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tsp-15 Tetraspanin-15 [ Caenorhabditis elegans ]

Gene ID: 192065, updated on 23-Nov-2023

Summary

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Gene symbol
tsp-15
Gene description
Tetraspanin-15
Primary source
WormBase:WBGene00006641
Locus tag
CELE_F53B6.1
See related
AllianceGenome:WB:WBGene00006641
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in cuticle development involved in collagen and cuticulin-based cuticle molting cycle and skin epidermis development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in body wall musculature; hyp7 syncytium; pharynx; seam cell; and vulva. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: I
Exon count:
6
Sequence:
Chromosome: I; NC_003279.8 (8928750..8931089)

Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene SH2 domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Protein madd-4 Neighboring gene Fungus-Induced Protein Neighboring gene FIP (Fungus-Induced Protein) Related

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of intragenic suppressor of tsp-15-splicing mutant in Caenorhabditis elegans. Moribe H, et al. MicroPubl Biol, 2019 Jul 23. PMID 32550409, Free PMC Article
  2. Co-occurrence of tetraspanin and ROS generators: Conservation in protein cross-linking and other developmental processes. Moribe H, et al. Worm, 2013 Apr 1. PMID 24058871, Free PMC Article
  3. The BLI-3/TSP-15/DOXA-1 dual oxidase complex is required for iodide toxicity in Caenorhabditis elegans. Xu Z, et al. G3 (Bethesda), 2014 Dec 4. PMID 25480962, Free PMC Article
  4. Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans. Moribe H, et al. PLoS Genet, 2012 Sep. PMID 23028364, Free PMC Article
  5. Tetraspanin protein (TSP-15) is required for epidermal integrity in Caenorhabditis elegans. Moribe H, et al. J Cell Sci, 2004 Oct 15. PMID 15454573

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BLI-3/TSP-15/DOXA-1 dual oxidase complex is required for the toxic pleiotropic effects of excess iodide.
    Title: The BLI-3/TSP-15/DOXA-1 dual oxidase complex is required for iodide toxicity in Caenorhabditis elegans.
  2. We demonstrated that TSP-15, BLI-3, and DOXA-1 form complexes in vitro and in vivo. Cell-fusion-based analysis suggested that association with TSP-15 at the cell surface is crucial for BLI-3 activation to release H(2)O(2).
    Title: Tetraspanin is required for generation of reactive oxygen species by the dual oxidase system in Caenorhabditis elegans.
  3. TSP-15 functions in the maintenance of epithelial cell integrity
    Title: Tetraspanin protein (TSP-15) is required for epidermal integrity in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cuticle development involved in collagen and cuticulin-based cuticle molting cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skin epidermis development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Tetraspanin-15
NP_492404.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003279.8 Reference assembly

    Range
    8928750..8931089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_060003.7 → NP_492404.1  Tetraspanin-15 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_492404.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XVM9
    Conserved Domains (2) summary
    cd03156
    Location:110 → 228
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:16 → 256
    Tetraspannin; Tetraspanin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XVM9.2

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