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Ptprc protein tyrosine phosphatase, receptor type, C [ Mus musculus (house mouse) ]

Gene ID: 19264, updated on 24-May-2016
Official Symbol
Ptprcprovided by MGI
Official Full Name
protein tyrosine phosphatase, receptor type, Cprovided by MGI
Primary source
MGI:MGI:97810
See related
Ensembl:ENSMUSG00000026395 Vega:OTTMUSG00000043098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
loc; B220; Cd45; L-CA; Ly-5; T200; CD45R; Lyt-4
Orthologs
Location:
1 E4; 1 60.73 cM
Exon count:
34
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (138062859..138175755, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (139959438..140071882, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene microRNA 181b-1 Neighboring gene predicted gene, 34353 Neighboring gene PAP associated domain containing 4 pseudogene Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit G3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ???? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation...
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • EPO Receptor Signaling, organism-specific biosystem (from WikiPathways)
    EPO Receptor Signaling, organism-specific biosystemThe erythropoietin receptor is a 66 kDa peptide and is a member of the cytokine receptor family. The receptor is tyrosine phosphorylated upon binding by erythropoietin and associates with and activat...
  • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Primary immunodeficiency, organism-specific biosystem (from KEGG)
    Primary immunodeficiency, organism-specific biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
  • Primary immunodeficiency, conserved biosystem (from KEGG)
    Primary immunodeficiency, conserved biosystemPrimary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells ...
  • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    T Cell Receptor Signaling Pathway, organism-specific biosystem
    T Cell Receptor Signaling Pathway
  • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • T cell receptor signaling pathway, conserved biosystem (from KEGG)
    T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
heparan sulfate proteoglycan binding IDA
Inferred from Direct Assay
more info
PubMed 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone marrow development ISO
Inferred from Sequence Orthology
more info
 
cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
 
heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
immunoglobulin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell adhesion involved in substrate-bound cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of alpha-beta T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of antigen receptor-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gamma-delta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of hematopoietic stem cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of humoral immune response mediated by circulating immunoglobulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of isotype switching to IgG isotypes IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive thymic T cell selection IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of humoral immune response mediated by circulating immunoglobulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
stem cell development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
receptor-type tyrosine-protein phosphatase C
Names
leukocyte common antigen
lymphocyte antigen 5
lymphocyte common antigen
NP_001104786.2
NP_001255215.1
NP_035340.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111316.2NP_001104786.2  receptor-type tyrosine-protein phosphatase C isoform 1 precursor

    See identical proteins and their annotated locations for NP_001104786.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC122903, AC159278, AK054056, BM239381, CA575153, CA577897, CK392851
    Consensus CDS
    CCDS48383.2
    UniProtKB/TrEMBL
    Q8C6Q7, S4R1S4
    Conserved Domains (5) summary
    pfam12453
    Location:731
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:211270
    CD45; Leukocyte receptor CD45
    smart00194
    Location:641900
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:669900
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:474553
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. NM_001268286.1NP_001255215.1  receptor-type tyrosine-protein phosphatase C precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks four in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC122903, AK054056, BM239381, CA575153, CA577897
    Consensus CDS
    CCDS59542.1
    UniProtKB/TrEMBL
    Q8C6Q7, S4R1M0
    Related
    ENSMUSP00000138275, OTTMUSP00000063322, ENSMUST00000182755, OTTMUST00000113096
    Conserved Domains (5) summary
    pfam12453
    Location:731
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:48107
    CD45; Leukocyte receptor CD45
    smart00194
    Location:478737
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:506737
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:311390
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. NM_011210.4NP_035340.3  receptor-type tyrosine-protein phosphatase C isoform 2 precursor

    See identical proteins and their annotated locations for NP_035340.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC122903, AK054056, BM239381, CA575153, CA577897
    Consensus CDS
    CCDS15330.2
    UniProtKB/TrEMBL
    Q8C6Q7, S4R2V1
    Related
    ENSMUSP00000138800, OTTMUSP00000063321, ENSMUST00000182283, OTTMUST00000113095
    Conserved Domains (5) summary
    pfam12453
    Location:731
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:72131
    CD45; Leukocyte receptor CD45
    smart00194
    Location:502761
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:530761
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:335414
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    138062859..138175755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529258.2XP_006529321.1  

    See identical proteins and their annotated locations for XP_006529321.1

    UniProtKB/TrEMBL
    S4R1S4
    Conserved Domains (5) summary
    pfam12453
    Location:731
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:211270
    CD45; Leukocyte receptor CD45
    smart00194
    Location:641900
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:669900
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:474553
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  2. XM_006529259.2XP_006529322.1  

    See identical proteins and their annotated locations for XP_006529322.1

    UniProtKB/TrEMBL
    S4R1S4
    Conserved Domains (5) summary
    pfam12453
    Location:731
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:211270
    CD45; Leukocyte receptor CD45
    smart00194
    Location:641900
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:669900
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:474553
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  3. XM_006529261.2XP_006529324.1  

    Conserved Domains (5) summary
    pfam12453
    Location:731
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:164223
    CD45; Leukocyte receptor CD45
    smart00194
    Location:594853
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:622853
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:427506
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  4. XM_006529262.2XP_006529325.1  

    Conserved Domains (5) summary
    pfam12453
    Location:731
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:121180
    CD45; Leukocyte receptor CD45
    smart00194
    Location:551810
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:579810
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:384463
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  5. XM_006529260.1XP_006529323.1  

    Conserved Domains (5) summary
    pfam12453
    Location:731
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:168227
    CD45; Leukocyte receptor CD45
    smart00194
    Location:598857
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:626857
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:431510
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
  6. XM_006529257.1XP_006529320.1  

    See identical proteins and their annotated locations for XP_006529320.1

    UniProtKB/TrEMBL
    S4R1S4
    Related
    ENSMUSP00000138350, OTTMUSP00000063320, ENSMUST00000183301, OTTMUST00000113094
    Conserved Domains (5) summary
    pfam12453
    Location:731
    PTP_N; Protein tyrosine phosphatase N terminal
    pfam12567
    Location:211270
    CD45; Leukocyte receptor CD45
    smart00194
    Location:641900
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:669900
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:474553
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    140702478..140816534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)