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Pou4f1 POU domain, class 4, transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 18996, updated on 28-May-2016
Official Symbol
Pou4f1provided by MGI
Official Full Name
POU domain, class 4, transcription factor 1provided by MGI
Primary source
MGI:MGI:102525
See related
Ensembl:ENSMUSG00000048349 Vega:OTTMUSG00000032816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Brn3; Brn-3; Brn3a; Brn3.0; Brn-3.0; E130119J07Rik
Orthologs
Location:
14; 14 E1-E3
Exon count:
3
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 14 NC_000080.6 (104461675..104468022, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (104861537..104867216, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35308 Neighboring gene RIKEN cDNA D130079A08 gene Neighboring gene predicted gene, 35362 Neighboring gene predicted gene, 35623 Neighboring gene predicted gene, 34792 Neighboring gene ring finger protein 219

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
cell migration in hindbrain IMP
Inferred from Mutant Phenotype
more info
PubMed 
central nervous system neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
habenula development IMP
Inferred from Mutant Phenotype
more info
PubMed 
innervation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription elongation from RNA polymerase I promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IDA
Inferred from Direct Assay
more info
PubMed 
neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
peripheral nervous system neuron development IGI
Inferred from Genetic Interaction
more info
PubMed 
peripheral nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
peripheral nervous system neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell cycle arrest IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
proprioception involved in equilibrioception IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
suckling behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
trigeminal nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ventricular compact myocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
POU domain, class 4, transcription factor 1
Names
brain-3A
brain-specific homeobox/POU domain protein 3A
brn-3A

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011143.4NP_035273.3  POU domain, class 4, transcription factor 1

    See identical proteins and their annotated locations for NP_035273.3

    Status: VALIDATED

    Source sequence(s)
    AC121997
    Consensus CDS
    CCDS27319.1
    UniProtKB/Swiss-Prot
    P17208
    Related
    ENSMUSP00000060798, OTTMUSP00000043766, ENSMUST00000053016, OTTMUST00000081737
    Conserved Domains (2) summary
    smart00352
    Location:262339
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:358416
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p3 C57BL/6J

    Range
    104461675..104468022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518706.2XP_006518769.1  

    See identical proteins and their annotated locations for XP_006518769.1

    UniProtKB/Swiss-Prot
    P17208
    Conserved Domains (2) summary
    smart00352
    Location:262339
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:358416
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. XM_006518705.2XP_006518768.1  

    See identical proteins and their annotated locations for XP_006518768.1

    UniProtKB/Swiss-Prot
    P17208
    Conserved Domains (2) summary
    smart00352
    Location:262339
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:358416
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RNA

  1. XR_383144.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000036.1 Alternate Mm_Celera

    Range
    103076392..103080281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)