ensembl:ENSMUSG00000022105; Vega:OTTMUSG00000036132
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rb; pRb; Rb-1
    Location :
    14 D3; 14 38.73 cM
    Sequence :
    Chromosome: 14; NC_000080.6 (73195502..73325791, complement)
    See Rb1 in Epigenomics, MapViewer

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene cysteinyl leukotriene receptor 2 Neighboring gene regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 Neighboring gene microRNA 687 Neighboring gene lysophosphatidic acid receptor 6 Neighboring gene predicted gene, 20290 Neighboring gene integral membrane protein 2B Neighboring gene predicted gene 4266

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer. Youn JI, et al. Nat Immunol, 2013 Mar. PMID 23354483.
    2. Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia. Sawai CM, et al. Cancer Cell, 2012 Oct 16. PMID 23079656.
    3. The retinoblastoma protein is essential for survival of postmitotic neurons. Andrusiak MG, et al. J Neurosci, 2012 Oct 17. PMID 23077065.
    4. Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesis. Song H, et al. Proc Natl Acad Sci U S A, 2012 Oct 23. PMID 23047698.
    5. Differentiation-associated microRNAs antagonize the Rb-E2F pathway to restrict proliferation. Marzi MJ, et al. J Cell Biol, 2012 Oct 1. PMID 23027903.

    See all (613) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The loss of Rb1 leads to the rapid degeneration of most retinal cells except horizontal cells, which persist as giant cells with aberrant centrosome content, DNA damage, and polyploidy/aneuploidy.
      Title: Retinal horizontal cells lacking Rb1 sustain persistent DNA damage and survive as polyploid giant cells.
    2. The transcriptional regulation via Rb-E2F and posttranscriptional regulation via miRNAs-confers robustness to cell cycle control and provides a molecular basis to understand the role of miRNA subversion in cancer.
      Title: Differentiation-associated microRNAs antagonize the Rb-E2F pathway to restrict proliferation.
    3. Inactivation of retinoblastoma protein results in ectopic cell cycle protein expression and neuronal loss.
      Title: The retinoblastoma protein is essential for survival of postmitotic neurons.
    4. Distinct developmental expression patterns is found for individual ppRb isoforms in dental epithelial and dental mesenchymal cell differentiation, suggesting discrete functions in tooth development.
      Title: Discrete phosphorylated retinoblastoma protein isoform expression in mouse tooth development.
    5. RB mutation is associated with drug sensitivity in glioblastoma.
      Title: p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells.
    6. identify a causal role for E2F7 in cellular senescence and uncover a novel link between the RB and p53 pathways.
      Title: The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence.
    7. Rb/E2F is required to coordinate the transition between proliferation and differentiation by controlling key aspects of differentiation through regulation of the Dlx1/Dlx2 bigene cluster.
      Title: The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster.
    8. The degree of Rb phosphorylation and its binding with E2F, in terms of Cdk5-activity.
      Title: Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neurons.
    9. observed reduced N-cadherin expression in RB1(-/-) calvarial osteoblasts
      Title: Loss of the retinoblastoma tumor suppressor protein in murine calvaria facilitates immortalization of osteoblast-adipocyte bipotent progenitor cells characterized by low expression of N-cadherin.
    10. in various tumors types, there is an inverse correlation between the expression levels of gamma-tubulin and RB1 and that in tumor cell lines with a nonfunctioning RB1, reduction of gamma-tubulin protein levels leads to induction of apoptosis.
      Title: Tumors with nonfunctional retinoblastoma protein are killed by reduced γ-tubulin levels.
    Submit: New GeneRIF Correction See all (225)
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description
    NP_033055.1 NP_058036.1 Cdk2    BIND  PubMed CDK2 isoform 2 bound to D-type cyclin phosphorylates pRb. 
    NP_033055.1 NP_904326.1 Cdk2    BIND  PubMed CDK2 isoform 1 bound to D-type cyclin phosphorylates pRb. 
    NP_033055.1 Cdk2    BIND  PubMed CDK2 interacts and phosphorylates Rb. This interaction was modelled on a demonstrated interaction between mouse CDK2 and Rb from unspecified species. 
    NP_033055.1 NP_034000.1 Cdk4    BIND  PubMed Cdk4 interacts with pRb. 
    NP_033055.1 NP_034000.1 Cdk4    BIND  PubMed Cdk4 bound to D-type cyclin phosphorylates pRb. 
    NP_033055.1 NP_034000.1 Cdk4    BIND  PubMed CDK4 interacts and phosphorylates Rb. This interaction was modelled on a demonstrated interaction between mouse CDK4 and Rb from unspecified species. 
    NP_033055.1 AAF07196.1 Cenpf    BIND  PubMed Cenpf (LEK1) interacts with Rb. 
    NP_033055.1 XP_129658.5 Cenpf    BIND  PubMed LEK1 interacts with pRB. 
    NP_033055.1 NP_034626.1 Id2    BIND  PubMed Id2 interacts with pRb. 
    NP_033055.1 NP_035024.1 Neurod1    BIND  PubMed Rb interacts with NeuroD1. 
    NP_033055.1 NC_000078.1 Pomc    BIND  PubMed Rb interacts with the POMC promoter. 
    NP_033055.1 AAB49620.1 Rbbp6    BIND  PubMed Rb interacts with PACT. 
    NP_033055.1 AAB82419.1 Runx2    BIND  PubMed pRb interacts with CBFA1. 
    NP_033055.1 NP_659120.2 Suv420h1    BIND  PubMed RB1 interacts with Suv420h1. 
    NP_033055.1 AAT00540.1 Suv420h2    BIND  PubMed RB1 interacts with Suv4-20h2. 
    NP_033055.1 AC084823.11     BIND  PubMed Rb interacts with MCM5 promoter. 
    NP_033055.1 AJ132779.1     BIND  PubMed Rb interacts with p107 promoter. 
    NP_033055.1 U69555.1     BIND  PubMed Rb interacts with CDC2 promoter. 
    BioGRID:202815 BioGRID:107452 CDK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:202815 BioGRID:107454 CDK4    BioGRID  PubMed Biochemical Activity 
    BioGRID:202815 BioGRID:107841 CSNK2A1    BioGRID  PubMed Biochemical Activity 
    BioGRID:202815 BioGRID:198548 Ccnd1    BioGRID  PubMed Biochemical Activity 
    BioGRID:202815 BioGRID:198644 Cdk2    BioGRID  PubMed Biochemical Activity 
    BioGRID:202815 BioGRID:198645 Cdk4    BioGRID  PubMed Biochemical Activity 
    BioGRID:202815 BioGRID:198649 Cdk6    BioGRID  PubMed Biochemical Activity 
    BioGRID:202815 BioGRID:223714 Cdk9    BioGRID  PubMed Biochemical Activity 
    BioGRID:202815 BioGRID:198652 Cdkn1b    BioGRID  PubMed Biochemical Activity 
    BioGRID:202815 BioGRID:198667 Cebpa    BioGRID  PubMed Reconstituted Complex 
    BioGRID:202815 BioGRID:198669 Cebpb    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:202815 BioGRID:198670 Cebpd    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:202815 BioGRID:199350 E2f1    BioGRID  PubMed Two-hybrid 
    BioGRID:202815 BioGRID:232447 E2f2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:202815 BioGRID:108893 GATA1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:202815 BioGRID:241423 Hdac1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:202815 BioGRID:200340 Hmga1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:202815 BioGRID:200341 Hmga2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:202815 BioGRID:200506 Id2    BioGRID  PubMed Two-hybrid 
    BioGRID:202815 BioGRID:200866 Jarid2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:202815 BioGRID:204126 Morf4l1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:202815 BioGRID:212280 Mrfap1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:202815 BioGRID:201733 Neurod1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:202815 BioGRID:172796 PPP1CA    BioGRID  PubMed Two-hybrid 
    BioGRID:202815 BioGRID:202029 Pax2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:202815 BioGRID:202337 Ppp1cc    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:202815 BioGRID:200422 Prmt2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:202815 BioGRID:207302 Psmd10    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:202815 BioGRID:208328 Rbak    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:202815 BioGRID:198518 Runx2    BioGRID  PubMed Two-hybrid 
    BioGRID:202815 BioGRID:203336 Smarca4    BioGRID  PubMed Two-hybrid 
    BioGRID:202815 BioGRID:230441 Suv420h1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:202815 BioGRID:231299 Suv420h2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:202815 BioGRID:113011 TP53BP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:202815 BioGRID:204020 Ubtf    BioGRID  PubMed Co-fractionation 
    BioGRID:202815 BioGRID:127806 ZFPM1    BioGRID  PubMed Affinity Capture-Western 
    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classes of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compos...
    • Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
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    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
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    • Bladder cancer, organism-specific biosystem (from KEGG)
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    • Bladder cancer, conserved biosystem (from KEGG)
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    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle signaling pathway, organism-specific biosystem (from LIPID MAPS)
      Cell cycle signaling pathway, organism-specific biosystem
      Cell cycle signaling pathway
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
      Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
      Cyclin D associated events in G1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
      Cyclin E associated events during G1/S transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • E2F mediated regulation of DNA replication, organism-specific biosystem (from REACTOME)
      E2F mediated regulation of DNA replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
      Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • Epstein-Barr virus infection, conserved biosystem (from KEGG)
      Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
    • FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
      FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • G1 Phase, organism-specific biosystem (from REACTOME)
      G1 Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hepatitis B, organism-specific biosystem (from KEGG)
      Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
    • IL-6 signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-6 signaling Pathway, organism-specific biosystem
      IL-6 signaling Pathway
    • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-7 Signaling Pathway, organism-specific biosystem
      IL-7 Signaling Pathway
    • Id Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Id Signaling Pathway, organism-specific biosystemInhibitor of DNA binding (ID) proteins are members of the helix-loop-helix (HLH) family of proteins which lack a DNA binding domain themselves but bind to other family members inhibiting their DNA bi...
    • Inhibition of replication initiation of damaged DNA by RB1/E2F1, organism-specific biosystem (from REACTOME)
      Inhibition of replication initiation of damaged DNA by RB1/E2F1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
      Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Non-small cell lung cancer, conserved biosystem (from KEGG)
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    • Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
      Orc1 removal from chromatin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
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    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
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    • Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes, organism-specific biosystem (from REACTOME)
      Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
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    • Regulation of DNA replication, organism-specific biosystem (from REACTOME)
      Regulation of DNA replication, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
      Removal of licensing factors from origins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
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    • Small cell lung cancer, organism-specific biosystem (from KEGG)
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    • Small cell lung cancer, conserved biosystem (from KEGG)
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    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
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    • Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
      Switching of origins to a post-replicative state, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Synthesis of DNA, organism-specific biosystem (from REACTOME)
      Synthesis of DNA, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem
      TGF-beta Receptor Signaling Pathway
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
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    • miRNA regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
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    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA polymerase II activating transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		  
    core promoter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell cycle arrest IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    cell morphogenesis involved in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enucleate erythrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    maintenance of mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    negative regulation of transcription involved in G1/S phase of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		  
    negative regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of transcription, DNA-dependent ISO
    Inferred from Sequence Orthology
    more info
    		  
    neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    neuron maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of macrophage differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein localization to chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of cohesin localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of lipid kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    sister chromatid biorientation ISO
    Inferred from Sequence Orthology
    more info
    		  
    skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		  
    striated muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    Rb-E2F complex IDA
    Inferred from Direct Assay
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Preferred Names
    retinoblastoma-associated protein
    Names
    retinoblastoma-associated protein
    pp105

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009029.2 → NP_033055.2  retinoblastoma-associated protein

      Status: PROVISIONAL

      Source sequence(s)
      BC096525
      Consensus CDS
      CCDS27267.1
      UniProtKB/Swiss-Prot
      P13405
      Related
      ENSMUSP00000022701, OTTMUSP00000051423, ENSMUST00000022701, OTTMUST00000092874
      Conserved Domains (4) summary
      pfam08934
      Location:761 – 920
      Blast Score: 698
      Rb_C; Rb C-terminal domain
      pfam11934
      Location:108 – 222
      Blast Score: 309
      DUF3452; Domain of unknown function (DUF3452)
      pfam01858
      Location:367 – 567
      Blast Score: 731
      RB_A; Retinoblastoma-associated protein A domain
      cl00050
      Location:638 – 759
      Blast Score: 458
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p1 C57BL/6J

      Range
      73195502..73325791, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000036.1 Alternate Mm_Celera

      Range
      70715843..70870859, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01115156.1 None
    genomic AAHY01115157.1 None
    genomic AAHY01115158.1 None
    genomic AAHY01115159.1 None
    genomic AAHY01115160.1 None
    genomic AAHY01115161.1 None
    genomic AAHY01115162.1 (49890..64454) None
    genomic AC154718.2 None
    genomic CH466535.2 EDL35859.1 mixed
    genomic CT571265.12 (171286..206513) None
    genomic M86180.1 None
    mRNA AK011246.1 BAB27493.3 C57BL/6J
    mRNA AK132875.1 BAE21400.1 C57BL/6J
    mRNA AK141028.1 BAE24548.1 C57BL/6J
    mRNA AK146467.1 BAE27194.1 C57BL/6J
    mRNA AK148403.1 BAE28533.1 C57BL/6J
    mRNA AK204056.1 None
    mRNA BC096525.1 AAH96525.1 C57BL/6
    mRNA DQ400415.1 ABD72475.1
    mRNA M26391.1 AAA39964.1 BALB/c
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13405.2 GenPept UniProtKB/Swiss-Prot:P13405

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioAssays, RNAi Target,Active
        BioAssays, RNAi Target,Active
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • Books
        Links between Entrez Gene and 'Books' are established if a GeneID is explicitly referenced in a book.
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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