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Prkar1a protein kinase, cAMP dependent regulatory, type I, alpha [ Mus musculus (house mouse) ]

Gene ID: 19084, updated on 3-May-2016
Official Symbol
Prkar1aprovided by MGI
Official Full Name
protein kinase, cAMP dependent regulatory, type I, alphaprovided by MGI
Primary source
MGI:MGI:104878
See related
Ensembl:ENSMUSG00000020612 Vega:OTTMUSG00000003351
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tse1; Tse-1; RIalpha; 1300018C22Rik
Summary
The encoded protein is a regulatory subunit of the cAMP-dependent protein kinase (PKA) complex, which is responsible for transducing most of the cAMP signals in eukaryotic cells. The inactive PKA complex contains two regulatory and two catalytic subunits. Binding of cAMP dissociates the complex, allowing monomeric catalytic subunits to phosphorylate cytosolic proteins or induce gene expression in the nucleus. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2015]
Orthologs
Location:
11 E1; 11 72.33 cM
Exon count:
13
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (109649395..109669659)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (109512263..109530962)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene WD repeat domain, phosphoinositide interacting 1 Neighboring gene predicted gene, 39442 Neighboring gene predicted gene, 29875 Neighboring gene predicted gene, 39443 Neighboring gene family with sequence similarity 20, member A Neighboring gene uncharacterized LOC105243553 Neighboring gene predicted gene, 42093

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cAMP binding ISO
Inferred from Sequence Orthology
more info
 
cAMP-dependent protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
cAMP-dependent protein kinase regulator activity IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-dependent protein kinase regulator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
cAMP-dependent protein kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cAMP-dependent protein kinase regulator activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cAMP-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with immunological synapse ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide-activated protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane raft ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cAMP-dependent protein kinase type I-alpha regulatory subunit
Names
protein kinase, cAMP dependent regulatory, type 1, alpha
NP_068680.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313973.1NP_001300902.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All five variants encode the same protein.
    Source sequence(s)
    AK051068, BB610165, BP754173, BY309580
    UniProtKB/Swiss-Prot
    Q9DBC7
    Conserved Domains (3) summary
    cd12101
    Location:1463
    DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:249359
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  2. NM_001313974.1NP_001300903.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AK051068, BP754173, BY129491
    UniProtKB/Swiss-Prot
    Q9DBC7
    Conserved Domains (3) summary
    cd12101
    Location:1463
    DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:249359
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  3. NM_001313975.1NP_001300904.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AK051068, BB850806, BP754173, CX243222
    UniProtKB/Swiss-Prot
    Q9DBC7
    Conserved Domains (3) summary
    cd12101
    Location:1463
    DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:249359
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  4. NM_001313976.1NP_001300905.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AK051068, BB850806, BP754173, CF727817
    UniProtKB/Swiss-Prot
    Q9DBC7
    Conserved Domains (3) summary
    cd12101
    Location:1463
    DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:249359
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  5. NM_021880.3NP_068680.1  cAMP-dependent protein kinase type I-alpha regulatory subunit

    See identical proteins and their annotated locations for NP_068680.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All five variants encode the same protein.
    Source sequence(s)
    AK051068, BP754173, BY034044
    Consensus CDS
    CCDS25583.1
    UniProtKB/Swiss-Prot
    Q9DBC7
    Related
    ENSMUSP00000056500, OTTMUSP00000003353, ENSMUST00000049527, OTTMUST00000007043
    Conserved Domains (3) summary
    cd12101
    Location:1463
    DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:249359
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    109649395..109669659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248801.1XP_011247103.1  

    Conserved Domains (3) summary
    cd12101
    Location:1463
    DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:249359
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  2. XM_006532511.1XP_006532574.1  

    Related
    ENSMUSP00000102288, OTTMUSP00000003354, ENSMUST00000106677, OTTMUST00000007044
    Conserved Domains (3) summary
    cd12101
    Location:1463
    DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:249359
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:255370
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  3. XM_006532509.1XP_006532572.1  

    See identical proteins and their annotated locations for XP_006532572.1

    UniProtKB/TrEMBL
    Q3TYK4
    Conserved Domains (4) summary
    cd12101
    Location:143192
    DD_RIalpha_PKA; Dimerization/Docking domain of the Type I alpha Regulatory subunit of cAMP-dependent protein kinase
    COG0664
    Location:378488
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:384499
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd13394
    Location:89171
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    121389458..121408159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)