AHR aryl hydrocarbon receptor [Homo sapiens] - Gene

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Summary

Official Symbol: AHRprovided by HGNC
Official Full Name: aryl hydrocarbon receptorprovided by HGNC
Primary source: HGNC:348
See related: Ensembl:ENSG00000106546; HPRD:02596; MIM:600253; Vega:OTTHUMG00000149967
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: bHLHe76
Summary: This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 7p15

Sequence :: Chromosome: 7; NC_000007.13 (17338276..17385775)

See AHR in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Highlight the importance of cross-regulation between AhR and ERalpha and a novel mechanism by which AhR controls, through modulating the recruitment of RIP140 to ERalpha-binding sites, the kinetics and magnitude of ERalpha-mediated gene stimulation.
Title: Aryl hydrocarbon receptor modulation of estrogen receptor α-mediated gene regulation by a multimeric chromatin complex involving the two receptors and the coregulator RIP140.
the specific functions of AHR and ARNT in estrogen-dependent signaling
Title: Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines.
our data demonstrated that AhR protected lung adenocarcinoma cells against cigarette sidestream smoke particulate-induced oxidative stress and promoted post-exposure clonogenicity
Title: Aryl hydrocarbon receptor protects lung adenocarcinoma cells against cigarette sidestream smoke particulates-induced oxidative stress.
Data show that aryl hydrocarbon receptor (AhR) activation suppressed mammosphere formation of MCF-7 cells and decreased the proportion of cells with high aldehyde dehydrogenase 1 (ALDH-1) activity.
Title: Activation of the aryl hydrocarbon receptor represses mammosphere formation in MCF-7 cells.
Present data demonstrate for the first time that activation of the AhR by TCDD suppressed the development of Th2-mediated food allergic responses.
Title: Activation of the aryl hydrocarbon receptor suppresses sensitization in a mouse peanut allergy model.
tryptophan catabolite kynurenine is an endogenous ligand of the human AHR that is constitutively generated by human tumour cells via tryptophan-2,3-dioxygenase, a liver- and neuron-derived Trp-degrading enzyme not yet implicated in cancer biology
Title: An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor.
The polymorphism of aryl hydrocarbon receptor G1661A has no significant impact on levels of urinary 1-hydroxypyrene in coke oven workers.
Title: [Relationship between aryl hydrocarbon receptor G1661A gene polymorphism and level of urinary 1-hydroxypyrene of coke oven workers].
results demonstrate that SULT1E1 expression in MCF10A breast epithelial cells cells is transcriptionally regulated by confluence through a suppressive action of the AhR, which is not mediated through a dioxin response element at nt -3476
Title: Regulation of estrogen sulfotransferase expression by confluence of MCF10A breast epithelial cells: role of the aryl hydrocarbon receptor.
The homozygote variant genotype of AHR Lys554Lys is associated with a significantly lower AHR, ARNT and CYP1B1 mRNA expression.
Title: RNA expressions of AHR, ARNT and CYP1B1 are influenced by AHR Arg554Lys polymorphism.
The expression of AhR mRNA in PBMCs and IL-22 protein in plasma of patients with allergic asthma were higher than those in controlled asthma cases.
Title: Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma.

Submit: New GeneRIF Correction See all (176)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.

Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption.

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001612.1	NP_001659.1	ARNT	BIND	PubMed	Arnt interacts with AhR.
NP_001612.1	NP_003734.3	NCOA1	BIND	PubMed	AHR interacts with NCOA1 (SRC-1a).
NP_001612.1	NP_006531.1	NCOA2	BIND	PubMed	AHR interacts with NCOA2 (TIF2).
NP_001612.1	NP_003176.1	TAF4	BIND	PubMed	AHR interacts with TAF4.
NP_001612.1		TAF6	BIND	PubMed	AHR interacts with TAF6.
NP_001612.1	NP_003185.1	TBP	BIND	PubMed	AHR interacts with TBP.
P35869	P35869	AHR	HPRD	PubMed
P35869	O00170	AIP	HPRD	PubMed
P35869	P10275	AR	HPRD	PubMed
P35869	P27540	ARNT	HPRD	PubMed
P35869	O00327	ARNTL	HPRD	PubMed
P35869	O60563	CCNT1	HPRD	PubMed
P35869	Q13620	CUL4B	HPRD	PubMed
P35869	P51398	DAP3	HPRD	PubMed
P35869	Q09472	EP300	HPRD	PubMed
P35869	P03372	ESR1	HPRD	PubMed
P35869	P13984	GTF2F2	HPRD	PubMed
P35869	P07900	HSP90AA1	HPRD	PubMed
P35869	Q15788	NCOA1	HPRD	PubMed
P35869	Q15596	NCOA2	HPRD	PubMed
P35869	Q9Y618	NCOR2	HPRD	PubMed
P35869	Q15843	NEDD8	HPRD	PubMed
P35869	P10589	NR2F1	HPRD	PubMed
P35869	P48552	NRIP1	HPRD	PubMed
P35869	Q15185	PTGES3	HPRD	PubMed
P35869	P06400	RB1	HPRD	PubMed
P35869	Q04206	RELA	HPRD	PubMed
P35869	P51532	SMARCA4	HPRD	PubMed
P35869	O00268	TAF4	HPRD	PubMed
P35869	Q15545	TAF7	HPRD	PubMed
P35869	P20226	TBP	HPRD	PubMed
P35869	O14980	XPO1	HPRD	PubMed
BioGRID:106699	BioGRID:114511	AIP	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:106699	BioGRID:106898	ARNT	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:106699	BioGRID:106899	ARNTL	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:106699	BioGRID:107343	CCNT1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:106699	BioGRID:107880	CTNNB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106699	BioGRID:113587	DAP3	BioGRID	PubMed	Reconstituted Complex
BioGRID:106699	BioGRID:108009	DDB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106699	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106699	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106699	BioGRID:109217	GTF2F1	BioGRID	PubMed	Reconstituted Complex
BioGRID:106699	BioGRID:109218	GTF2F2	BioGRID	PubMed	Reconstituted Complex
BioGRID:106699	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106699	BioGRID:115761	NCOA2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106699	BioGRID:110815	NEDD8	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106699	BioGRID:112883	NR2F1	BioGRID	PubMed	Reconstituted Complex
BioGRID:106699	BioGRID:113843	NRIP1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:106699	BioGRID:111860	RB1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:106699	BioGRID:111902	RELA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106699	BioGRID:112481	SMARCA4	BioGRID	PubMed	Reconstituted Complex
BioGRID:106699	BioGRID:112550	SP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:106699	BioGRID:112592	SRC	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:106699	BioGRID:115563	STUB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:106699	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106699	BioGRID:112771	TBP	BioGRID	PubMed	Reconstituted Complex
BioGRID:106699	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
DNA binding	TAS Traceable Author Statement more info	PubMed
Hsp90 protein binding	IDA Inferred from Direct Assay more info	PubMed
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein dimerization activity	TAS Traceable Author Statement more info	PubMed
protein heterodimerization activity	TAS Traceable Author Statement more info	PubMed
receptor activity	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity	IEA Inferred from Electronic Annotation more info
signal transducer activity	IEA Inferred from Electronic Annotation more info
transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
T cell homeostasis	IEA Inferred from Electronic Annotation more info
apoptotic process	TAS Traceable Author Statement more info	PubMed
blood vessel development	NAS Non-traceable Author Statement more info	PubMed
blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info
blood vessel remodeling	IEA Inferred from Electronic Annotation more info
camera-type eye development	IEA Inferred from Electronic Annotation more info
cell cycle	TAS Traceable Author Statement more info	PubMed
cell morphogenesis	IEA Inferred from Electronic Annotation more info
cellular response to glucocorticoid stimulus	IEA Inferred from Electronic Annotation more info
circumferential growth involved in left ventricle morphogenesis	IEA Inferred from Electronic Annotation more info
common bile duct development	IEA Inferred from Electronic Annotation more info
embryonic hemopoiesis	IEA Inferred from Electronic Annotation more info
glomerulus morphogenesis	IEA Inferred from Electronic Annotation more info
immune system process	IEA Inferred from Electronic Annotation more info
intracellular receptor mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
kidney morphogenesis	IEA Inferred from Electronic Annotation more info
liver development	IEA Inferred from Electronic Annotation more info
negative regulation of necrotic cell death	IEA Inferred from Electronic Annotation more info
negative regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
negative regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
negative regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
ovarian follicle development	IEA Inferred from Electronic Annotation more info
patterning of blood vessels	IEA Inferred from Electronic Annotation more info
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	IEA Inferred from Electronic Annotation more info
positive regulation of cell size	IEA Inferred from Electronic Annotation more info
positive regulation of growth rate	IEA Inferred from Electronic Annotation more info
positive regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
post-embryonic hemopoiesis	IEA Inferred from Electronic Annotation more info
prostate gland development	IEA Inferred from Electronic Annotation more info
regulation of B cell proliferation	IDA Inferred from Direct Assay more info	PubMed
regulation of blood vessel size	IEA Inferred from Electronic Annotation more info
regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	NAS Non-traceable Author Statement more info	PubMed
response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
response to stress	IDA Inferred from Direct Assay more info	PubMed
response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
smooth muscle tissue development	IEA Inferred from Electronic Annotation more info
spleen development	IEA Inferred from Electronic Annotation more info
transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
venous blood vessel development	IEA Inferred from Electronic Annotation more info
xenobiotic metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	IEA Inferred from Electronic Annotation more info
cytosolic aryl hydrocarbon receptor complex	TAS Traceable Author Statement more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
transcription factor complex	TAS Traceable Author Statement more info	PubMed

General protein information

Preferred Names: aryl hydrocarbon receptor

Names: aryl hydrocarbon receptor; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001621.4 → NP_001612.1 aryl hydrocarbon receptor precursor

Status: VALIDATED

Source sequence(s)

AA329775, AC003075, AK307495, BX505160, D16354, L19872

Consensus CDS

CCDS5366.1

UniProtKB/Swiss-Prot

P35869

Related

ENSP00000242057, OTTHUMP00000195583, ENST00000242057, OTTHUMT00000314620

Conserved Domains (3) summary

cd00130
Location:122 – 224
Blast Score: 138

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam00989
Location:113 – 226
Blast Score: 171

PAS; PAS fold

pfam08447
Location:297 – 382
Blast Score: 149

PAS_3; PAS fold

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p5 Primary Assembly

Range

17338276..17385775

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

17224763..17272268

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

17391672..17439185

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC003075.2 (113159..114659)	None
genomic	CH236948.1	EAL24281.1
genomic	CH471073.1	EAW93686.1
		EAW93687.1
genomic	D31708.1	None
genomic	D38044.1	BAA07235.1
genomic	U28063.1	AAA92082.1
genomic	U28064.1	AAA92083.1
genomic	U28066.1	AAA92084.1
mRNA	AA329775.1	None
mRNA	AK307495.1	None
mRNA	BC021696.1	None
mRNA	BC069390.1	AAH69390.1
mRNA	BC070080.1	AAH70080.1
mRNA	BQ020427.1	None
mRNA	BQ024331.1	None
mRNA	BX505160.1	None
mRNA	D16354.1	BAA03857.1
mRNA	L19872.1	AAA16210.1