Format

Send to:

Choose Destination

Pon1 paraoxonase 1 [ Mus musculus (house mouse) ]

Gene ID: 18979, updated on 28-May-2016
Official Symbol
Pon1provided by MGI
Official Full Name
paraoxonase 1provided by MGI
Primary source
MGI:MGI:103295
See related
Ensembl:ENSMUSG00000002588 Vega:OTTMUSG00000042263
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pon
Orthologs
Location:
6 1.99 cM; 6 A2
Exon count:
10
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 6 NC_000072.6 (5168090..5193987, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (5118090..5143946, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 9835 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 9A Neighboring gene paraoxonase 3 Neighboring gene paraoxonase 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
acyl-L-homoserine-lactone lactonohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
aryldialkylphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
aryldialkylphosphatase activity ISO
Inferred from Sequence Orthology
more info
 
arylesterase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
arylesterase activity ISO
Inferred from Sequence Orthology
more info
 
calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
high-density lipoprotein particle binding TAS
Traceable Author Statement
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
aromatic compound catabolic process ISO
Inferred from Sequence Orthology
more info
 
blood circulation TAS
Traceable Author Statement
more info
PubMed 
carboxylic acid catabolic process ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol metabolic process TAS
Traceable Author Statement
more info
PubMed 
organophosphate catabolic process ISO
Inferred from Sequence Orthology
more info
 
phosphatidylcholine metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transporter activity ISO
Inferred from Sequence Orthology
more info
 
response to fluoride ISO
Inferred from Sequence Orthology
more info
 
response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
blood microparticle ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
spherical high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
serum paraoxonase/arylesterase 1
Names
A-esterase 1
PON 1
aromatic esterase 1
serum aryldialkylphosphatase 1
NP_035264.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011134.3NP_035264.2  serum paraoxonase/arylesterase 1 precursor

    See identical proteins and their annotated locations for NP_035264.2

    Status: VALIDATED

    Source sequence(s)
    AC074225, AI194741, BB870662, U32684
    Consensus CDS
    CCDS19898.1
    UniProtKB/Swiss-Prot
    P52430
    Related
    ENSMUSP00000002663, OTTMUSP00000062114, ENSMUST00000002663, OTTMUST00000111121
    Conserved Domains (2) summary
    pfam01731
    Location:168253
    Arylesterase; Arylesterase
    pfam08450
    Location:129308
    SGL; SMP-30/Gluconolaconase/LRE-like region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p3 C57BL/6J

    Range
    5168090..5193987 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505011.1XP_006505074.1  

    See identical proteins and their annotated locations for XP_006505074.1

    Related
    ENSMUSP00000135195, OTTMUSP00000062115, ENSMUST00000177159, OTTMUST00000111122
    Conserved Domains (1) summary
    cl22863
    Location:159186
    Str_synth; Strictosidine synthase
  2. XM_011241049.1XP_011239351.1  

    Conserved Domains (1) summary
    pfam01731
    Location:168253
    Arylesterase; Arylesterase

Alternate Mm_Celera

Genomic

  1. AC_000028.1 Alternate Mm_Celera

    Range
    5314337..5340485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)