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Pou5f1 POU domain, class 5, transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 18999, updated on 23-Apr-2014
Official Symbol
Pou5f1provided by MGI
Official Full Name
POU domain, class 5, transcription factor 1provided by MGI
Primary source
MGI:101893
See related
Ensembl:ENSMUSG00000024406; Vega:OTTMUSG00000037235
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oct3; Oct4; Otf3; Otf4; NF-A3; Oct-3; Oct-4; Otf-3; Otf-4; Otf3g; Oct3/4; Oct-3/4; Otf3-rs7
Location :
17 B1; 17 18.69 cM
Sequence :
Chromosome: 17; NC_000083.6 (35506032..35510777)
See Pou5f1 in Epigenomics, MapViewer

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene histocompatibility 2, Q region locus 10 Neighboring gene uncharacterized LOC102634885 Neighboring gene predicted gene, 19553 Neighboring gene transcription factor 19 Neighboring gene coiled-coil alpha-helical rod protein 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
HMG box domain binding ISO
Inferred from Sequence Orthology
more info
 
POU domain binding ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
miRNA binding ISO
Inferred from Sequence Orthology
more info
 
poly(A) RNA binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding RNA polymerase II transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
BMP signaling pathway involved in heart induction ISO
Inferred from Sequence Orthology
more info
 
cardiac cell fate determination ISO
Inferred from Sequence Orthology
more info
 
cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate commitment involved in formation of primary germ layer ISO
Inferred from Sequence Orthology
more info
 
ectodermal cell fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
endodermal cell fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
endodermal cell fate specification ISO
Inferred from Sequence Orthology
more info
 
germ-line stem cell maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
mesodermal cell fate commitment IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of calcium ion-dependent exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of gene silencing by miRNA ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of SMAD protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of catenin import into nucleus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of heart induction by regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of methylation-dependent chromatin silencing ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
somatic stem cell maintenance ISO
Inferred from Sequence Orthology
more info
 
stem cell differentiation IDA
Inferred from Direct Assay
more info
 
stem cell maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
trophectodermal cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nuclear transcription factor complex IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
transcriptional repressor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
POU domain, class 5, transcription factor 1
Names
POU domain, class 5, transcription factor 1
octamer-binding protein 3
octamer-binding protein 4
octamer-binding transcription factor 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252452.1NP_001239381.1  POU domain, class 5, transcription factor 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream, in-frame start codon, compared to variant 1. the encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB375270, AW536651, BY390845
    Conserved Domains (2) summary
    smart00352
    Location:174
    Blast Score: 363
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:93151
    Blast Score: 163
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. NM_013633.3NP_038661.2  POU domain, class 5, transcription factor 1 isoform 1

    See proteins identical to NP_038661.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK145321, BY390845, CR974473
    Consensus CDS
    CCDS37600.1
    UniProtKB/Swiss-Prot
    P20263
    Related
    ENSMUSP00000025271, OTTMUSP00000053597, ENSMUST00000025271, OTTMUST00000096009
    Conserved Domains (2) summary
    smart00352
    Location:131205
    Blast Score: 378
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:224282
    Blast Score: 176
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 129X1/SvJ

Genomic

  1. NT_039662.3 Reference GRCm38.p2 129X1/SvJ

    Range
    1824981..1829725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p2 C57BL/6J

    Range
    35506032..35510777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p2 NOD/MrkTac

Genomic

  1. NT_187027.1 Reference GRCm38.p2 NOD/MrkTac

    Range
    1819229..1823763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    39020977..39025724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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