GPR183 G protein-coupled receptor 183 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: GPR183provided by HGNC
Official Full Name: G protein-coupled receptor 183provided by HGNC
Primary source: HGNC:3128
Locus tag: RP11-461N23.2
See related: Ensembl:ENSG00000169508; HPRD:12040; MIM:605741; Vega:OTTHUMG00000017263
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EBI2
Summary: This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 13q32.3

Sequence :: Chromosome: 13; NC_000013.10 (99946789..99959749, complement)

See GPR183 in Epigenomics, MapViewer

Chromosome 13 - NC_000013.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

This model of ligand docking yields important structural insight into the molecular mechanisms mediating EBI2 function.
Title: Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site.
Data indicate that EBI2 expression modulates CXCL13 binding affinity to CXCR5.
Title: EBI2 regulates CXCL13-mediated responses by heterodimerization with CXCR5.
Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183).
Title: Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183).
REVIEW: functional properties and in vivo biology
Title: EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors.
Structural motifs of importance for the constitutive activity of EBI2: analysis of receptor activation in the absence of an agonist.
Title: Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist.
Based on the constitutive signaling and cellular expression pattern of EBI2, it is suggested that it may function in conjunction with BILF1 in the reprogramming of the cell during EBV infection
Title: Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity.

Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
P32249	Q13330	MTA1	HPRD	PubMed
BioGRID:108212	BioGRID:114562	MTA1	BioGRID	PubMed	Two-hybrid
BioGRID:108212	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Pathways from BioSystems

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GPCRs, Other, organism-specific biosystem (from WikiPathways)
GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...

General gene information

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Markers

WI-18855 (e-PCR)
- UniSTS:67407

G15934 (e-PCR)
- UniSTS:48235

EBI2_25 (e-PCR)
- UniSTS:277181

L08177 (e-PCR)
- UniSTS:4047

Homology

Homologs of the GPR183 gene: The GPR183 gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, and chicken.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
G-protein coupled purinergic nucleotide receptor activity	IEA Inferred from Electronic Annotation more info
G-protein coupled receptor activity	TAS Traceable Author Statement more info	PubMed
oxysterol binding	IDA Inferred from Direct Assay more info

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	IDA Inferred from Direct Assay more info
humoral immune response	ISS Inferred from Sequence or Structural Similarity more info
immune response	TAS Traceable Author Statement more info	PubMed
mature B cell differentiation involved in immune response	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of B cell proliferation	IDA Inferred from Direct Assay more info
positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info

Component	Evidence Code	Pubs
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: G-protein coupled receptor 183

Names: G-protein coupled receptor 183; EBV-induced G-protein coupled receptor 2; epstein-Barr virus-induced G-protein coupled receptor 2; Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004951.4 → NP_004942.1 G-protein coupled receptor 183

Status: REVIEWED

Source sequence(s)

AK313443, AW574697, BC020752

Consensus CDS

CCDS9492.1

UniProtKB/Swiss-Prot

P32249

Related

ENSP00000365596, OTTHUMP00000018611, ENST00000376414, OTTHUMT00000045582

Conserved Domains (2) summary

pfam00001
Location:54 – 308
Blast Score: 502

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:43 – 161
Blast Score: 105

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000013.10 Reference GRCh37.p10 Primary Assembly

Range

99946789..99959749, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000145.1 Alternate HuRef

Range

80541169..80554130, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018924.1 Alternate CHM1_1.0

Range

80872931..80885892, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01027126.1 (8246..21207)	None
genomic	AL160155.19 (91876..104836)	None
genomic	AMYH01005326.1 (207536..220497)	None
genomic	CH471085.1	EAX09018.1
		EAX09019.1
genomic	JA738717.1	CCF77011.1
mRNA	AI740732.1	None
mRNA	AK223390.1	BAD97110.1
mRNA	AK292091.1	BAF84780.1
mRNA	AK313443.1	BAG36232.1
mRNA	AW402166.1	None
mRNA	AW574697.1	None
mRNA	AW575283.1	None
mRNA	BC020752.1	AAH20752.1
mRNA	L08177.1	AAA35924.1
other-genetic	DQ891368.2	ABM82294.1
other-genetic	DQ894548.2	ABM85474.1