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nex-3 Annexin [ Caenorhabditis elegans ]

Gene ID: 191716, updated on 11-Apr-2024

Summary

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Gene symbol
nex-3
Gene description
Annexin
Primary source
WormBase:WBGene00003590
Locus tag
CELE_C28A5.3
See related
AllianceGenome:WB:WBGene00003590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables heparan sulfate proteoglycan binding activity; heparin binding activity; and phospholipid binding activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See nex-3 in Genome Data Viewer
Location:
chromosome: III
Exon count:
6
Sequence:
Chromosome: III; NC_003281.10 (4442081..4444237)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Ig-like domain-containing protein Neighboring gene REJ domain-containing protein Neighboring gene Homeobox domain-containing protein;Homeobox protein ceh-43 Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene tRNA-Arg

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Prediction pipeline for discovery of regulatory motifs associated with Brugia malayi molting. Grote A, et al. PLoS Negl Trop Dis, 2020 Jun. PMID 32574217, Free PMC Article
  2. Ligand-binding activity and expression profile of annexins in Caenorhabditis elegans. Nishioka S, et al. J Biochem, 2007 Jan. PMID 17169974
  3. Transcription, biochemistry and localization of nematode annexins. Daigle SN, et al. J Cell Sci, 1999 Jun. PMID 10341209
  4. Identification, localization, and functional implications of an abundant nematode annexin. Creutz CE, et al. J Cell Biol, 1996 Mar. PMID 8601586, Free PMC Article
  5. Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD(+) in axon regeneration. Kim KW, et al. Elife, 2018 Nov 21. PMID 30461420, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
  
enables heparan sulfate proteoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparan sulfate proteoglycan binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylethanolamine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Annexin
NP_497903.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    4442081..4444237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_065502.4 → NP_497903.1  Annexin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_497903.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q27473
    Conserved Domains (1) summary
    pfam00191
    Location:87 → 151
    Annexin; Annexin
Nucleotide Protein
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