Format

Send to:

Choose Destination

Prkca protein kinase C, alpha [ Mus musculus (house mouse) ]

Gene ID: 18750, updated on 28-May-2016
Official Symbol
Prkcaprovided by MGI
Official Full Name
protein kinase C, alphaprovided by MGI
Primary source
MGI:MGI:97595
See related
Ensembl:ENSMUSG00000050965 Vega:OTTMUSG00000003131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pkca; AI875142
Orthologs
Location:
11 E1; 11 70.8 cM
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (107933387..108343888, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (107794701..108205202, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene calcium channel, voltage-dependent, gamma subunit 4 Neighboring gene calcium channel, voltage-dependent, gamma subunit 5 Neighboring gene microRNA 7223 Neighboring gene predicted gene, 36616 Neighboring gene predicted gene, 39432 Neighboring gene predicted gene, 36709 Neighboring gene apolipoprotein H

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
histone kinase activity (H3-T6 specific) ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to carbohydrate stimulus IDA
Inferred from Direct Assay
more info
PubMed 
central nervous system neuron axonogenesis ISO
Inferred from Sequence Orthology
more info
 
chondrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
desmosome assembly ISO
Inferred from Sequence Orthology
more info
 
histone H3-T6 phosphorylation ISO
Inferred from Sequence Orthology
more info
 
inactivation of MAPK activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
induction of positive chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning or memory ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of glial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glucose import IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of translation ISO
Inferred from Sequence Orthology
more info
 
neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dense core granule biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of platelet aggregation ISO
Inferred from Sequence Orthology
more info
 
regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of the force of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to estradiol ISO
Inferred from Sequence Orthology
more info
 
response to ethanol ISO
Inferred from Sequence Orthology
more info
 
response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
axon IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
protein kinase C alpha type
Names
PKC-A
PKC-alpha
protein kinase c-alpha
NP_035231.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011101.3NP_035231.2  protein kinase C alpha type

    See identical proteins and their annotated locations for NP_035231.2

    Status: VALIDATED

    Source sequence(s)
    AK147084, AL645535, BF455952
    Consensus CDS
    CCDS25573.1
    UniProtKB/Swiss-Prot
    P20444
    UniProtKB/TrEMBL
    Q4VA93
    Related
    ENSMUSP00000062392, OTTMUSP00000003037, ENSMUST00000059595, OTTMUST00000006450
    Conserved Domains (4) summary
    cd04026
    Location:159289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:339597
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:3786
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd05615
    Location:328668
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    107933387..108343888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    119670475..120082817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)