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EEF1A2 eukaryotic translation elongation factor 1 alpha 2 [ Homo sapiens (human) ]

Gene ID: 1917, updated on 23-Jul-2015
Official Symbol
EEF1A2provided by HGNC
Official Full Name
eukaryotic translation elongation factor 1 alpha 2provided by HGNC
Primary source
HGNC:HGNC:3192
See related
Ensembl:ENSG00000101210; HPRD:04265; MIM:602959; Vega:OTTHUMG00000033076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HS1; STN; EF1A; STNL; MRD38; EEF1AL; EIEE33; EF-1-alpha-2
Summary
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. [provided by RefSeq, Mar 2014]
Orthologs
See EEF1A2 in Epigenomics, MapViewer
Location:
20q13.3
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (63488012..63499315, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (62119365..62130668, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene potassium channel, voltage gated KQT-like subfamily Q, member 2 Neighboring gene uncharacterized LOC105372721 Neighboring gene uncharacterized LOC105372720 Neighboring gene uncharacterized LOC105372725 Neighboring gene uncharacterized LOC102723814

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 33
MedGen: CN231149 OMIM: 616409 GeneReviews: Not available
not available
MENTAL RETARDATION, AUTOSOMAL DOMINANT 38
MedGen: CN231146 OMIM: 616393 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat EF-1alpha stimulates the binding of RNA Polymerase II and TRP-185 to HIV-1 TAR RNA, suggesting an interaction between EF-1alpha and HIV-1 Tat PubMed

Go to the HIV-1, Human Interaction Database

  • Eukaryotic Translation Elongation, organism-specific biosystem (from REACTOME)
    Eukaryotic Translation Elongation, organism-specific biosystemThe translation elongation cycle adds one amino acid at a time to a growing polypeptide according to the sequence of codons found in the mRNA. The next available codon on the mRNA is exposed in the a...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Legionellosis, organism-specific biosystem (from KEGG)
    Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Legionellosis, conserved biosystem (from KEGG)
    Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Translation, organism-specific biosystem (from REACTOME)
    Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
  • Translation Factors, organism-specific biosystem (from WikiPathways)
    Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ41696

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
translation factor activity, RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lipid kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
response to inorganic substance IEA
Inferred from Electronic Annotation
more info
 
translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
eukaryotic translation elongation factor 1 complex IEA
Inferred from Electronic Annotation
more info
 
myelin sheath IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
NOT nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
elongation factor 1-alpha 2
Names
eukaryotic elongation factor 1 A-2
statin-S1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034083.1 RefSeqGene

    Range
    5001..16302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001958.3NP_001949.1  elongation factor 1-alpha 2

    See identical proteins and their annotated locations for NP_001949.1

    Status: REVIEWED

    Source sequence(s)
    BC110409, BM476361, BQ944047
    Consensus CDS
    CCDS13522.1
    UniProtKB/Swiss-Prot
    Q05639
    Related
    ENSP00000217182, ENST00000217182
    Conserved Domains (4) summary
    PTZ00141
    Location:1460
    PTZ00141; elongation factor 1- alpha; Provisional
    cd01883
    Location:9238
    EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family
    cd03693
    Location:242332
    EF1_alpha_II; EF1_alpha_II: this family represents the domain II of elongation factor 1-alpha (EF-1a) that is found in archaea and all eukaryotic lineages. EF-1A is very abundant in the cytosol, where it is involved in the GTP-dependent binding of aminoacyl-tRNAs to ...
    cd03705
    Location:336438
    EF1_alpha_III; Domain III of EF-1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

    Range
    63488012..63499315
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    62020420..62031789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)