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DNAH10 dynein axonemal heavy chain 10 [ Homo sapiens (human) ]

Gene ID: 196385, updated on 12-May-2016
Official Symbol
DNAH10provided by HGNC
Official Full Name
dynein axonemal heavy chain 10provided by HGNC
Primary source
HGNC:HGNC:2941
See related
Ensembl:ENSG00000197653 HPRD:13473; HPRD:13477; MIM:605884; Vega:OTTHUMG00000154477
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH10 is an inner arm dynein heavy chain (Maiti et al., 2000 [PubMed 11175280]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
12q24.31
Exon count:
79
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (123761133..123935720)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (124246786..124420267)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370042 Neighboring gene tectonic family member 2 Neighboring gene ATPase H+ transporting V0 subunit a2 Neighboring gene ribosomal protein L27 pseudogene 12 Neighboring gene uncharacterized LOC105370044 Neighboring gene uncharacterized LOC105370043 Neighboring gene filamin-interacting protein FAM101A Neighboring gene coiled-coil domain containing 92 Neighboring gene zinc finger protein 664

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
NHGRI GWA Catalog
  • Huntington's disease, organism-specific biosystem (from KEGG)
    Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
  • Huntington's disease, conserved biosystem (from KEGG)
    Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ38262, FLJ43486, FLJ43808, KIAA2017

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
microtubule-based movement IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cilium IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
dynein complex IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
dynein heavy chain 10, axonemal
Names
axonemal beta dynein heavy chain 10
ciliary dynein heavy chain 10
dynein, axonemal, heavy chain 10
dynein, axonemal, heavy polypeptide 10

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207437.3NP_997320.2  dynein heavy chain 10, axonemal

    See identical proteins and their annotated locations for NP_997320.2

    Status: VALIDATED

    Source sequence(s)
    AB290168, AC079315, AC117503, AL046294, DV080260, DV080609
    Consensus CDS
    CCDS9255.2
    UniProtKB/Swiss-Prot
    Q8IVF4
    UniProtKB/TrEMBL
    B0I1S1
    Related
    ENSP00000386770, OTTHUMP00000205777, ENST00000409039, OTTHUMT00000335420
    Conserved Domains (7) summary
    cd00009
    Location:24482559
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam12777
    Location:30453378
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:33983628
    AAA_9; ATP-binding dynein motor region D5
    pfam03028
    Location:37574469
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:241759
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:12561663
    DHC_N2; Dynein heavy chain, N-terminal region 2
    cl21455
    Location:17942022
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    123761133..123935720
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538016.1XP_011536318.1  

    Conserved Domains (7) summary
    cd00009
    Location:25662677
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam12777
    Location:31003433
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34533683
    AAA_9; ATP-binding dynein motor region D5
    pfam03028
    Location:38124524
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:302877
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13741781
    DHC_N2; Dynein heavy chain, N-terminal region 2
    cl21455
    Location:19122140
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_011538013.1XP_011536315.1  

    Conserved Domains (7) summary
    cd00009
    Location:25662677
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam12777
    Location:31603493
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:35133743
    AAA_9; ATP-binding dynein motor region D5
    pfam03028
    Location:38724584
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:302877
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13741781
    DHC_N2; Dynein heavy chain, N-terminal region 2
    cl21455
    Location:19122140
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  3. XM_011538014.1XP_011536316.1  

    Conserved Domains (7) summary
    cd00009
    Location:25132624
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam12777
    Location:31103443
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34633693
    AAA_9; ATP-binding dynein motor region D5
    pfam03028
    Location:38224534
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:302877
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13741781
    DHC_N2; Dynein heavy chain, N-terminal region 2
    cl21455
    Location:19122140
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. XM_011538015.1XP_011536317.1  

    Conserved Domains (7) summary
    cd00009
    Location:25032614
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam12777
    Location:31003433
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34533683
    AAA_9; ATP-binding dynein motor region D5
    pfam03028
    Location:38124524
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:302877
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13741781
    DHC_N2; Dynein heavy chain, N-terminal region 2
    cl21455
    Location:28213088
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  5. XM_011538017.1XP_011536319.1  

    Conserved Domains (7) summary
    cd00009
    Location:24542565
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam12777
    Location:30513384
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:34043634
    AAA_9; ATP-binding dynein motor region D5
    pfam03028
    Location:37634475
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:302877
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13741781
    DHC_N2; Dynein heavy chain, N-terminal region 2
    cl21455
    Location:27723039
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. XM_011538020.1XP_011536322.1  

    Conserved Domains (3) summary
    pfam08385
    Location:302877
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13741781
    DHC_N2; Dynein heavy chain, N-terminal region 2
    cl21455
    Location:19122140
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  7. XM_005253555.2XP_005253612.1  

    Conserved Domains (7) summary
    cd00009
    Location:25662677
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam12777
    Location:31633496
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:35163746
    AAA_9; ATP-binding dynein motor region D5
    pfam03028
    Location:38754587
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:302877
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13741781
    DHC_N2; Dynein heavy chain, N-terminal region 2
    cl21455
    Location:19122140
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  8. XM_011538018.1XP_011536320.1  

    Conserved Domains (6) summary
    cd00009
    Location:17381849
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam12777
    Location:23352668
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:26882918
    AAA_9; ATP-binding dynein motor region D5
    pfam03028
    Location:30473759
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:546953
    DHC_N2; Dynein heavy chain, N-terminal region 2
    cl21455
    Location:10841312
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  9. XM_011538019.1XP_011536321.1  

    Conserved Domains (6) summary
    cd00009
    Location:15131624
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    pfam12777
    Location:21102443
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:24632693
    AAA_9; ATP-binding dynein motor region D5
    pfam03028
    Location:28223534
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08393
    Location:321728
    DHC_N2; Dynein heavy chain, N-terminal region 2
    cl21455
    Location:8591087
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_187590.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    177..109264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    124067935..124240960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)