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Plcb2 phospholipase C, beta 2 [ Mus musculus (house mouse) ]

Gene ID: 18796, updated on 18-May-2013

Summary

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Official Symbol: Plcb2provided by MGI
Official Full Name: phospholipase C, beta 2provided by MGI
Primary source: MGI:107465
Locus tag: RP23-172B16.2
See related: Ensembl:ENSMUSG00000040061; Vega:OTTMUSG00000015372
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AI550384; B230399N12; B230205M18Rik

Genomic context

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Location :: 2 E5; 2 59.43 cM

Sequence :: Chromosome: 2; NC_000068.7 (118707517..118728438, complement)

See Plcb2 in Epigenomics, MapViewer

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
Title: GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
A PLCbeta/PI3Kgamma-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis.
Title: A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis.
The beta2 isoform mediates close to one-half the chemokine-induced calcium signal in resting and anti-IgM-activated B cells.
Title: Pathway-selective suppression of chemokine receptor signaling in B cells by LPS through downregulation of PLC-β2.
Taurine supplementation increases insulin secretion, favouring both influx and internal mobilisation of Ca2+; these effects seem to involve multiple pathways.
Title: Taurine supplementation: involvement of cholinergic/phospholipase C and protein kinase A pathways in potentiation of insulin secretion and Ca2+ handling in mouse pancreatic islets.
suppression of PLCbeta2 plays an important role in switching M1 macrophages into an M2-like state.
Title: Suppression of PLCbeta2 by endotoxin plays a role in the adenosine A(2A) receptor-mediated switch of macrophages from an inflammatory to an angiogenic phenotype.
Essential sensory transduction component from taste GPCRs for sweet, bitter, umami tastes
Title: Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.
Transgenic PLCb2-GFP mice label taste bud cells and olfactory microvillar cells. Immune cells not examined.
Title: Faithful expression of GFP from the PLCbeta2 promoter in a functional class of taste receptor cells.
loss of PLCbeta2 and PLCbeta3 significantly impaired T cell migration.
Title: Phospholipase cbeta is critical for T cell chemotaxis.
Expression of Plcb2 was studied in a cell line during myoblast differentiation.
Title: Expression of phospholipase C beta family isoenzymes in C2C12 myoblasts during terminal differentiation.
confirm role for PLCbeta2 in taste responsiveness to sucrose and to low- to midrange concentrations of quinine and denatonium, and suggest that higher concentrations of the latter two compounds can engage a PLCbeta2-independent taste transduction pathway
Title: PLCbeta2-independent behavioral avoidance of prototypical bitter-tasting ligands.

Submit: New GeneRIF Correction See all (12)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

Pathways from BioSystems

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Activation of Kainate Receptors upon glutamate binding, organism-specific biosystem (from REACTOME)
Activation of Kainate Receptors upon glutamate binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
African trypanosomiasis, organism-specific biosystem (from KEGG)
African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
African trypanosomiasis, conserved biosystem (from KEGG)
African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
Alzheimer's disease, organism-specific biosystem (from KEGG)
Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Alzheimer's disease, conserved biosystem (from KEGG)
Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Amoebiasis, organism-specific biosystem (from KEGG)
Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Amoebiasis, conserved biosystem (from KEGG)
Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Calcium signaling pathway, organism-specific biosystem (from KEGG)
Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
Calcium signaling pathway, conserved biosystem (from KEGG)
Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
Carbohydrate digestion and absorption, organism-specific biosystem (from KEGG)
Carbohydrate digestion and absorption, organism-specific biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
Carbohydrate digestion and absorption, conserved biosystem (from KEGG)
Carbohydrate digestion and absorption, conserved biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Chemokine signaling pathway, organism-specific biosystem (from KEGG)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, organism-specific biosystem (from WikiPathways)
Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Chemokine signaling pathway, conserved biosystem (from KEGG)
Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
Cholinergic synapse, organism-specific biosystem (from KEGG)
Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
Circadian entrainment, organism-specific biosystem (from KEGG)
Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
Circadian entrainment, conserved biosystem (from KEGG)
Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
D-myo-inositol (1,4,5)-trisphosphate biosynthesis, organism-specific biosystem (from BIOCYC)
D-myo-inositol (1,4,5)-trisphosphate biosynthesis, organism-specific biosystem
D-myo-inositol (1,4,5)-trisphosphate biosynthesis
D-myo-inositol-5-phosphate metabolism, organism-specific biosystem (from BIOCYC)
D-myo-inositol-5-phosphate metabolism, organism-specific biosystem
D-myo-inositol-5-phosphate metabolism
Dopaminergic synapse, organism-specific biosystem (from KEGG)
Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
Dopaminergic synapse, conserved biosystem (from KEGG)
Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem (from KEGG)
Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
Endocrine and other factor-regulated calcium reabsorption, conserved biosystem (from KEGG)
Endocrine and other factor-regulated calcium reabsorption, conserved biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
Estrogen signaling pathway, organism-specific biosystem (from KEGG)
Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
Estrogen signaling pathway, conserved biosystem (from KEGG)
Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
G alpha (q) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G beta:gamma signalling through PLC beta, organism-specific biosystem (from REACTOME)
G beta:gamma signalling through PLC beta, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G-protein beta:gamma signalling, organism-specific biosystem (from REACTOME)
G-protein beta:gamma signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G-protein mediated events, organism-specific biosystem (from REACTOME)
G-protein mediated events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gap junction, organism-specific biosystem (from KEGG)
Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Gap junction, conserved biosystem (from KEGG)
Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Gastric acid secretion, organism-specific biosystem (from KEGG)
Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
Gastric acid secretion, conserved biosystem (from KEGG)
Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glutamatergic synapse, organism-specific biosystem (from KEGG)
Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
Glutamatergic synapse, conserved biosystem (from KEGG)
Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
GnRH signaling pathway, organism-specific biosystem (from KEGG)
GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
GnRH signaling pathway, conserved biosystem (from KEGG)
GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
Huntington's disease, organism-specific biosystem (from KEGG)
Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Huntington's disease, conserved biosystem (from KEGG)
Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Inositol phosphate metabolism, organism-specific biosystem (from KEGG)
Inositol phosphate metabolism, organism-specific biosystem
Inositol phosphate metabolism
Inositol phosphate metabolism, organism-specific biosystem (from REACTOME)
Inositol phosphate metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Inositol phosphate metabolism, conserved biosystem (from KEGG)
Inositol phosphate metabolism, conserved biosystem
Inositol phosphate metabolism
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4, organism-specific biosystem (from KEGG)
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Lipid metabolism
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4, conserved biosystem (from KEGG)
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Lipid metabolism
Insulin secretion, organism-specific biosystem (from KEGG)
Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
Integration of energy metabolism, organism-specific biosystem (from REACTOME)
Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Long-term depression, organism-specific biosystem (from KEGG)
Long-term depression, organism-specific biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
Long-term depression, conserved biosystem (from KEGG)
Long-term depression, conserved biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
Long-term potentiation, organism-specific biosystem (from KEGG)
Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
Long-term potentiation, conserved biosystem (from KEGG)
Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
Melanogenesis, organism-specific biosystem (from KEGG)
Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
Melanogenesis, conserved biosystem (from KEGG)
Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystem (from WikiPathways)
MicroRNAs in cardiomyocyte hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
Neuronal System, organism-specific biosystem (from REACTOME)
Neuronal System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Opioid Signalling, organism-specific biosystem (from REACTOME)
Opioid Signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PIP metabolism, organism-specific biosystem (from BIOCYC)
PIP metabolism, organism-specific biosystem
PIP metabolism
PLC beta mediated events, organism-specific biosystem (from REACTOME)
PLC beta mediated events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pancreatic secretion, organism-specific biosystem (from KEGG)
Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
Pancreatic secretion, conserved biosystem (from KEGG)
Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
Phosphatidylinositol signaling system, organism-specific biosystem (from KEGG)
Phosphatidylinositol signaling system, organism-specific biosystem
Phosphatidylinositol signaling system
Phosphatidylinositol signaling system, conserved biosystem (from KEGG)
Phosphatidylinositol signaling system, conserved biosystem
Phosphatidylinositol signaling system
Presynaptic function of Kainate receptors, organism-specific biosystem (from REACTOME)
Presynaptic function of Kainate receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Insulin Secretion, organism-specific biosystem (from REACTOME)
Regulation of Insulin Secretion, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Insulin Secretion by Acetylcholine, organism-specific biosystem (from REACTOME)
Regulation of Insulin Secretion by Acetylcholine, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1), organism-specific biosystem (from REACTOME)
Regulation of Insulin Secretion by Fatty Acids Bound to GPR40 (FFAR1), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Insulin Secretion by Free Fatty Acids, organism-specific biosystem (from REACTOME)
Regulation of Insulin Secretion by Free Fatty Acids, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
Salivary secretion, organism-specific biosystem (from KEGG)
Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
Salivary secretion, conserved biosystem (from KEGG)
Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
Serotonergic synapse, organism-specific biosystem (from KEGG)
Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Synthesis of IP3 and IP4 in the cytosol, organism-specific biosystem (from REACTOME)
Synthesis of IP3 and IP4 in the cytosol, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Taste transduction, organism-specific biosystem (from KEGG)
Taste transduction, organism-specific biosystemAll taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na...
Taste transduction, conserved biosystem (from KEGG)
Taste transduction, conserved biosystemAll taste pathways are proposed to converge on common elements that mediate a rise in intracellular Ca2+ followed by neurotransmitter release. Na+ salt depolarizes taste cells by passive influx of Na...
Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
Transmission across Chemical Synapses, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
Vascular smooth muscle contraction, conserved biosystem (from KEGG)
Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
Wnt signaling pathway, organism-specific biosystem (from KEGG)
Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt signaling pathway, conserved biosystem (from KEGG)
Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
phospholipases, organism-specific biosystem (from BIOCYC)
phospholipases, organism-specific biosystem
phospholipases

General gene information

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Markers

Plcb2 (e-PCR), detects polymorphism
- UniSTS:532519

Plcb2 (e-PCR), detects polymorphism
- UniSTS:546951

AI550384 (e-PCR)
- UniSTS:185487

Homology

Homologs of the Plcb2 gene: The Plcb2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, and chicken.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
G-protein beta/gamma-subunit complex binding	ISO Inferred from Sequence Orthology more info
calcium ion binding	IEA Inferred from Electronic Annotation more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
phospholipase C activity	ISO Inferred from Sequence Orthology more info
phospholipid binding	ISO Inferred from Sequence Orthology more info
phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info
signal transducer activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
detection of chemical stimulus involved in sensory perception of bitter taste	ISO Inferred from Sequence Orthology more info
intracellular signal transduction	ISO Inferred from Sequence Orthology more info
lipid catabolic process	IEA Inferred from Electronic Annotation more info
lipid metabolic process	IEA Inferred from Electronic Annotation more info
sensory perception of bitter taste	IMP Inferred from Mutant Phenotype more info	PubMed
signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
G-protein beta/gamma-subunit complex	ISO Inferred from Sequence Orthology more info
Golgi apparatus	ISO Inferred from Sequence Orthology more info
cytoplasmic part	IDA Inferred from Direct Assay more info
cytosol	ISO Inferred from Sequence Orthology more info
plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; PLC-beta-2; phospholipase C-beta-2; phosphoinositide phospholipase C-beta-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2

NP_808236.2

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177568.2 → NP_808236.2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Status: VALIDATED

Source sequence(s)

AK045469, AK046511, AL772255, BB620972, BB635904

Consensus CDS

CCDS16582.1

UniProtKB/Swiss-Prot

A3KGF7

Related

ENSMUSP00000099583, OTTMUSP00000016375, ENSMUST00000102524, OTTMUST00000036437

Conserved Domains (8) summary

pfam09279
Location:220 – 311
Blast Score: 254

efhand_like; Phosphoinositide-specific phospholipase C, efhand-like

cd00275
Location:682 – 803
Blast Score: 334

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd01248
Location:14 – 133
Blast Score: 260

PH_PLC; Phospholipase C (PLC) pleckstrin homology (PH) domain

cd08591
Location:311 – 464
Blast Score: 863

PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta

PLN02222
Location:219 – 801
Blast Score: 483

PLN02222; phosphoinositide phospholipase C 2

pfam08703
Location:972 – 1151
Blast Score: 559

PLC-beta_C; PLC-beta C terminal

cl11531
Location:1038 – 1117
Blast Score: 84

DUF904; Protein of unknown function (DUF904)

cl14615
Location:544 – 650
Blast Score: 555

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000068.7 Reference GRCm38.p1 C57BL/6J

Range

118707517..118728438, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000024.1 Alternate Mm_Celera

Range

119861823..119882734, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01019954.1 (81522..102433)	None
genomic	AL772255.12 (2760..23681)	None
genomic	AY902324.1	AAX90609.1	CAST/EiJ
genomic	CH466519.1	EDL27914.1	mixed
		EDL27915.1	mixed
mRNA	AF022802.1	AAD01750.1	C57BL
mRNA	AK031502.1	BAE20476.1	C57BL/6J
mRNA	AK045469.1	BAC32384.1	C57BL/6J
mRNA	AK046511.1	None	C57BL/6J
mRNA	AK169442.1	BAE41180.1	C57BL/6J
mRNA	AK183253.1	None
mRNA	AK211847.1	None
mRNA	AK212238.1	None
mRNA	BB620972.1	None	C57BL/6J
mRNA	BB635904.1	None	C57BL/6J
mRNA	BC019788.1	None	CZECHII
mRNA	BC038048.1	None	FVB/N
mRNA	BC145249.1	AAI45250.1
other-genetic	BC156752.1	AAI56753.1