EEF1A2 eukaryotic translation elongation factor 1 alpha 2 [Homo sapiens] - Gene

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Summary

Official Symbol: EEF1A2provided by HGNC
Official Full Name: eukaryotic translation elongation factor 1 alpha 2provided by HGNC
Primary source: HGNC:3192
See related: Ensembl:ENSG00000101210; HPRD:04265; MIM:602959; Vega:OTTHUMG00000033076
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HS1; STN; EF1A; STNL; EEF1AL; EF-1-alpha-2
Summary: This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

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Genomic context

Location :: 20q13.3

Sequence :: Chromosome: 20; NC_000020.10 (62119366..62130505, complement)

See EEF1A2 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pilot evaluation in archive prostate tissues showed the presence of EEF1A2 mRNA in near all neoplastic and perineoplastic but not in normal samples or in benign adenoma; in contrast, EEF1A1 mRNA was everywhere detectable
Title: Dissecting the expression of EEF1A1/2 genes in human prostate cancer cells: the potential of EEF1A2 as a hallmark for prostate transformation and progression.
The eEF1A2 likely plays an important role in mammary neoplasia and acinar development.
Title: The lipid kinase PI4KIIIβ and the eEF1A2 oncogene co-operate to disrupt three-dimensional in vitro acinar morphogenesis.
Observational study of gene-disease association, gene-gene interaction, and genetic testing. (HuGE Navigator)
Title: A panel of sputum-based genomic marker for early detection of lung cancer.
Levels of eEF1A2 and alpha-actinin-4 mRNA appeared to be unrelated to breast tumour size, except for a significant down-regulation of alpha-actinin-4 mRNA in T3 cases.
Title: Expression of the actin-binding proteins indicates that cofilin and fascin are related to breast tumour size.
EEF1A2 may play contribute to the induction or progression of some plasmacytomas and a small percentage of multiple myeloma.
Title: Eef1a2 promotes cell growth, inhibits apoptosis and activates JAK/STAT and AKT signaling in mouse plasmacytomas.
this population-based study of individuals with incident AD, use of statins and beta-blockers was associated with delay of functional decline.
Title: Effects of cardiovascular medications on rate of functional decline in Alzheimer disease.
overall, this study does not support an associated between statin use and prostate cancer but a reduced risk cannot be ruled out.
Title: Statin use and prostate cancer risk in a large population-based setting.
the interaction of ZPR1 and eEF1alpha
Title: Generation of a zinc finger protein ZPR1 mutant that constitutively interacted with translation elongation factor 1alpha.
created and validated comparative three-dimensional (3-D) models of eEF1A1 and eEF1A2 on the basis of the crystal structure of homologous eEF1A from yeast
Title: Structural models of human eEF1A1 and eEF1A2 reveal two distinct surface clusters of sequence variation and potential differences in phosphorylation.
Studies indicate that the EEF1A2 abnormal expression in cancers correlates with a poor prognosis.
Title: eEF1A2 as a putative oncogene.

Submit: New GeneRIF Correction See all (22)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	EF-1alpha stimulates the binding of RNA Polymerase II and TRP-185 to HIV-1 TAR RNA, suggesting an interaction between EF-1alpha and HIV-1 Tat	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_001949.1	NP_000732.2	CHRM4	BIND	PubMed	The third intracellular loop of M4 interacts with eEf1A2.
Q05639	P08173	CHRM4	HPRD	PubMed
BioGRID:108238	BioGRID:108253	EEF1B2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108238	BioGRID:108256	EEF1D	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108238	BioGRID:109314	HTT	BioGRID	PubMed	Two-hybrid
BioGRID:108238	BioGRID:111583	MAPK6	BioGRID	PubMed	Two-hybrid
BioGRID:108238	BioGRID:110411	MGMT	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108238	BioGRID:110815	NEDD8	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108238	BioGRID:111700	PTEN	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108238	BioGRID:117071	SRRM2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108238	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:108238	BioGRID:113250	VARS	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
GTP binding	IEA Inferred from Electronic Annotation more info
GTPase activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
translation elongation factor activity	IEA Inferred from Electronic Annotation more info
translation factor activity, nucleic acid binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
anti-apoptosis	IEA Inferred from Electronic Annotation more info
response to inorganic substance	IEA Inferred from Electronic Annotation more info
translation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
eukaryotic translation elongation factor 1 complex	IEA Inferred from Electronic Annotation more info
neuronal cell body	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: elongation factor 1-alpha 2

Names: elongation factor 1-alpha 2; eEF1A-2; statin S1; statin-S1; elongation factor-1 alpha; eukaryotic elongation factor 1 A-2

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001958.2 → NP_001949.1 elongation factor 1-alpha 2

Status: REVIEWED

Source sequence(s)

AF163763, X70940

Consensus CDS

CCDS13522.1

UniProtKB/Swiss-Prot

Q05639

Related

ENSP00000217182, ENST00000217182

Conserved Domains (4) summary

cd03705
Location:336 – 438
Blast Score: 476

EF1_alpha_III; Domain III of EF-1. Eukaryotic elongation factor 1 (EF-1) is responsible for the GTP-dependent binding of aminoacyl-tRNAs to ribosomes. EF-1 is composed of four subunits: the alpha chain, which binds GTP and aminoacyl-tRNAs, the gamma chain that probably ...

cd03693
Location:242 – 332
Blast Score: 436

EF1_alpha_II; EF1_alpha_II: this family represents the domain II of elongation factor 1-alpha (EF-1a) that is found in archaea and all eukaryotic lineages. EF-1A is very abundant in the cytosol, where it is involved in the GTP-dependent binding of aminoacyl-tRNAs to ...

PTZ00141
Location:1 – 457
Blast Score: 2261

PTZ00141; elongation factor 1- alpha; Provisional

cd01883
Location:9 – 238
Blast Score: 1178

EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

62119366..62130505, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

58848704..58860722, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF163763.1	AAF80488.1
genomic	AL121829.30	CAC15522.1
genomic	CH471077.2	EAW75259.1
		EAW75260.1
mRNA	AB209064.1	BAD92301.1
mRNA	AB451389.1	BAG70203.1
mRNA	AK123690.1	None
mRNA	AK307536.1	None
mRNA	BC000432.2	AAH00432.1
mRNA	BC018855.2	None
mRNA	BC110409.1	AAI10410.1
mRNA	L10340.1	AAA91835.1
mRNA	X70940.1	CAA50280.1
other-genetic	DQ894570.2	ABM85496.1