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Pou2f1 POU domain, class 2, transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 18986, updated on 28-May-2016
Official Symbol
Pou2f1provided by MGI
Official Full Name
POU domain, class 2, transcription factor 1provided by MGI
Primary source
MGI:MGI:101898
See related
Ensembl:ENSMUSG00000026565 Vega:OTTMUSG00000034833
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oct1; Otf1; NF-A1; Oct-1; Otf-1; 2810482H01Rik
Orthologs
Location:
1 H2.3; 1 73.21 cM
Exon count:
21
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (165865150..166002672, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (167805603..167932765, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene cellular repressor of E1A-stimulated genes 1 Neighboring gene CD247 antigen Neighboring gene predicted gene, 32999 Neighboring gene heat shock protein 8 pseudogene Neighboring gene predicted gene, 33224 Neighboring gene predicted gene, 39693 Neighboring gene transcription elongation factor B polypeptide 2 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
transcription factor activity, sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
POU domain, class 2, transcription factor 1
Names
octamer-binding protein 1
octamer-binding transcription factor 1
ubiquitous transcription factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011137.3NP_035267.2  POU domain, class 2, transcription factor 1 isoform A

    See identical proteins and their annotated locations for NP_035267.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (A).
    Source sequence(s)
    AC093371, AK028237
    Consensus CDS
    CCDS35760.1
    UniProtKB/Swiss-Prot
    P25425
    UniProtKB/TrEMBL
    A0A0R4J1Z4
    Related
    ENSMUSP00000124738, OTTMUSP00000048257, ENSMUST00000160260, OTTMUST00000088539
    Conserved Domains (2) summary
    smart00352
    Location:304378
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:406462
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. NM_198932.3NP_945150.2  POU domain, class 2, transcription factor 1 isoform Z

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform Z, which is shorter than isoform A.
    Source sequence(s)
    AC093371
    Consensus CDS
    CCDS48430.1
    UniProtKB/TrEMBL
    E9Q6Z8
    Related
    ENSMUSP00000125444, OTTMUSP00000048258, ENSMUST00000160908, OTTMUST00000088540
    Conserved Domains (2) summary
    smart00352
    Location:304378
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:406462
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  3. NM_198933.3NP_945151.2  POU domain, class 2, transcription factor 1 isoform L

    See identical proteins and their annotated locations for NP_945151.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' terminal exon and lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform L, which is shorter and has a distinct N-terminus, compared to isoform A.
    Source sequence(s)
    AC093371
    Consensus CDS
    CCDS15444.1
    UniProtKB/Swiss-Prot
    P25425
    Related
    ENSMUSP00000064000, OTTMUSP00000057876, ENSMUST00000069609, OTTMUST00000103564
    Conserved Domains (2) summary
    smart00352
    Location:293367
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:395451
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  4. NM_198934.3NP_945152.2  POU domain, class 2, transcription factor 1 isoform B

    See identical proteins and their annotated locations for NP_945152.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' terminal exon, compared to variant 1. It encodes isoform B, which is shorter and has a distinct N-terminus, compared to isoform A.
    Source sequence(s)
    AC093371
    Consensus CDS
    CCDS35761.1
    UniProtKB/TrEMBL
    F8VQL7
    Related
    ENSMUSP00000107056, ENSMUST00000111427
    Conserved Domains (2) summary
    smart00352
    Location:293367
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:395451
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    165865150..166002672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238771.1XP_011237073.1  

    Related
    ENSMUSP00000138962, OTTMUSP00000057873, ENSMUST00000184643, OTTMUST00000103561
    Conserved Domains (2) summary
    smart00352
    Location:304378
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:406462
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. XM_011238770.1XP_011237072.1  

    Conserved Domains (2) summary
    smart00352
    Location:304378
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:406462
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  3. XM_006496706.2XP_006496769.1  

    See identical proteins and their annotated locations for XP_006496769.1

    UniProtKB/Swiss-Prot
    P25425
    Conserved Domains (2) summary
    smart00352
    Location:281355
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:383439
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  4. XM_006496704.2XP_006496767.1  

    See identical proteins and their annotated locations for XP_006496767.1

    UniProtKB/Swiss-Prot
    P25425
    Conserved Domains (2) summary
    smart00352
    Location:281355
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:383439
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  5. XM_006496705.1XP_006496768.1  

    See identical proteins and their annotated locations for XP_006496768.1

    UniProtKB/Swiss-Prot
    P25425
    Related
    ENSMUSP00000107057, OTTMUSP00000048259, ENSMUST00000111429, OTTMUST00000088541
    Conserved Domains (2) summary
    smart00352
    Location:281355
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:383439
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  6. XM_011238769.1XP_011237071.1  

    See identical proteins and their annotated locations for XP_011237071.1

    UniProtKB/Swiss-Prot
    P25425
    Conserved Domains (2) summary
    smart00352
    Location:281355
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:383439
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  7. XM_011238767.1XP_011237069.1  

    See identical proteins and their annotated locations for XP_011237069.1

    UniProtKB/Swiss-Prot
    P25425
    Conserved Domains (2) summary
    smart00352
    Location:281355
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:383439
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  8. XM_011238768.1XP_011237070.1  

    See identical proteins and their annotated locations for XP_011237070.1

    UniProtKB/Swiss-Prot
    P25425
    Conserved Domains (2) summary
    smart00352
    Location:281355
    POU; Found in Pit-Oct-Unc transcription factors
    cd00086
    Location:383439
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RNA

  1. XR_373598.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    168311332..168447672 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)