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    CG4747 [ Drosophila melanogaster ]

    Gene ID: 192507, updated on 4-Feb-2012
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    Summary

    Official Symbol
    CG4747provided by Flybase
    Primary source
    FLYBASE:FBgn0043456
    Locus tag
    Dmel_CG4747
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:GH19401; BEST:LD22483; BEST:LD29743; Dmel\CG4747; Dm_AI388468; LD29743
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    Genomic context

    Location :
    30F5-30F5
    Sequence :
    Chromosome: 2L; NT_033779.4 (10003825..10008889)
    See CG4747 in Epigenomics, MapViewer

    Chromosome 2L - NT_033779.4Genomic Context describing neighboring genes Neighboring gene CG13130 gene product from transcript CG13130-RA Neighboring gene big brain Neighboring gene CG31875 gene product from transcript CG31875-RC Neighboring gene CG31755 gene product from transcript CG31755-RB Neighboring gene Translocation protein 1 Neighboring gene CG13131 gene product from transcript CG13131-RB

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Sequence finishing and mapping of Drosophila melanogaster heterochromatin. Hoskins RA, et al. Science, 2007 Jun 15. PMID 17569867.
    2. The Release 5.1 annotation of Drosophila melanogaster heterochromatin. Smith CD, et al. Science, 2007 Jun 15. PMID 17569856.
    3. p53 directs focused genomic responses in Drosophila. Akdemir F, et al. Oncogene, 2007 Aug 9. PMID 17310982.
    4. Combined evidence annotation of transposable elements in genome sequences. Quesneville H, et al. PLoS Comput Biol, 2005 Jul. PMID 16110336.
    5. A protein interaction map of Drosophila melanogaster. Giot L, et al. Science, 2003 Dec 5. PMID 14605208.

    See all (13) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:72969 BioGRID:66688 CG11656    BioGRID  PubMed Two-hybrid 
    BioGRID:72969 BioGRID:66873 CG14860    BioGRID  PubMed Two-hybrid 
    BioGRID:72969 BioGRID:60642 CG14932    BioGRID  PubMed Two-hybrid 
    BioGRID:72969 BioGRID:58346 CG3099    BioGRID  PubMed Two-hybrid 
    BioGRID:72969 BioGRID:58292 CG6999    BioGRID  PubMed Two-hybrid 
    BioGRID:72969 BioGRID:64238 Neos    BioGRID  PubMed Two-hybrid 
    BioGRID:72969 BioGRID:60561 UbcD2    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the CG4747 gene: The CG4747 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, mosquito, A.thaliana, and rice.

    Pathways from BioSystems

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    3-hydroxyisobutyrate dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    coenzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphogluconate dehydrogenase (decarboxylating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    pentose-phosphate shunt IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
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    General protein information

    Preferred Names
    CG4747 gene product from transcript CG4747-RB
    Names
    CG4747
    CG4747-PA
    CG4747-PB
    NP_001188767.1
    NP_609336.3
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.4

      Range
      10003825..10008889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201838.1 → NP_001188767.1  CG4747, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      Conserved Domains (4) summary
      COG2084
      Location:319 – 598
      Blast Score: 543
      MmsB; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]
      cd05836
      Location:20 – 106
      Blast Score: 394
      N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
      PRK00708
      Location:176 – 267
      Blast Score: 89
      PRK00708; sec-independent translocase; Provisional
      cl09931
      Location:317 – 389
      Blast Score: 112
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_135492.4 → NP_609336.3  CG4747, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T079
      Related
      FBpp0079520
      Conserved Domains (4) summary
      COG2084
      Location:319 – 597
      Blast Score: 550
      MmsB; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]
      cd05836
      Location:20 – 106
      Blast Score: 394
      N_Pac_NP60; The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the ...
      PRK00708
      Location:176 – 267
      Blast Score: 89
      PRK00708; sec-independent translocase; Provisional
      cl09931
      Location:317 – 389
      Blast Score: 112
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014134.5 ADV37017.1
    genomic AE014134.5 AAF52846.3
    mRNA AY069497.1 AAL39642.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    AAF52846.2 GenPept
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

      Supplemental Content