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Abcd3 ATP-binding cassette, sub-family D (ALD), member 3 [ Mus musculus (house mouse) ]

Gene ID: 19299, updated on 28-May-2016
Official Symbol
Abcd3provided by MGI
Official Full Name
ATP-binding cassette, sub-family D (ALD), member 3provided by MGI
Primary source
MGI:MGI:1349216
See related
Ensembl:ENSMUSG00000028127 Vega:OTTMUSG00000031086
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PMP68; PMP70; Pxmp1; AI313901; AU018866; AW146054
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. [provided by RefSeq, Jul 2008]
Orthologs
Location:
3 52.94 cM; 3 G-H1
Exon count:
24
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (121758907..121815215, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (121461828..121518133, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930432M17 gene Neighboring gene predicted gene, 40136 Neighboring gene coagulation factor III Neighboring gene predicted gene, 33924 Neighboring gene predicted gene, 33987

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • ABC transporters, organism-specific biosystem (from KEGG)
    ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC transporters, conserved biosystem (from KEGG)
    ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC transporters in lipid homeostasis, organism-specific biosystem (from REACTOME)
    ABC transporters in lipid homeostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • ABC-family proteins mediated transport, organism-specific biosystem (from REACTOME)
    ABC-family proteins mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem (from WikiPathways)
    Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystemNuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. Ho...
  • Peroxisome, organism-specific biosystem (from KEGG)
    Peroxisome, organism-specific biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Peroxisome, conserved biosystem (from KEGG)
    Peroxisome, conserved biosystemPeroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding ISO
Inferred from Sequence Orthology
more info
 
ATPase activity ISO
Inferred from Sequence Orthology
more info
 
ATPase activity, coupled to transmembrane movement of substances IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acid transporter activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein self-association ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
peroxisomal long-chain fatty acid import IEA
Inferred from Electronic Annotation
more info
 
peroxisome organization ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
very long-chain fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
 
peroxisomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
ATP-binding cassette sub-family D member 3
Names
68 kDa peroxisomal membrane protein
70 kDa peroxisomal membrane protein
peroxisomal membrane protein 1
peroxisomal membrane protein, 70 kDa

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008991.2NP_033017.2  ATP-binding cassette sub-family D member 3

    See identical proteins and their annotated locations for NP_033017.2

    Status: REVIEWED

    Source sequence(s)
    AK004660, BY123916, CB245413
    Consensus CDS
    CCDS17806.1
    UniProtKB/Swiss-Prot
    P55096
    UniProtKB/TrEMBL
    Q9DBZ6
    Related
    ENSMUSP00000029770, OTTMUSP00000040614, ENSMUST00000029770, OTTMUST00000077011
    Conserved Domains (3) summary
    cd03223
    Location:440645
    ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
    pfam06472
    Location:59338
    ABC_membrane_2; ABC transporter transmembrane region 2
    TIGR00954
    Location:1647
    3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

    Range
    121758907..121815215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501152.1XP_006501215.1  

    Conserved Domains (3) summary
    cd03223
    Location:367572
    ABCD_peroxisomal_ALDP; ATP-binding cassette domain of peroxisomal transporter, subfamily D
    COG1132
    Location:4559
    MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
    pfam06472
    Location:1265
    ABC_membrane_2; ABC transporter transmembrane region 2

Alternate Mm_Celera

Genomic

  1. AC_000025.1 Alternate Mm_Celera

    Range
    128155294..128218276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)