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    ndx-4 NuDiX family [ Caenorhabditis elegans ]

    Gene ID: 189639, updated on 6-May-2012
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    Summary

    Gene symbol
    ndx-4
    Gene description
    NuDiX family
    Primary source
    WormBase:WBGene00003581
    Locus tag
    Y37H9A.6
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
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    Genomic context

    Location :
    chromosome: I
    Sequence :
    Chromosome: I; NC_003279.6 (13792632..13794139, complement)
    See ndx-4 in MapViewer

    Chromosome I - NC_003279.6Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability. Arczewska KD, et al. DNA Repair (Amst), 2011 Feb 7. PMID 21111690.
    2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431.
    3. The Gene Ontology Annotation (GOA) project: implementation of GO in SWISS-PROT, TrEMBL, and InterPro. Camon E, et al. Genome Res, 2003 Apr. PMID 12654719.
    4. The InterPro Database, 2003 brings increased coverage and new features. Mulder NJ, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520011.
    5. Cloning, characterisation and crystallisation of a diadenosine 5',5"'-P(1),P(4)-tetraphosphate pyrophosphohydrolase from Caenorhabditis elegans. Abdelghany HM, et al. Biochim Biophys Acta, 2001 Nov 26. PMID 11738085.

    See all (6) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. NDX-4 exhibits both hallmarks of a MutT-type enzyme with an ability to hydrolyze 8-oxodGTP and suppress the Escherichia coli mutT mutator phenotype.NDX-4 contributes to genomic stability in vivo in C. elegans.
      Title: Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:54272 BioGRID:40862 rps-0    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Homology

    • Homologs of the ndx-4 gene: The ndx-4 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, and mosquito.

    Pathways from BioSystems

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    bis(5'-nucleosyl)-tetraphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    induction of apoptosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
    		  
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    General protein information

    Names
    NuDiX family member (ndx-4)
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.6

      Range
      13792632..13794139, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061012.3 → NP_493413.1  NuDiX family member (ndx-4) [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U2M7
      Conserved Domains (1) summary
      cd03428
      Location:3 – 133
      Blast Score: 421
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL032625.1 CAB63351.1
    genomic BX284601.3 CAB63351.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    1KT9_A.1 GenPept
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    Additional Links

    Gene LinkOut

      Supplemental Content