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    E2F6 E2F transcription factor 6 [ Homo sapiens (human) ]

    Gene ID: 1876, updated on 5-May-2013
    Official Symbol
    E2F6provided by HGNC
    Official Full Name
    E2F transcription factor 6provided by HGNC
    Primary source
    HGNC:3120
    See related
    Ensembl:ENSG00000169016; HPRD:04251; MIM:602944; Vega:OTTHUMG00000090565
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E2F-6
    Summary
    This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms. [provided by RefSeq, Jul 2008]
    Location :
    2p25.1
    Sequence :
    Chromosome: 2; NC_000002.11 (11584501..11606297, complement)
    See E2F6 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis-trans isomerase A-like Neighboring gene long intergenic non-protein coding RNA 570 Neighboring gene microRNA 4429 Neighboring gene growth regulation by estrogen in breast cancer 1 Neighboring gene transfer RNA glycine 32 (anticodon CCC) pseudogene

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. E2F6 associates with BRG1 in transcriptional regulation. Leung JY, et al. PLoS One, 2012. PMID 23082233.
    2. PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Gao Z, et al. Mol Cell, 2012 Feb 10. PMID 22325352.
    3. Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK. Lin YY, et al. Nature, 2012 Feb 8. PMID 22318606.
    4. Toward an understanding of the protein interaction network of the human liver. Wang J, et al. Mol Syst Biol, 2011 Oct 11. PMID 21988832.
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.

    See all (39) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. E2F6 may recruit BRG1 in transcriptional regulation of genes important for G1/S phase transition of the cell cycle.
      Title: E2F6 associates with BRG1 in transcriptional regulation.
    2. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
    4. E2F6 has a role in control of hypoxia-induced apoptosis through regulation of E2F1
      Title: E2F6 inhibits cobalt chloride-mimetic hypoxia-induced apoptosis through E2F1.
    5. E2F6 binding sites are located within 2 kb of a transcription start site, in both normal and tumor cells
      Title: A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members.
    6. E2F-6 inhibited Apaf-1 upregulation by competing with E2F-1 for promoter binding. It enhanced the clonogenic growth of granulocyte, erythroid, macrophage, & megakaryocyte cells.It may prevent hematopoietic progenitor cell loss during proliferation.
      Title: E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1.
    7. results suggest that E2F6 represses transcription of the brca1, ctip, art27, hp1alpha, and the rbap48 genes and depletion of E2F6 resulted in the recruitment of E2F1 to the target promoters
      Title: E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9.
    8. showed that E2F6, DP1, EPC1, EZH2, and Sin3B co-elute, suggesting the identification of a novel E2F6 complex that exists in vivo in both normal and transformed human cell lines
      Title: A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a proliferation-specific manner.
    9. contains nine exons distributed along 20.4kbp of genomic DNA on chromosome 2 leading to the transcription of six alternatively spliced E2F6 mRNAs that encode four different E2F6 proteins
      Title: Human E2F6 is alternatively spliced to generate multiple protein isoforms.
    10. data suggest that E2F- and Myc-responsive genes are coregulated by E2F6 complex in quiescent cells
      Title: A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.
    Submit: New GeneRIF Correction See all (14)

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    E2F transcription factor 6 P35226 BMI1    HPRD  PubMed  
    E2F transcription factor 6 Q01094 E2F1    HPRD  PubMed  
    E2F transcription factor 6 Q9H2F5 EPC1    HPRD  PubMed  
    E2F transcription factor 6 Q15910 EZH2    HPRD  PubMed  
    E2F transcription factor 6 Q9BYE7 PCGF6    HPRD  PubMed  
    E2F transcription factor 6 Q06587 RING1    HPRD  PubMed  
    E2F transcription factor 6 Q8N488 RYBP    HPRD  PubMed  
    E2F transcription factor 6 Q14186 TFDP1    HPRD  PubMed  
    E2F transcription factor 6 Q14188 TFDP2    HPRD  PubMed  
    BioGRID:108208 BioGRID:106848 APP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108208 BioGRID:106864 ARAF    BioGRID  PubMed Two-hybrid 
    BioGRID:108208 BioGRID:107116 BMI1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108208 BioGRID:116463 CBX3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108208 BioGRID:108208 E2F6    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108208 BioGRID:114265 EED    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108208 BioGRID:123227 EPC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108208 BioGRID:108445 EZH1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108208 BioGRID:108446 EZH2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108208 BioGRID:199466 Epc1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108208 BioGRID:114368 HDAC3    BioGRID  PubMed Negative Genetic 
    BioGRID:108208 BioGRID:120968 HDAC8    BioGRID  PubMed Negative Genetic 
    BioGRID:108208 BioGRID:113870 KDM5C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108208 BioGRID:110443 KMT2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108208 BioGRID:113758 KMT2D    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108208 BioGRID:123753 L3MBTL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108208 BioGRID:123896 PCGF6    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108208 BioGRID:111947 RING1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108208 BioGRID:111972 RNF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108208 BioGRID:116997 RYBP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108208 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108208 BioGRID:112885 TFDP1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108208 BioGRID:112887 TFDP2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:108208 BioGRID:204138 Tfdp1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108208 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108208 BioGRID:115441 YAF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108208 BioGRID:115989 ZMYND11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108208 BioGRID:117146 ZMYND8    BioGRID  PubMed Affinity Capture-Western 
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC111545

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription corepressor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    negative regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription involved in G1/S phase of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    MLL1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    transcription factor E2F6
    Names
    transcription factor E2F6
    E2F transcription factor 6, isoform 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198256.2 → NP_937987.2  transcription factor E2F6

      Status: REVIEWED

      Source sequence(s)
      AC099344, AU142999, BC008348
      Consensus CDS
      CCDS1680.2
      UniProtKB/Swiss-Prot
      O75461
      Related
      ENSP00000370936, OTTHUMP00000115674, ENST00000381525, OTTHUMT00000207101
      Conserved Domains (1) summary
      pfam02319
      Location:63 – 128
      Blast Score: 252
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    RNA

    1. NR_003092.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC099344, AU142999, AY551347, BC008348

    2. NR_003093.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC099344, AU142999, BC008348, BU076470

    3. NR_003094.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC099344, AK096197, AU142999, BC008348

    4. NR_003095.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC099344, AU142999, BC008348, BI772069

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p10 Primary Assembly

      Range
      11584501..11606297, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      11434688..11456482, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018913.1 Alternate CHM1_1.0

      Range
      11555679..11577478, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198257.1: Suppressed sequence

      Description
      NM_198257.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_198258.1: Suppressed sequence

      Description
      NM_198258.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    3. NM_198325.1: Suppressed sequence

      Description
      NM_198325.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    4. NM_212540.1: Suppressed sequence

      Description
      NM_212540.1: This RefSeq was permanently suppressed because it contains the wrong CDS. If the CDS was correctly placed, it would be a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01015651.1 (3147..24941) None
    genomic AC099344.4 AAY14826.1
    genomic AJ493061.1 CAD37950.1
      CAD37951.1
      CAD37952.1
    genomic AMYH01010113.1 (99549..121348) None
    genomic AY083997.1 AAM10784.1
      AAM10785.1
    genomic AY551345.1 AAT02635.1
    genomic CH471053.2 EAX00931.1
      EAX00932.1
      EAX00933.1
      EAX00934.1
      EAX00935.1
      EAX00936.1
    mRNA AF041381.1 AAC14694.1
    mRNA AF059292.1 AAC31426.1
    mRNA AF088059.1 None
    mRNA AK096197.1 BAG53228.1
    mRNA AK223159.1 BAD96879.1
    mRNA AK223407.1 BAD97127.1
    mRNA AK290413.1 BAF83102.1
    mRNA AK293504.1 BAH11524.1
    mRNA AU132447.1 None
    mRNA AU142999.1 None
    mRNA AY083996.1 AAM10783.1
    mRNA AY551346.1 AAT02636.1
    mRNA AY551347.1 AAT02637.1
    mRNA AY551348.1 AAT02638.1
    mRNA AY551349.1 AAT02639.1
    mRNA AY551350.1 AAT02640.1
    mRNA AY551351.1 AAT02641.1
    mRNA BC008348.1 AAH08348.1
    mRNA BC062610.1 None
    mRNA BC107740.1 AAI07741.1
    mRNA BI772069.1 None
    mRNA BQ447956.1 None
    mRNA BU076470.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75461.1 GenPept UniProtKB/Swiss-Prot:O75461

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
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      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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