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Psme2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) [ Mus musculus (house mouse) ]

Gene ID: 19188, updated on 8-May-2016
Official Symbol
Psme2provided by MGI
Official Full Name
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)provided by MGI
Primary source
MGI:MGI:1096365
See related
Ensembl:ENSMUSG00000079197 Vega:OTTMUSG00000034667
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PA28b; AA589371; AI788882
Orthologs
Location:
14 28.19 cM; 14 C2-D1
Exon count:
12
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 14 NC_000080.6 (55587440..55591146, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (56206277..56209938, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene fat storage-inducing transmembrane protein 1 Neighboring gene proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Neighboring gene ER membrane protein complex subunit 9 Neighboring gene ring finger protein 31 Neighboring gene interferon regulatory factor 9

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
endopeptidase activator activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
antigen processing and presentation of exogenous antigen IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
proteasome complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
proteasome activator complex subunit 2
Names
11S regulator complex subunit beta
PA28beta
REG-beta
activator of multicatalytic protease subunit 2
protease (prosome, macropain) 28 subunit, beta
proteasome (prosome, macropain) 28 subunit, beta
proteasome activator 28 subunit beta

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029855.1NP_001025026.1  proteasome activator complex subunit 2 isoform 2

    See identical proteins and their annotated locations for NP_001025026.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate transcription initiation site and uses a distinct start codon, compared to variant 1. The resulting protein (isoform 2) has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA216967, AA267668, AK012344, BB869062
    Consensus CDS
    CCDS49495.1
    UniProtKB/Swiss-Prot
    P97372
    UniProtKB/TrEMBL
    G3X9V0
    Related
    ENSMUSP00000107009, ENSMUST00000111378
    Conserved Domains (2) summary
    pfam02252
    Location:82231
    PA28_beta; Proteasome activator pa28 beta subunit
    pfam02251
    Location:959
    PA28_alpha; Proteasome activator pa28 alpha subunit
  2. NM_011190.3NP_035320.1  proteasome activator complex subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_035320.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA216967, AK012344, BU563130, BY134400, BY498670, CA536627
    Consensus CDS
    CCDS49494.1
    UniProtKB/Swiss-Prot
    P97372
    UniProtKB/TrEMBL
    Q5SVP3
    Related
    ENSMUSP00000123798, OTTMUSP00000047933, ENSMUST00000161807, OTTMUST00000087990
    Conserved Domains (2) summary
    pfam02252
    Location:90239
    PA28_beta; Proteasome activator pa28 beta subunit
    pfam02251
    Location:967
    PA28_alpha; Proteasome activator pa28 alpha subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p3 C57BL/6J

    Range
    55587440..55591146 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_383146.2 RNA Sequence

  2. XR_383145.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000036.1 Alternate Mm_Celera

    Range
    53392500..53396161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)