Plau plasminogen activator, urokinase [Mus musculus] - Gene

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Summary

Official Symbol: Plauprovided by MGI
Official Full Name: plasminogen activator, urokinaseprovided by MGI
Primary source: MGI:97611
See related: Ensembl:ENSMUSG00000021822
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: uPA; u-PA

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Genomic context

Location :: 14 A3; 14 2.5 cM

Sequence :: Chromosome: 14; NC_000080.6 (20836662..20843388)

See Plau in Epigenomics, MapViewer

Chromosome 14 - NC_000080.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

suggest that uPA promotes cell migration by binding to fibulin-5, initiating its cleavage by plasmin, which leads to its dissociation from beta1-integrin and thereby unblocks the capacity of integrin to facilitate cell motility
Title: Fibulin-5 binds urokinase-type plasminogen activator and mediates urokinase-stimulated β1-integrin-dependent cell migration.
The uPA-uPAR axis has no effect on the formation of Ang II-induced abdominal aortic aneurysms, but uPA deficiency promotes aneurysmal rupture.
Title: Urokinase-type plasminogen activator deficiency in bone marrow-derived cells augments rupture of angiotensin II-induced abdominal aortic aneurysms.
Urokinase type plasminogen activator, at concentrations found under pathological conditions, reduced pulmonary arterial contractility and increased permeability though the activation of NMDA-R1.
Title: Urokinase plasminogen activator regulates pulmonary arterial contractility and vascular permeability in mice.
uPA acts in a cell signaling manner via binding to its receptor uPAR rather than as a protease.
Title: Plasminogen activator promotes recovery following spinal cord injury.
There is an essential functional dependency between MMP9 and uPA during gestation and tissue repair.
Title: Concomitant lack of MMP9 and uPA disturbs physiological tissue remodeling.
contributes to heterogeneity of macrophages at the border of damaged site during liver repair
Title: Urokinase-type plasminogen activator contributes to heterogeneity of macrophages at the border of damaged site during liver repair in mice.
Urokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase.
Title: Urokinase-type plasminogen activator (uPA) induces pulmonary microvascular endothelial permeability through low density lipoprotein receptor-related protein (LRP)-dependent activation of endothelial nitric-oxide synthase.
A phenotypic overlap, defined as an additional delay in wound healing in the double-deficient mice compared to the individual single-deficient mice, between MMP-13 and the plasminogen activation system.
Title: Phenotypic overlap between MMP-13 and the plasminogen activation system during wound healing in mice.
mechanisms of uPA/uPAR/plasminogen-accelerated atherosclerosis and aneurysm formation
Title: Mechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis: role of the uPA receptor and S100A8/A9 proteins.
The interaction of sM6P/IGF2R with Plg may be an important regulatory mechanism to inhibit migration of cells using the uPA/uPAR system.
Title: Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation.

Submit: New GeneRIF Correction See all (80)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation
Targeted (knock-in) (1) 1 citation

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:202230	BioGRID:198143	Apc		BioGRID	PubMed	Phenotypic Suppression

Function	Evidence Code	Pubs
catalytic activity	IEA Inferred from Electronic Annotation more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
kinase activity	IEA Inferred from Electronic Annotation more info
peptidase activity	IEA Inferred from Electronic Annotation more info
serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
angiogenesis	ISO Inferred from Sequence Orthology more info
phosphorylation	IEA Inferred from Electronic Annotation more info
proteolysis	IEA Inferred from Electronic Annotation more info
regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
regulation of receptor activity	ISO Inferred from Sequence Orthology more info
regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
regulation of smooth muscle cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
skeletal muscle tissue regeneration	ISO Inferred from Sequence Orthology more info
smooth muscle cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cell surface	ISO Inferred from Sequence Orthology more info
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: urokinase-type plasminogen activator

Names: urokinase-type plasminogen activator; U-plasminogen activator

NP_032899.1

EC 3.4.21.73

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008873.3 → NP_032899.1 urokinase-type plasminogen activator precursor

Status: VALIDATED

Source sequence(s)

BY320655, X02389

Consensus CDS

CCDS26858.1

UniProtKB/Swiss-Prot

P06869

UniProtKB/TrEMBL

Q0VBA8

Related

ENSMUSP00000022368, ENSMUST00000022368

Conserved Domains (2) summary

cd00108
Location:68 – 153
Blast Score: 218

KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

cd00190
Location:180 – 424
Blast Score: 630

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000080.6 Reference GRCm38 C57BL/6J

Range

20836662..20843388

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000036.1 Alternate Mm_Celera

Range

17217270..17223995

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC121599.3 (207290..213971)	None
genomic	CH466613.2	EDL01484.1	mixed
genomic	M17922.1	AAA40539.1
mRNA	AK054349.1	BAC35743.2	C57BL/6J
mRNA	BC120709.1	AAI20710.1
mRNA	BC120713.1	AAI20714.1
mRNA	BC145037.1	None
mRNA	BY320655.1	None
mRNA	X02389.1	CAA26231.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P06869.1	GenPept	UniProtKB/Swiss-Prot:P06869
Q0VBA8	GenPept	UniProtKB/TrEMBL:Q0VBA8
Q8C6L2	GenPept	UniProtKB/TrEMBL:Q8C6L2