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Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [ Mus musculus (house mouse) ]

Gene ID: 19017, updated on 3-Mar-2015
Official Symbol
Ppargc1aprovided by MGI
Official Full Name
peroxisome proliferative activated receptor, gamma, coactivator 1 alphaprovided by MGI
Primary source
MGI:MGI:1342774
See related
Ensembl:ENSMUSG00000029167; Vega:OTTMUSG00000022759
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pgc1; PGC-1; Pgco1; PGC-1v; Gm11133; Ppargc1; Pgc-1alpha; A830037N07Rik; ENSMUSG00000079510
Orthologs
See Ppargc1a in MapViewer
Location:
5; 5 C1
Exon count:
18
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (51454249..52115958, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene predicted gene, 29924 Neighboring gene uncharacterized LOC105244746 Neighboring gene microRNA 6417 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 15

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II transcription cofactor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
ligand-dependent nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
ligand-dependent nuclear receptor transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ligand-dependent nuclear receptor transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion organization ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of receptor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ATP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cellular metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular respiration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fatty acid oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitochondrial DNA metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of N-methyl-D-aspartate selective glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
respiratory electron transport chain IDA
Inferred from Direct Assay
more info
PubMed 
response to dietary excess IDA
Inferred from Direct Assay
more info
PubMed 
response to muscle activity IDA
Inferred from Direct Assay
more info
PubMed 
response to muscle activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
transcription from RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Names
peroxisome proliferator-activated receptor gamma coactivator 1-alpha
PGC-1-alpha
PPAR Gamma Coactivator-1
PPAR gamma coactivator variant form
PPAR-gamma coactivator 1-alpha
PPARGC-1-alpha
Pgc-1alphaa
peroxisome proliferator-activated receptor gamma coactivator-1 alpha

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008904.2NP_032930.1  peroxisome proliferator-activated receptor gamma coactivator 1-alpha

    See proteins identical to NP_032930.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a functional protein.
    Source sequence(s)
    AC116763, AK138668
    Consensus CDS
    CCDS19282.1
    UniProtKB/Swiss-Prot
    O70343
    Related
    ENSMUSP00000117040, OTTMUSP00000026095, ENSMUST00000132734, OTTMUST00000054635
    Conserved Domains (1) summary
    cd12623
    Location:674764
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins

RNA

  1. NR_027710.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional segment in the coding region, compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a protein.
    Source sequence(s)
    AB061324, AC116763, AK138668

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    51454249..52115958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503774.2XP_006503837.1  

    Conserved Domains (1) summary
    cd12623
    Location:687777
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
  2. XM_006503776.2XP_006503839.1  

    Conserved Domains (1) summary
    cd12623
    Location:664754
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
  3. XM_006503775.1XP_006503838.1  

    Conserved Domains (1) summary
    cd12623
    Location:670760
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
  4. XM_006503777.2XP_006503840.1  

    Conserved Domains (1) summary
    cd12623
    Location:661751
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
  5. XM_006503778.2XP_006503841.1  

    Conserved Domains (1) summary
    cd12623
    Location:659749
    RRM_PPARGC1A; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha, or PPARGC-1-alpha) and similar proteins
  6. XM_006503779.2XP_006503842.1  

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    48830811..48929055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)