Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 [Mus musculus] - Gene

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Summary

Official Symbol: Serpine1provided by MGI
Official Full Name: serine (or cysteine) peptidase inhibitor, clade E, member 1provided by MGI
Primary source: MGI:97608
See related: Ensembl:ENSMUSG00000037411
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAI1; PAI-1; Planh1

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Genomic context

Location :: 5 G2; 5

Sequence :: Chromosome: 5; NC_000071.6 (137061504..137072272, complement)

See Serpine1 in Epigenomics, MapViewer

Chromosome 5 - NC_000071.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These findings suggest that PAI-1 is protective for aneurysm formation in the elastase model of abdominal aortic aneurysm
Title: Increased PAI-1 in females compared with males is protective for abdominal aortic aneurysm formation in a rodent model.
PAI-1 expression in macrophages was highly up-regulated by CpG-ODN-stimulation in vitro and in vivo.
Title: Novel regulatory mechanism and functional implication of plasminogen activator inhibitor-1 (PAI-1) expression in CpG-ODN-stimulated macrophages.
Results from a number of studies, especially those using PAI-1 deficient mouse models, have demonstrated that PAI-1 is multifunctional protein which appears to both prevent and enhance various disease states. [REVIEW]
Title: Effects of altered plasminogen activator inhibitor-1 expression on cardiovascular disease.
This study identifies the extracellular PAI-1/urokinase-type plasminogen activator (uPA) balance as an important regulator of microribonucleic acid (miR)-21 biogenesis, controlling age-associated muscle fibrosis and dystrophy progression.
Title: PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy.
Concentrations of plasma PAI-1 and levels of its mRNA expression in the liver were significantly elevated in accordance with hepatic PPARgamma1 and PPARgamma2 mRNA accumulation in genetically diabetic db/db mice
Title: PPARγ activation induces acute PAI-1 gene expression in the liver but not in adipose tissues of diabetic model mice.
Findings implicate role for cAMP in regulation of the gene expression of tissue factor and plasminogen activator inhibitor-1 in adipocytes.
Title: Effect of dibutyryl cyclic adenosine monophosphate on the gene expression of plasminogen activator inhibitor-1 and tissue factor in adipocytes.
this study thus reveals a novel role of PAI-1 in infection caused by NTHi, one of the most common gram-negative bacterial pathogens in respiratory systems.
Title: Critical role of type 1 plasminogen activator inhibitor (PAI-1) in early host defense against nontypeable Haemophilus influenzae (NTHi) infection.
ExoU was shown to induce disturbed fibrin turnover, secondary to enhanced procoagulant and antifibrinolytic activity during P. aeruginosa pneumosepsis, by a PAF/PAI-1-dependent mechanism.
Title: Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis.
PAI-1 is a critical mediator that controls the development of the early lung inflammation that is required for the activation of the later innate immune response necessary for the eradication of P aeruginosa from the distal airspaces of the lung.
Title: PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in mice.
the vitronectin-binding capacity of PAI-1 was the primary determinant required for its ability to exacerbate lung scarring induced by intratracheal bleomycin administration
Title: The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice.

Submit: New GeneRIF Correction See all (142)

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

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Function	Evidence Code	Pubs
protease binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
serine-type endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
cellular response to chemical stimulus	ISO Inferred from Sequence Orthology more info
cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
negative regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
negative regulation of fibrinolysis	ISO Inferred from Sequence Orthology more info
negative regulation of plasminogen activation	ISO Inferred from Sequence Orthology more info
negative regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
negative regulation of smooth muscle cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
negative regulation of vascular wound healing	ISO Inferred from Sequence Orthology more info
positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of blood coagulation	ISO Inferred from Sequence Orthology more info
positive regulation of coagulation	ISO Inferred from Sequence Orthology more info
positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
positive regulation of leukotriene production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
positive regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
regulation of receptor activity	ISO Inferred from Sequence Orthology more info
wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
extracellular matrix	ISO Inferred from Sequence Orthology more info
extracellular region	ISO Inferred from Sequence Orthology more info
extracellular space	IBA Inferred from Biological aspect of Ancestor more info
extracellular space	ISO Inferred from Sequence Orthology more info
soluble fraction	ISO Inferred from Sequence Orthology more info

General protein information

Preferred Names: plasminogen activator inhibitor 1

Names: plasminogen activator inhibitor 1; PAI; serpin E1; plasminogen activator inhibitor, type I; endothelial plasminogen activator inhibitor; nexin, plasminogen activator inhibitor type 1; serine (or cysteine) proteinase inhibitor, clade E, member 1; Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008871.2 → NP_032897.2 plasminogen activator inhibitor 1 precursor

Status: VALIDATED

Source sequence(s)

AC147986

Consensus CDS

CCDS19761.1

UniProtKB/TrEMBL

G5E899

Related

ENSMUSP00000039586, ENSMUST00000041388

Conserved Domains (2) summary

PHA02660
Location:54 – 402
Blast Score: 192

PHA02660; serpin-like protein; Provisional

cl00137
Location:29 – 402
Blast Score: 1305

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000071.6 Reference GRCm38 C57BL/6J

Range

137061504..137072272, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000027.1 Alternate Mm_Celera

Range

134078340..134089224, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC147986.3 (70385..81153)	None
genomic	CH466529.2	EDL19286.1	mixed
		EDL19287.1	mixed
genomic	M33961.1	None
mRNA	AK040662.1	None	C57BL/6J
mRNA	BC054091.1	AAH54091.1
mRNA	GQ872458.1	ACX48997.1	C57BL/6J
mRNA	GQ872459.1	ACX48998.1	A/J
mRNA	M33960.1	AAA39887.1