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Pkd2 polycystic kidney disease 2 [ Mus musculus (house mouse) ]

Gene ID: 18764, updated on 21-May-2016
Official Symbol
Pkd2provided by MGI
Official Full Name
polycystic kidney disease 2provided by MGI
Primary source
MGI:MGI:1099818
See related
Ensembl:ENSMUSG00000034462 Vega:OTTMUSG00000025951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PC2; TRPP2; C030034P18Rik
Orthologs
Location:
5 E5; 5 50.68 cM
Exon count:
15
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (104457224..104505819)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (104888476..104934838)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene matrix extracellular phosphoglycoprotein with ASARM motif (bone) Neighboring gene secreted phosphoprotein 1 Neighboring gene cDNA sequence BC005561 Neighboring gene RIKEN cDNA D930016D06 gene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
HLH domain binding ISO
Inferred from Sequence Orthology
more info
 
actinin binding ISO
Inferred from Sequence Orthology
more info
 
alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
 
calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium channel activity TAS
Traceable Author Statement
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-induced calcium release activity ISO
Inferred from Sequence Orthology
more info
 
channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
muscle alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
 
phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor binding ISO
Inferred from Sequence Orthology
more info
 
voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
voltage-gated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
voltage-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
voltage-gated sodium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
JAK-STAT cascade IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to fluid shear stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
cellular response to hydrostatic pressure ISO
Inferred from Sequence Orthology
more info
 
cellular response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic sequestering of transcription factor ISO
Inferred from Sequence Orthology
more info
 
detection of mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of nodal flow IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
determination of liver left/right asymmetry ISO
Inferred from Sequence Orthology
more info
 
embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart looping ISO
Inferred from Sequence Orthology
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
kidney development IGI
Inferred from Genetic Interaction
more info
PubMed 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
liver development IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ryanodine-sensitive calcium-release channel activity IDA
Inferred from Direct Assay
more info
PubMed 
placenta blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
regulation of cAMP metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
renal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
renal tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basal cortex IDA
Inferred from Direct Assay
more info
PubMed 
basal cortex ISO
Inferred from Sequence Orthology
more info
 
basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
cilium IDA
Inferred from Direct Assay
more info
PubMed 
cilium IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with filamentous actin ISO
Inferred from Sequence Orthology
more info
 
integral component of cytoplasmic side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of lumenal side of endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
motile primary cilium IDA
Inferred from Direct Assay
more info
PubMed 
nonmotile primary cilium IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
polycystin complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
polycystin-2
Names
polycystic kidney disease 2 protein homolog
polycystin 2
transient receptor potential cation channel subfamily P member 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008861.3NP_032887.3  polycystin-2

    See identical proteins and their annotated locations for NP_032887.3

    Status: VALIDATED

    Source sequence(s)
    AC123687, AK053502, AV517098, BU705556, CX566027
    Consensus CDS
    CCDS19487.1
    UniProtKB/Swiss-Prot
    O35245
    Related
    ENSMUSP00000084041, OTTMUSP00000031741, ENSMUST00000086831, OTTMUST00000064001
    Conserved Domains (2) summary
    pfam08016
    Location:265685
    PKD_channel; Polycystin cation channel
    cl08302
    Location:730776
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    104457224..104505819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534815.2XP_006534878.1  

    UniProtKB/Swiss-Prot
    O35245
    Conserved Domains (2) summary
    pfam08016
    Location:265629
    PKD_channel; Polycystin cation channel
    cl08302
    Location:674720
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RNA

  1. XR_389263.2 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    101769092..101817838
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)