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Prkca protein kinase C, alpha [ Mus musculus (house mouse) ]

Gene ID: 18750, updated on 11-May-2013

Summary

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Official Symbol: Prkcaprovided by MGI
Official Full Name: protein kinase C, alphaprovided by MGI
Primary source: MGI:97595
Locus tag: RP23-145G23.2
See related: Ensembl:ENSMUSG00000050965; Vega:OTTMUSG00000003131
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pkca; AI875142

Genomic context

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Location :: 11 E1; 11 70.8 cM

Sequence :: Chromosome: 11; NC_000077.6 (107933387..108343888, complement)

See Prkca in Epigenomics, MapViewer

Chromosome 11 - NC_000077.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

This study aimed to investigate the functional and molecular changes of detrusor smooth muscle (DSM) in high-fat insulin resistant obese mice, focusing on the role of protein kinase C (PKC) and Ca(v)1.2 in causing bladder dysfunction.
Title: Role of PKC and CaV1.2 in detrusor overactivity in a model of obesity associated with insulin resistance in mice.
PKCalpha and Akt modulate platelet function by phosphorylating and inhibiting GSK3alpha/beta, thereby relieving the negative effect of GSK3alpha/beta on thrombin-mediated platelet activation.
Title: Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets.
The kinase PKCalpha selectively upregulates interleukin-17A during Th17 cell immune responses.
Title: The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses.
The elucidated signaling cascade explains how 5-HT(1A)-R regulates hippocampal sculpting and function, which may determine the affective phenotype of an adult.
Title: Serotonin 1A receptor-mediated signaling through ERK and PKCα is essential for normal synaptogenesis in neonatal mouse hippocampus.
It was concluded that PKCalpha mediates hypertonicity-stimulated urea transport but is not necessary for vasopressin stimulation of urea permeability in mouse inner medullary collecting ducts.
Title: Role of protein kinase C-α in hypertonicity-stimulated urea permeability in mouse inner medullary collecting ducts.
Follicle-stimulating hormone-induced activation of PKC alpha alone, or together with the inactivation of PKC betaI in granulosa cells, participates in mouse oocyte meiotic resumption.
Title: Specific protein kinase C isoforms α and βI are involved in follicle-stimulating hormone-induced mouse follicle-enclosed oocytes meiotic resumption.
Data show that PPARgamma regulates myogenic tone through downregulation of regulator of G protein signaling 5 (RGS5), which overactivating the protein kinase C (PKC) pathway and inhibition of the large conductance calcium-activated potassium channel (BKCa).
Title: PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity.
Src family kinases, PI3 kinase and protein kinase C synergize to mediate Gq-dependent platelet activation
Title: The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation.
PKC-alpha and PKC-delta are potentially involved in diabetes-promoted inflammation.
Title: High glucose increases nitric oxide generation in lipopolysaccharide-activated macrophages by enhancing activity of protein kinase C-α/δ and NF-κB.
TNF-alpha up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism
Title: TNF-α up-regulates protein level and cell surface expression of the leptin receptor by stimulating its export via a PKC-dependent mechanism.

Submit: New GeneRIF Correction See all (139)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (3) 1 citation
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_035231.1	AAD42950.2	Ldb3	BIND	PubMed	Cypher1 interacts with PKC-alpha. This interaction was modeled on a demonstrated interaction between mouse Cypher1 and rat PKC-alpha.
BioGRID:202194	BioGRID:198143	Apc	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:202194	BioGRID:198717	Cish	BioGRID	PubMed	Affinity Capture-Western
BioGRID:202194	BioGRID:206088	Fbxw7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:202194	BioGRID:200830	Itgb3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:202194	BioGRID:204912	Ldb3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:202194	BioGRID:229389	Pdlim2	BioGRID	PubMed	Biochemical Activity

Pathways from BioSystems

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African trypanosomiasis, organism-specific biosystem (from KEGG)
African trypanosomiasis, organism-specific biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
African trypanosomiasis, conserved biosystem (from KEGG)
African trypanosomiasis, conserved biosystemTrypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brai...
Aldosterone-regulated sodium reabsorption, organism-specific biosystem (from KEGG)
Aldosterone-regulated sodium reabsorption, organism-specific biosystemSodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-te...
Aldosterone-regulated sodium reabsorption, conserved biosystem (from KEGG)
Aldosterone-regulated sodium reabsorption, conserved biosystemSodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-te...
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystemIntegrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands...
Amoebiasis, organism-specific biosystem (from KEGG)
Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Amoebiasis, conserved biosystem (from KEGG)
Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
Amphetamine addiction, organism-specific biosystem (from KEGG)
Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
Amphetamine addiction, conserved biosystem (from KEGG)
Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
Ca-dependent events, organism-specific biosystem (from REACTOME)
Ca-dependent events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CaM pathway, organism-specific biosystem (from REACTOME)
CaM pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
Calcium signaling pathway, organism-specific biosystem (from KEGG)
Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
Calcium signaling pathway, conserved biosystem (from KEGG)
Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
Calmodulin induced events, organism-specific biosystem (from REACTOME)
Calmodulin induced events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cholinergic synapse, organism-specific biosystem (from KEGG)
Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
Circadian entrainment, organism-specific biosystem (from KEGG)
Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
Circadian entrainment, conserved biosystem (from KEGG)
Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
DAG and IP3 signaling, organism-specific biosystem (from REACTOME)
DAG and IP3 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 interactions, organism-specific biosystem (from REACTOME)
DAP12 interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 signaling, organism-specific biosystem (from REACTOME)
DAP12 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Disinhibition of SNARE formation, organism-specific biosystem (from REACTOME)
Disinhibition of SNARE formation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dopaminergic synapse, organism-specific biosystem (from KEGG)
Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
Dopaminergic synapse, conserved biosystem (from KEGG)
Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
Downstream signal transduction, organism-specific biosystem (from REACTOME)
Downstream signal transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR Transactivation by Gastrin, organism-specific biosystem (from REACTOME)
EGFR Transactivation by Gastrin, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR interacts with phospholipase C-gamma, organism-specific biosystem (from REACTOME)
EGFR interacts with phospholipase C-gamma, organism-specific biosystemcomputationally inferred pathway (not manually curated)
EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem (from KEGG)
Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
Endocrine and other factor-regulated calcium reabsorption, conserved biosystem (from KEGG)
Endocrine and other factor-regulated calcium reabsorption, conserved biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
ErbB signaling pathway, organism-specific biosystem (from KEGG)
ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
ErbB signaling pathway, conserved biosystem (from KEGG)
ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
Fc epsilon RI signaling pathway, organism-specific biosystem (from KEGG)
Fc epsilon RI signaling pathway, organism-specific biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
Focal adhesion, organism-specific biosystem (from KEGG)
Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, conserved biosystem (from KEGG)
Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
G alpha (z) signalling events, organism-specific biosystem (from REACTOME)
G alpha (z) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
G-protein mediated events, organism-specific biosystem (from REACTOME)
G-protein mediated events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
GABAergic synapse, organism-specific biosystem (from KEGG)
GABAergic synapse, organism-specific biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
GABAergic synapse, conserved biosystem (from KEGG)
GABAergic synapse, conserved biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gap junction, organism-specific biosystem (from KEGG)
Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Gap junction, conserved biosystem (from KEGG)
Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Gastric acid secretion, organism-specific biosystem (from KEGG)
Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
Gastric acid secretion, conserved biosystem (from KEGG)
Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glioma, organism-specific biosystem (from KEGG)
Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
Glioma, conserved biosystem (from KEGG)
Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem (from REACTOME)
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Glutamatergic synapse, organism-specific biosystem (from KEGG)
Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
Glutamatergic synapse, conserved biosystem (from KEGG)
Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
GnRH signaling pathway, organism-specific biosystem (from KEGG)
GnRH signaling pathway, organism-specific biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
GnRH signaling pathway, conserved biosystem (from KEGG)
GnRH signaling pathway, conserved biosystemGonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnR...
HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hepatitis B, organism-specific biosystem (from KEGG)
Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
IL-3 Signaling Pathway, organism-specific biosystem (from WikiPathways)
IL-3 Signaling Pathway, organism-specific biosystemInterleukin-3 belongs to a family of cytokines, which includes IL-5 and GM-CSF. It signals through a receptor complex comprising of an IL-3 specific IL-3 receptor alpha subunit (IL3RA) and a common b...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Influenza A, organism-specific biosystem (from KEGG)
Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Influenza A, conserved biosystem (from KEGG)
Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Insulin Signaling, organism-specific biosystem (from WikiPathways)
Insulin Signaling, organism-specific biosystem
Insulin Signaling
Insulin secretion, organism-specific biosystem (from KEGG)
Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
Integration of energy metabolism, organism-specific biosystem (from REACTOME)
Integration of energy metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Keap1-Nrf2, organism-specific biosystem (from WikiPathways)
Keap1-Nrf2, organism-specific biosystemBased on [http://www.nature.com/nrc/journal/v3/n10/fig_tab/nrc1189_F4.html Surh, 2003, figure 4].
Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
Leukocyte transendothelial migration, organism-specific biosystem (from KEGG)
Leukocyte transendothelial migration, organism-specific biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
Leukocyte transendothelial migration, conserved biosystem (from KEGG)
Leukocyte transendothelial migration, conserved biosystemLeukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (C...
Long-term depression, organism-specific biosystem (from KEGG)
Long-term depression, organism-specific biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
Long-term depression, conserved biosystem (from KEGG)
Long-term depression, conserved biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
Long-term potentiation, organism-specific biosystem (from KEGG)
Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
Long-term potentiation, conserved biosystem (from KEGG)
Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
Melanogenesis, organism-specific biosystem (from KEGG)
Melanogenesis, organism-specific biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
Melanogenesis, conserved biosystem (from KEGG)
Melanogenesis, conserved biosystemCutaneous melanin pigment plays a critical role in camouflage, mimicry, social communication, and protection against harmful effects of solar radiation. Melanogenesis is under complex regulatory cont...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Morphine addiction, organism-specific biosystem (from KEGG)
Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
Morphine addiction, conserved biosystem (from KEGG)
Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
Myometrial Relaxation and Contraction Pathways, organism-specific biosystem
Myometrial Relaxation and Contraction Pathways
NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
Neuronal System, organism-specific biosystem (from REACTOME)
Neuronal System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Non-small cell lung cancer, organism-specific biosystem (from KEGG)
Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
Non-small cell lung cancer, conserved biosystem (from KEGG)
Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
Opioid Signalling, organism-specific biosystem (from REACTOME)
Opioid Signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PLC beta mediated events, organism-specific biosystem (from REACTOME)
PLC beta mediated events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PLC-gamma1 signalling, organism-specific biosystem (from REACTOME)
PLC-gamma1 signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PLCG1 events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
PLCG1 events in ERBB2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pancreatic secretion, organism-specific biosystem (from KEGG)
Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
Pancreatic secretion, conserved biosystem (from KEGG)
Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Phosphatidylinositol signaling system, organism-specific biosystem (from KEGG)
Phosphatidylinositol signaling system, organism-specific biosystem
Phosphatidylinositol signaling system
Phosphatidylinositol signaling system, conserved biosystem (from KEGG)
Phosphatidylinositol signaling system, conserved biosystem
Phosphatidylinositol signaling system
Phospholipase C-mediated cascade, organism-specific biosystem (from REACTOME)
Phospholipase C-mediated cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystem (from WikiPathways)
PodNet: protein-protein interactions in the podocyte, organism-specific biosystemPodNet is a manually curated network of protein-protein interactions occurring in the podocyte.
Proteoglycans in cancer, organism-specific biosystem (from KEGG)
Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Proteoglycans in cancer, conserved biosystem (from KEGG)
Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Regulation of Insulin Secretion, organism-specific biosystem (from REACTOME)
Regulation of Insulin Secretion, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of Insulin Secretion by Acetylcholine, organism-specific biosystem (from REACTOME)
Regulation of Insulin Secretion by Acetylcholine, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of KIT signaling, organism-specific biosystem (from REACTOME)
Regulation of KIT signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements, organism-specific biosystem (from REACTOME)
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
Salivary secretion, organism-specific biosystem (from KEGG)
Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
Salivary secretion, conserved biosystem (from KEGG)
Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
Serotonergic synapse, organism-specific biosystem (from KEGG)
Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR, organism-specific biosystem (from REACTOME)
Signaling by EGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
Signaling by EGFR in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB2, organism-specific biosystem (from REACTOME)
Signaling by ERBB2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR, organism-specific biosystem (from REACTOME)
Signaling by FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
Signaling by FGFR in disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by PDGF, organism-specific biosystem (from REACTOME)
Signaling by PDGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
Signaling by SCF-KIT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
Stabilization of mRNA by HuR, organism-specific biosystem (from REACTOME)
Stabilization of mRNA by HuR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Tight junction, organism-specific biosystem (from KEGG)
Tight junction, organism-specific biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
Tight junction, conserved biosystem (from KEGG)
Tight junction, conserved biosystemEpithelial tight junctions (TJs) are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of ma...
Trafficking of AMPA receptors, organism-specific biosystem (from REACTOME)
Trafficking of AMPA receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Trafficking of GluR2-containing AMPA receptors, organism-specific biosystem (from REACTOME)
Trafficking of GluR2-containing AMPA receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
Transmission across Chemical Synapses, organism-specific biosystemcomputationally inferred pathway (not manually curated)
VEGF signaling pathway, organism-specific biosystem (from KEGG)
VEGF signaling pathway, organism-specific biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
VEGF signaling pathway, conserved biosystem (from KEGG)
VEGF signaling pathway, conserved biosystemThere is now much evidence that VEGFR-2 is the major mediator of VEGF-driven responses in endothelial cells and it is considered to be a crucial signal transducer in both physiologic and pathologic a...
Vascular smooth muscle contraction, organism-specific biosystem (from KEGG)
Vascular smooth muscle contraction, organism-specific biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
Vascular smooth muscle contraction, conserved biosystem (from KEGG)
Vascular smooth muscle contraction, conserved biosystemThe vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regula...
Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell pluri...
Wnt signaling pathway, organism-specific biosystem (from KEGG)
Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt signaling pathway, conserved biosystem (from KEGG)
Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
mTOR signaling pathway, organism-specific biosystem (from KEGG)
mTOR signaling pathway, organism-specific biosystem
mTOR signaling pathway
mTOR signaling pathway, conserved biosystem (from KEGG)
mTOR signaling pathway, conserved biosystem
mTOR signaling pathway

General gene information

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Markers

Prkca (e-PCR), detects polymorphism
- UniSTS:507177

Prkca (e-PCR), detects polymorphism
- UniSTS:144191

Prkca (e-PCR), detects polymorphism
- UniSTS:144192

Prkca (e-PCR), detects polymorphism
- UniSTS:144193

Prkca (e-PCR), detects polymorphism
- UniSTS:239205

Prkca (e-PCR), detects polymorphism
- UniSTS:239206

Prkca (e-PCR), detects polymorphism
- UniSTS:239207

AI875142 (e-PCR)
- UniSTS:165806

Homology

Homologs of the Prkca gene: The Prkca gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, and mosquito.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
calcium-dependent protein kinase C activity	IDA Inferred from Direct Assay more info	PubMed
calcium-dependent protein kinase C activity	ISO Inferred from Sequence Orthology more info
enzyme binding	ISO Inferred from Sequence Orthology more info
histone kinase activity (H3-T6 specific)	ISO Inferred from Sequence Orthology more info
kinase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase C activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase C activity	ISO Inferred from Sequence Orthology more info
protein kinase activity	ISO Inferred from Sequence Orthology more info
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
angiogenesis	IEA Inferred from Electronic Annotation more info
apoptotic process	IEA Inferred from Electronic Annotation more info
cell adhesion	IEA Inferred from Electronic Annotation more info
cellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
cellular response to carbohydrate stimulus	IDA Inferred from Direct Assay more info	PubMed
central nervous system neuron axonogenesis	ISO Inferred from Sequence Orthology more info
chondrocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
desmosome assembly	ISO Inferred from Sequence Orthology more info
histone H3-T6 phosphorylation	ISO Inferred from Sequence Orthology more info
inactivation of MAPK activity	IMP Inferred from Mutant Phenotype more info	PubMed
induction of positive chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
intracellular signal transduction	ISO Inferred from Sequence Orthology more info
intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
learning or memory	ISO Inferred from Sequence Orthology more info
negative regulation of cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of glial cell apoptotic process	ISO Inferred from Sequence Orthology more info
negative regulation of glucose import	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of heart contraction	ISO Inferred from Sequence Orthology more info
negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of translation	ISO Inferred from Sequence Orthology more info
neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of cardiac muscle hypertrophy	ISO Inferred from Sequence Orthology more info
positive regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
positive regulation of dense core granule biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of exocytosis	ISO Inferred from Sequence Orthology more info
positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of lipopolysaccharide-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
protein autophosphorylation	ISO Inferred from Sequence Orthology more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	ISO Inferred from Sequence Orthology more info
regulation of muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of platelet aggregation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of platelet aggregation	ISO Inferred from Sequence Orthology more info
regulation of receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
regulation of the force of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
response to estradiol stimulus	ISO Inferred from Sequence Orthology more info
response to ethanol	ISO Inferred from Sequence Orthology more info
response to interleukin-1	ISO Inferred from Sequence Orthology more info
response to reactive oxygen species	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	ISO Inferred from Sequence Orthology more info
cytosol	ISO Inferred from Sequence Orthology more info
dendrite	IDA Inferred from Direct Assay more info	PubMed
endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
membrane raft	ISO Inferred from Sequence Orthology more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	ISO Inferred from Sequence Orthology more info
neuron projection	ISO Inferred from Sequence Orthology more info
neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	ISO Inferred from Sequence Orthology more info
protein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein kinase C alpha type

Names: protein kinase C alpha type; PKC-A; PKC-alpha; protein kinase c-alpha

NP_035231.2

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011101.3 → NP_035231.2 protein kinase C alpha type

Status: VALIDATED

Source sequence(s)

AK147084, AL645535, BF455952

Consensus CDS

CCDS25573.1

UniProtKB/Swiss-Prot

P20444

UniProtKB/TrEMBL

Q4VA93

Related

ENSMUSP00000062392, OTTMUSP00000003037, ENSMUST00000059595, OTTMUST00000006450

Conserved Domains (4) summary

cd00029
Location:37 – 86
Blast Score: 177

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd05587
Location:338 – 660
Blast Score: 1835

STKc_cPKC; Catalytic domain of the Protein Serine/Threonine Kinase, Classical Protein Kinase C

cd04026
Location:159 – 289
Blast Score: 745

C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma

smart00220
Location:339 – 597
Blast Score: 748

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000077.6 Reference GRCm38.p1 C57BL/6J

Range

107933387..108343888, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000033.1 Alternate Mm_Celera

Range

119670475..120082817, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01096135.1 (4550..17855)	None
genomic	AAHY01096136.1	None
genomic	AAHY01096137.1	None
genomic	AAHY01096138.1	None
genomic	AAHY01096139.1	None
genomic	AAHY01096140.1	None
genomic	AAHY01096141.1	None
genomic	AAHY01096142.1	None
genomic	AAHY01096143.1	None
genomic	AAHY01096144.1	None
genomic	AAHY01096145.1	None
genomic	AAHY01096146.1	None
genomic	AAHY01096147.1	None
genomic	AAHY01096148.1	None
genomic	AAHY01096149.1	None
genomic	AAHY01096150.1	None
genomic	AAHY01096151.1	None
genomic	AAHY01096152.1	None
genomic	AAHY01096153.1	None
genomic	AAHY01096154.1	None
genomic	AAHY01096155.1	None
genomic	AAHY01096156.1	None
genomic	AAHY01096157.1	None
genomic	AAHY01096158.1	None
genomic	AAHY01096159.1	None
genomic	AAHY01096160.1	None
genomic	AAHY01096161.1	None
genomic	AAHY01096162.1	None
genomic	AAHY01096163.1	None
genomic	AAHY01096164.1	None
genomic	AAHY01096165.1	None
genomic	AAHY01096166.1	None
genomic	AAHY01096167.1	None
genomic	AAHY01096168.1	None
genomic	AAHY01096169.1	None
genomic	AAHY01096170.1	None
genomic	AAHY01096171.1 (10515..31261)	None
genomic	AF178928.1	AAD51851.1	129/SvJ
genomic	AL607041.18 (2000..158104)	None	ZRU
genomic	AL645535.16 (81120..161362)	None
genomic	AL645963.9 (2000..176153)	None	ZRU
genomic	CH466558.1	EDL34340.1	mixed
mRNA	AK047652.1	None	C57BL/6J
mRNA	AK079091.1	None	C57BL/6J
mRNA	AK147084.1	BAE27664.1	C57BL/6J
mRNA	AK163950.1	BAE37546.1	C57BL/6J
mRNA	BC096493.1	AAH96493.1	C3H/He
mRNA	BF455952.1	None	C57BL/6J
mRNA	M25811.1	AAA39934.1	Swiss
mRNA	X52684.1	CAA36907.1
mRNA	X52685.1	CAA36908.1	BALB/c