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nhr-38 Nuclear receptor domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 191720, updated on 11-Apr-2024

Summary

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Gene symbol
nhr-38
Gene description
Nuclear receptor domain-containing protein
Primary source
WormBase:WBGene00003629
Locus tag
CELE_K01H12.3
See related
AllianceGenome:WB:WBGene00003629
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in hormone-mediated signaling pathway; regulation of transcription by RNA polymerase II; and tissue development. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in AFDL and AFDR. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See nhr-38 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (9710187..9712420)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene DPH3 homolog;Diphthamide biosynthesis protein 3 Neighboring gene ADP/ATP translocase Neighboring gene Breast cancer type 2 susceptibility protein homolog Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The CMK-1 CaMKI and the TAX-4 Cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C. elegans. Satterlee JS, et al. Curr Biol, 2004 Jan 6. PMID 14711416
  2. Expression and function of members of a divergent nuclear receptor family in Caenorhabditis elegans. Miyabayashi T, et al. Dev Biol, 1999 Nov 15. PMID 10545240
  3. Distribution and movement of Caenorhabditis elegans on a thermal gradient. Yamada Y, et al. J Exp Biol, 2003 Aug. PMID 12819265
  4. Specification of thermosensory neuron fate in C. elegans requires ttx-1, a homolog of otd/Otx. Satterlee JS, et al. Neuron, 2001 Sep 27. PMID 11580895
  5. Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans. Lewis JA, et al. BMC Genomics, 2009 Apr 29. PMID 19402892, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear receptor domain-containing protein
NP_001293921.1
  • Confirmed by transcript evidence
NP_501728.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9710187..9712420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069327.3 → NP_501728.2  Nuclear receptor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501728.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21104
    Conserved Domains (1) summary
    smart00399
    Location:32 → 102
    ZnF_C4; c4 zinc finger in nuclear hormone receptors

  2. NM_001306992.3 → NP_001293921.1  Nuclear receptor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293921.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AKS3
Nucleotide Protein
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Gene LinkOut

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