Plg plasminogen [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Plgprovided by MGI
Official Full Name: plasminogenprovided by MGI
Primary source: MGI:97620
See related: Ensembl:ENSMUSG00000059481
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pg; AI649309

Genomic context

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Location :: 17 A1; 17 8.5 cM

Sequence :: Chromosome: 17; NC_000083.6 (12378609..12419384)

See Plg in Epigenomics, MapViewer

Chromosome 17 - NC_000083.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

In summary, these data indicate that plasmin-driven fibrinolysis facilitates tumor growth by maintaining patency of the tumor vasculature.
Title: Plasmin-driven fibrinolysis facilitates skin tumor growth in a gender-dependent manner.
Plasmin is essential in preventing periodontitis in mice
Title: Plasmin is essential in preventing periodontitis in mice.
found that male Plg knockout mice, but not their female counterparts, exhibited normochromic normocytic anemia
Title: Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis.
Dengue virus (DENV)-immunized mouse sera demonstrates antibody binding to both DENV and Plg when compared with nonimmune control mouse serum.
Title: Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation.
a novel mechanism that plasminogen regulates MMP-9-dependent CXCR4 expression to facilitate hematopoietic progenitor and stem cell mobilization in response to granulocyte colony-stimulating factor.
Title: Plasminogen regulates stromal cell-derived factor-1/CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9.
A phenotypic overlap, defined as an additional delay in wound healing in the double-deficient mice compared to the individual single-deficient mice, between MMP-13 and the plasminogen activation system.
Title: Phenotypic overlap between MMP-13 and the plasminogen activation system during wound healing in mice.
Plasmin plays an essential role in amplification of psoriasiform skin inflammation.
Title: Plasmin plays an essential role in amplification of psoriasiform skin inflammation in mice.
in endothelial cells, plasmin specifically induces activation of conventional PKC, which phosphorylates serine 11 and serine 25 of A2, triggering dissociation of the (A2.p11)(2) tetramer.
Title: Feedback regulation of endothelial cell surface plasmin generation by PKC-dependent phosphorylation of annexin A2.
Plasminogen is highly expressed in specific populations of hippocampal, cortical, and hypothalamic neurons, and plasminogen-containing vesicles are mainly observed at neuronal somata.
Title: Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus.
The interaction of sM6P/IGF2R with Plg may be an important regulatory mechanism to inhibit migration of cells using the uPA/uPAR system.
Title: Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation.

Submit: New GeneRIF Correction See all (63)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
NP_032903.2	NP_031566.3	Bdnf		BIND	PubMed	Plasmin interacts with BDNF.
NP_032903.2	NP_035300.1	Prnp		BIND	PubMed	PrPSc interacts with Plg. This interaction was modeled on a demonstrated interaction between mouse PrPSc and human Plg.

Pathways from BioSystems

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Activation of Matrix Metalloproteinases, organism-specific biosystem (from REACTOME)
Activation of Matrix Metalloproteinases, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Blood Clotting Cascade, organism-specific biosystem (from WikiPathways)
Blood Clotting Cascade, organism-specific biosystemCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered ...
Complement and Coagulation Cascades, organism-specific biosystem (from WikiPathways)
Complement and Coagulation Cascades, organism-specific biosystem
Complement and Coagulation Cascades
Complement and coagulation cascades, organism-specific biosystem (from KEGG)
Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
Complement and coagulation cascades, conserved biosystem (from KEGG)
Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
Degradation of the extracellular matrix, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dissolution of Fibrin Clot, organism-specific biosystem (from REACTOME)
Dissolution of Fibrin Clot, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Extracellular matrix organization, organism-specific biosystem (from REACTOME)
Extracellular matrix organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Influenza A, organism-specific biosystem (from KEGG)
Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Influenza A, conserved biosystem (from KEGG)
Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
LDL-mediated lipid transport, organism-specific biosystem (from REACTOME)
LDL-mediated lipid transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Lipid digestion, mobilization, and transport, organism-specific biosystem (from REACTOME)
Lipid digestion, mobilization, and transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Lipoprotein metabolism, organism-specific biosystem (from REACTOME)
Lipoprotein metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
Neuroactive ligand-receptor interaction, organism-specific biosystem
Neuroactive ligand-receptor interaction
Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
Neuroactive ligand-receptor interaction, conserved biosystem
Neuroactive ligand-receptor interaction
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet degranulation, organism-specific biosystem (from REACTOME)
Platelet degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystem (from REACTOME)
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by PDGF, organism-specific biosystem (from REACTOME)
Signaling by PDGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Staphylococcus aureus infection, organism-specific biosystem (from KEGG)
Staphylococcus aureus infection, organism-specific biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...
Staphylococcus aureus infection, conserved biosystem (from KEGG)
Staphylococcus aureus infection, conserved biosystemStaphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the ef...

General gene information

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Markers

PLG_3841 (e-PCR)
- UniSTS:462421

Plg (e-PCR), detects polymorphism
- UniSTS:144222

UniSTS:498273 (e-PCR)
- UniSTS:498273

Plg (e-PCR), detects polymorphism
- UniSTS:498273

Plg (e-PCR), detects polymorphism
- UniSTS:525934

J04766 (e-PCR)
- UniSTS:124856

D17Mit114 (e-PCR), detects polymorphism
- UniSTS:127950

AI649309 (e-PCR)
- UniSTS:186084

Homology

Homologs of the Plg gene: The Plg gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
apolipoprotein binding	ISO Inferred from Sequence Orthology more info
catalytic activity	IEA Inferred from Electronic Annotation more info
cell surface binding	ISO Inferred from Sequence Orthology more info
endopeptidase activity	ISO Inferred from Sequence Orthology more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
peptidase activity	IEA Inferred from Electronic Annotation more info
protein domain specific binding	ISO Inferred from Sequence Orthology more info
serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
apoptotic process	IDA Inferred from Direct Assay more info	PubMed
blood coagulation	ISO Inferred from Sequence Orthology more info
extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
fibrinolysis	IEA Inferred from Electronic Annotation more info
hemostasis	IEA Inferred from Electronic Annotation more info
induction of apoptosis	IDA Inferred from Direct Assay more info	PubMed
labyrinthine layer blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
mononuclear cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
muscle cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of angiogenesis	TAS Traceable Author Statement more info	PubMed
negative regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
negative regulation of fibrinolysis	ISO Inferred from Sequence Orthology more info
positive regulation of fibrinolysis	ISO Inferred from Sequence Orthology more info
proteolysis	IEA Inferred from Electronic Annotation more info
proteolysis involved in cellular protein catabolic process	ISO Inferred from Sequence Orthology more info
tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
tissue remodeling	IEA Inferred from Electronic Annotation more info
trophoblast giant cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	ISO Inferred from Sequence Orthology more info
extrinsic to external side of plasma membrane	ISO Inferred from Sequence Orthology more info
extrinsic to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: plasminogen

Names: plasminogen; angiostatin; plasmin heavy chain A; plasmin light chain B

NP_032903.3

EC 3.4.21.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008877.3 → NP_032903.3 plasminogen precursor

Status: VALIDATED

Source sequence(s)

AK132254, BY131661, J04766

Consensus CDS

CCDS28390.1

UniProtKB/Swiss-Prot

P20918

UniProtKB/TrEMBL

Q3V1T9

Related

ENSMUSP00000014578, ENSMUST00000014578

Conserved Domains (3) summary

cd00108
Location:375 – 455
Blast Score: 298

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd01099
Location:38 – 97
Blast Score: 141

PAN_AP_HGF; Subfamily of PAN/APPLE-like domains; present in N-terminal (N) domains of plasminogen/hepatocyte growth factor proteins, and various proteins found in Bilateria, such as leech anti-platelet proteins. PAN/APPLE domains fulfill diverse biological functions ...

cd00190
Location:582 – 807
Blast Score: 698

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000083.6 Reference GRCm38.p1 C57BL/6J

Range

12378609..12419384

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000039.1 Alternate Mm_Celera

Range

12409327..12450146

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01131128.1 (9792..50611)	None
genomic	AC087901.21 (8201..48976)	None	C57BL/6J
genomic	AF481053.1	AAM22156.1	129/Sv
genomic	AY134430.1	AAN15805.1	129/SvJ
genomic	CH466619.2	EDL02061.1	mixed
		EDL02062.1	mixed
		EDL02063.1	mixed
		EDL02064.1	mixed
		EDL02065.1	mixed
		EDL02066.1	mixed
		EDL02067.1	mixed
		EDL02068.1	mixed
		EDL02069.1	mixed
		EDL02070.1	mixed
		EDL02071.1	mixed
		EDL02072.1	mixed
mRNA	AK040840.1	None	C57BL/6J
mRNA	AK132254.1	BAE21060.1	C57BL/6J
mRNA	AY424276.1	AAR07361.1	Kunming
mRNA	BC014773.1	AAH14773.1	FVB/N
mRNA	BC057186.1	AAH57186.1	FVB/N
mRNA	BY131661.1	None	C57BL/6J
mRNA	J04766.1	AAA50168.1	C57BL/6