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Ptn pleiotrophin [ Mus musculus (house mouse) ]

Gene ID: 19242, updated on 28-May-2016
Official Symbol
Ptnprovided by MGI
Official Full Name
pleiotrophinprovided by MGI
Primary source
MGI:MGI:97804
See related
Ensembl:ENSMUSG00000029838
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OSF; HARP; HBBN; HBNF; Osf1; Osf-1; HB-GAM; HBGF-8
Orthologs
Location:
6 B1; 6 15.48 cM
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (36714909..36811361, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (36665663..36761361, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene cholinergic receptor, muscarinic 2, cardiac Neighboring gene microRNA 490 Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene diacylglycerol kinase, iota Neighboring gene predicted pseudogene 7452 Neighboring gene cAMP responsive element binding protein 3-like 2 Neighboring gene predicted gene, 33275

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chondroitin sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
glycosaminoglycan binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
heparan sulfate binding ISO
Inferred from Sequence Orthology
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
vascular endothelial growth factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
bone mineralization IDA
Inferred from Direct Assay
more info
PubMed 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
negative regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
 
ossification IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hepatocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of skeletal muscle acetylcholine-gated channel clustering ISO
Inferred from Sequence Orthology
more info
 
regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
retinal rod cell differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
basement membrane ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
extracellular region ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
proteinaceous extracellular matrix TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
pleiotrophin
Names
HBBM
heparin affin regulatory peptide
heparin-binding brain mitogen
heparin-binding growth factor 8
heparin-binding growth-associated molecule
heparin-binding neurite promoting factor
heparin-binding neurotorphic factor
heparin-binding neutrophic factor
osteoblast-specific factor 1
osteoblastic cell factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008973.2NP_032999.1  pleiotrophin precursor

    See identical proteins and their annotated locations for NP_032999.1

    Status: PROVISIONAL

    Source sequence(s)
    AC153902, AC154019
    Consensus CDS
    CCDS20005.1
    UniProtKB/Swiss-Prot
    P63089
    Related
    ENSMUSP00000099073, OTTMUSP00000072973, ENSMUST00000101534, OTTMUST00000138926
    Conserved Domains (1) summary
    cl02505
    Location:47131
    PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    36714909..36811361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505757.2XP_006505820.2  

    See identical proteins and their annotated locations for XP_006505820.2

    UniProtKB/Swiss-Prot
    P63089
    Conserved Domains (1) summary
    cl02505
    Location:47131
    PTN_MK_N; PTN/MK heparin-binding protein family, N-terminal domain

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    36692206..36788072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)