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    EIF2C4 eukaryotic translation initiation factor 2C, 4 [ Homo sapiens ]

    Gene ID: 192670, updated on 12-May-2012
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    Summary

    Official Symbol
    EIF2C4provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 2C, 4provided by HGNC
    Primary source
    HGNC:18424
    See related
    Ensembl:ENSG00000134698; HPRD:09559; MIM:607356; Vega:OTTHUMG00000004243
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AGO4
    Summary
    This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1p34
    Sequence :
    Chromosome: 1; NC_000001.10 (36273828..36323491)
    See EIF2C4 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 216 Neighboring gene claspin Neighboring gene KIAA1430 pseudogene Neighboring gene eukaryotic translation initiation factor 2C, 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Argonaute proteins: potential biomarkers for human colon cancer. Li L, et al. BMC Cancer, 2010 Feb 10. PMID 20146808.
    3. Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells. Potenza N, et al. Cell Biol Int, 2009 Jul. PMID 19393748.
    4. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. Weinmann L, et al. Cell, 2009 Feb 6. PMID 19167051.
    5. Importance of translation and nonnucleolytic ago proteins for on-target RNA interference. Wu L, et al. Curr Biol, 2008 Sep 9. PMID 18771919.

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. EIF2C2-4 and PIWIL4 appear increased in advanced tumors with distant metastasis, suggesting they may promote tumor invasion
      Title: Argonaute proteins: potential biomarkers for human colon cancer.
    2. EIF2C4 protein is expressed in differentiating and terminally differentiated N-type cells more than in S- and I-type cells
      Title: Differential expression of Dicer and Argonaute genes during the differentiation of human neuroblastoma cells.
    3. The specificity of RNA interference depends on the concentration of Ago1, Ago3, and Ago4 relative to Ago2.
      Title: Importance of translation and nonnucleolytic ago proteins for on-target RNA interference.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:128178 BioGRID:106575 ACTB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:120868 AGK    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:106873 ARF4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:106997 ATP5C1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:107005 ATP5I    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:116603 CCT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:107997 DBT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:116978 DICER1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:128178 BioGRID:109534 DNAJA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:115582 DNAJA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:119699 DNAJB11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:108257 EEF1G    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:118041 EIF2C2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:128177 EIF2C3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:128178 EIF2C4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:108291 EIF4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:108325 EMD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:108857 GALK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:409828 HIN1L    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:109424 HNRNPC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:109558 HSP90AB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:109535 HSPA1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:109541 HSPA5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:109544 HSPA8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:115886 IGF2BP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:115781 IPO8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:128178 BioGRID:109919 JAK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:133742 LOC390937    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:117673 MYCBP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:114296 PABPC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:128154 PGAM5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:111089 PRDX1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:115688 PRMT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:115952 PTGES3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:111769 PTS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:112055 RPL11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:610124 RPL12P1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:114752 RPL23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:112071 RPL24    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:112074 RPL27    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:112076 RPL27A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:116392 RPL35    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:112088 RPL38    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:125006 RPS10P5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:112136 RPS18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:112145 RPS26    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:112107 RPS5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:112117 RPS9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:112464 SLC25A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:107850 SLC25A10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:115467 SLC25A13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:122862 SLC25A22    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:111269 SLC25A3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:106789 SLC25A5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:125635 SNRPD2P1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:112620 SSBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:114331 SUCLA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:118141 TNRC6A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:116735 TNRC6B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:112615 TRIM21    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:128444 TUBB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:115656 TUBB4B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:113135 TUFM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:122532 WDR77    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:128178 BioGRID:110959 YBX1    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • MicroRNA (miRNA) Biogenesis, organism-specific biosystem (from REACTOME)
      MicroRNA (miRNA) Biogenesis, organism-specific biosystemBiogenesis of microRNAs (miRNAs) can be summarized in five steps (reviewed in Ketting 2011, Nowotny and Yang 2009, Kim et al. 2009, Chua et al. 2009, Hannon and He 2004):1. Transcription. miRNA trans...
    • Post-transcriptional Silencing By Small RNAs, organism-specific biosystem (from REACTOME)
      Post-transcriptional Silencing By Small RNAs, organism-specific biosystemSmall RNAs act with components of the RNA-induced silencing complex (RISC) to repress expression of mRNAs (reviewed in Nowotny and Yang 2009, Chua et al. 2009). Two mechanisms exist: 1) cleavage of t...
    • Pre-NOTCH Expression and Processing, organism-specific biosystem (from REACTOME)
      Pre-NOTCH Expression and Processing, organism-specific biosystemIn humans and other mammals the NOTCH gene family has four members, NOTCH1, NOTCH2, NOTCH3 and NOTCH4, encoded on four different chromosomes. Their transcription is developmentally regulated and tiss...
    • Pre-NOTCH Transcription and Translation, organism-specific biosystem (from REACTOME)
      Pre-NOTCH Transcription and Translation, organism-specific biosystemIn humans, the NOTCH protein family has four members: NOTCH1, NOTCH2, NOTCH3 and NOTCH4. NOTCH1 protein was identified first, as the product of a chromosome 9 gene translocated in T-cell acute lympho...
    • Regulatory RNA pathways, organism-specific biosystem (from REACTOME)
      Regulatory RNA pathways, organism-specific biosystemIn this module, the biology of various types of regulatory non-coding RNAs are described. Currently, biogenesis and functions of small interfering RNAs (siRNAs) and microRNAs are annotated.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Small Interfering RNA (siRNA) Biogenesis, organism-specific biosystem (from REACTOME)
      Small Interfering RNA (siRNA) Biogenesis, organism-specific biosystemSmall interfering RNAs (siRNAs) are 21-25 nucleotide single-stranded RNAs produced by cleavage of longer double-stranded RNAs by the enzyme Dicer. Typically the long double-stranded substrates origin...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of translation involved in gene silencing by miRNA IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic mRNA processing body IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    protein argonaute-4
    Names
    protein argonaute-4
    hAgo4
    eIF2C 4
    eIF-2C 4
    argonaute4
    argonaute 4
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017629.3 → NP_060099.2  protein argonaute-4

      Status: REVIEWED

      Source sequence(s)
      AB046787, AL359186, CA419947
      Consensus CDS
      CCDS397.1
      UniProtKB/TrEMBL
      A7MD27
      UniProtKB/Swiss-Prot
      Q9HCK5
      Related
      ENSP00000362306, OTTHUMP00000004431, ENST00000373210, OTTHUMT00000012213
      Conserved Domains (4) summary
      cd02846
      Location:217 – 337
      Blast Score: 350
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:384 – 819
      Blast Score: 1494
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      PLN03202
      Location:15 – 860
      Blast Score: 1208
      PLN03202; protein argonaute; Provisional
      pfam08699
      Location:165 – 217
      Blast Score: 213
      DUF1785; Domain of unknown function (DUF1785)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      36273828..36323491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      34391417..34441140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL354864.16 CAH73806.1
    genomic AL359186.15 CAH71584.1
    genomic CH471059.2 EAX07398.1
      EAX07399.1
      EAX07400.1
    mRNA AB046787.1 BAB13393.1
    mRNA AK000040.1 BAA90899.1
    mRNA AL831908.1 None
    mRNA BC152450.1 AAI52451.1
    mRNA BG186585.1 None
    mRNA CA419947.1 None
    other-genetic BC160021.1 AAI60021.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HCK5.2 GenPept UniProtKB/Swiss-Prot:Q9HCK5
    Q9NXV9 GenPept UniProtKB/TrEMBL:Q9NXV9
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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