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    E2F4 E2F transcription factor 4, p107/p130-binding [ Homo sapiens ]

    Gene ID: 1874, updated on 11-May-2012
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    Summary

    Official Symbol
    E2F4provided by HGNC
    Official Full Name
    E2F transcription factor 4, p107/p130-bindingprovided by HGNC
    Primary source
    HGNC:3118
    See related
    Ensembl:ENSG00000205250; HPRD:02806; MIM:600659; Vega:OTTHUMG00000172975
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E2F-4
    Summary
    The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    16q21-q22
    Sequence :
    Chromosome: 16; NC_000016.9 (67226068..67232821)
    See E2F4 in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene nucleolar protein 3 (apoptosis repressor with CARD domain) Neighboring gene KIAA0895-like Neighboring gene exocyst complex component 3-like 1 Neighboring gene engulfment and cell motility 3 Neighboring gene microRNA 328 Neighboring gene leucine rich repeat containing 29

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors. Huang L, et al. PLoS One, 2011. PMID 21789246.
    3. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. Lettre G, et al. PLoS Genet, 2011 Feb 10. PMID 21347282.
    4. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. Casabonne D, et al. Haematologica, 2011 Feb. PMID 21048031.
    5. Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark. Revenko AS, et al. Mol Cell Biol, 2010 Nov. PMID 20855524.

    See all (87) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Tamoxifen resistant tumors displayed enriched expression of genes related to cell cycle and proliferation, as well as elevated activity of E2F transcription factors.
      Title: An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors.
    2. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
    3. There were no significant changes of CDK4 and E2F-1/4 expression in benzo(a)pyrene treated embryo lung fibroblasts.
      Title: [Benzo(a)pyrene induced changes of cyclin D1, CDK4 and E2F-1/4 expression in human embryo lung fibroblasts].
    4. Our data indicate that E2F4 is required for cardiomyocyte proliferation and suggest a function for E2F4 in mitosis
      Title: E2F4 is required for cardiomyocyte proliferation.
    5. E2F4, PHACTR3, PRAME family member and CDH12 most probably play important role in non-small-cell lung cancer geneses
      Title: Identification of genes associated with non-small-cell lung cancer promotion and progression.
    6. E2F4 may be determinant in the promotion of proliferation of human intestinal epithelial crypt cells and colorectal cancer cells.
      Title: E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells.
    7. FBI-1 is the first transcriptional repressor shown to act as a dual regulator in adipogenesis exerting repressor activities on target genes by both, direct and indirect mechanisms.
      Title: Transcription factor FBI-1 acts as a dual regulator in adipogenesis by coordinated regulation of cyclin-A and E2F-4.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
    9. Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor
      Title: Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor.
    10. E2F4, binding sites are located within 2 kb of a transcription start site, in both normal and tumor cells
      Title: A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members.
    Submit: New GeneRIF Correction See all (25)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat Binding of HIV-1 Tat to E2F4 is mediated through amino acids 1-49 of Tat and 1-184 of E2F4, allowing Tat to recruit E2F4 to promoter elements to exert its multiple biological activities PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001941.2 NC_000022.8 ACR    BIND  PubMed E2F4 interacts with ACR promoter. 
    NP_001941.2 NC_000015.8 ARHGAP11A    BIND  PubMed E2F4 interacts with ARHGAP11A promoter. 
    NP_001941.2 NC_000002.9 BARD1    BIND  PubMed E2F4 interacts with the BARD1 promoter region. 
    NP_001941.2 U75285.1 BIRC5    BIND  PubMed E2F4 (E2F-4) interacts with the BIRC5 (survivin) promoter. 
    NP_001941.2 NP_009227.1 BRCA1    BIND  PubMed BRCA1 associates with E2F-4 
    NP_001941.2 NC_000010.8 BTRC    BIND  PubMed E2F4 interacts with BTRC promoter. 
    NP_001941.2 NC_000021.7 C21orf32    BIND  PubMed E2F4 interacts with C21orf32 promoter. 
    NP_001941.2 NC_000012.9 CBX5    BIND  PubMed E2F4 interacts with the HP1-alpha chromatin. 
    NP_001941.2 NC_000001.8 CCDC76    BIND  PubMed E2F4 interacts with the FLJ10287 chromatin. 
    NP_001941.2 NC_000004.9 CCNA2    BIND  PubMed E2F4 interacts with the Cyclin A promoter region. 
    NP_001941.2 NC_000004.9 CCNA2    BIND  PubMed E2F4 interacts with CCNA2 promoter. 
    NP_001941.2 NC_000003.9 CDC25A    BIND  PubMed E2F4 interacts with the Cdc25A promoter region. 
    NP_001941.2 NC_000017.9 CDC6    BIND  PubMed E2F4 interacts with the Cdc6 promoter region. 
    NP_001941.2 NC_000010.8 CDK1    BIND  PubMed E2F4 interacts with CDC2 promoter. 
    NP_001941.2 NC_000010.8 CDK1    BIND  PubMed E2F4 interacts with the Cdc2 promoter. 
    NP_001941.2 NC_000010.8 CDK1    BIND  PubMed E2F4 interacts with the CDC2 promoter. 
    NP_001941.2 NC_000011.8 CHEK1    BIND  PubMed E2F4 interacts with the Chk1 promoter region. 
    NP_001941.2 NC_000012.9 CSDA    BIND  PubMed E2F4 interacts with the DBPA chromatin. 
    NP_001941.2 NC_000011.8 CSTF3    BIND  PubMed E2F4 interacts with CSTF3 promoter. 
    NP_001941.2 NC_000012.9 CYP27B1    BIND  PubMed E2F4 interacts, albeit weakly, with the CYP27B1 chromatin. 
    NP_001941.2 NC_000017.9 DBF4B    BIND  PubMed E2F4 interacts with DRF1 promoter. 
    NP_001941.2 NC_000020.9 E2F1    BIND  PubMed E2F4 interacts with the E2F1 promoter region. 
    NP_001941.2 NC_000001.8 E2F2    BIND  PubMed E2F4 interacts with the E2F2 promoter. 
    NP_001941.2 FHL2    BIND  PubMed E2F4 interacts with a molecule expressed by Gene FHL2. The precise molecular variant of FHL2 involved in this interaction is not specified. 
    NP_001941.2 NC_000007.11 FLJ20712    BIND  PubMed E2F4 interacts with FLJ20712 promoter. 
    NP_001941.2 NC_000022.8 GAS2L1    BIND  PubMed E2F4 interacts with the GAR22 chromatin. 
    NP_001941.2 NC_000006.9 HIST1H2AG    BIND  PubMed E2F4 interacts with the H2A chromatin. 
    NP_001941.2 NC_000006.9 HIST1H2BJ    BIND  PubMed E2F4 interacts with the H2B chromatin. 
    NP_001941.2 NC_000001.8 HIST2H4A    BIND  PubMed E2F4 interacts with the H4F2 chromatin. 
    NP_001941.2 NC_000007.11 HOXA3    BIND  PubMed E2F4 interacts with HOXA3 promoter. 
    NP_001941.2 NC_000005.8 JMY    BIND  PubMed E2F4 interacts with the JMY promoter. 
    NP_001941.2 NC_000020.9 JPH2    BIND  PubMed E2F4 interacts with JPH2 promoter. 
    NP_001941.2 NC_000013.9 LMO7    BIND  PubMed E2F4 interacts with LMO7 promoter. 
    NP_001941.2 NC_000004.9 MAD2L1    BIND  PubMed E2F4 interacts with the MAD2 promoter region. 
    NP_001941.2 NC_000006.9 MAP3K7    BIND  PubMed E2F4 interacts with MAP3K7 promoter. 
    NP_001941.2 NC_000012.9 METAP2    BIND  PubMed E2F4 interacts with METAP2 promoter. 
    NP_001941.2 NC_000015.8 MFAP1    BIND  PubMed E2F4 interacts with the MFAP1 chromatin. 
    NP_001941.2 NC_000019.8 MGC45922    BIND  PubMed E2F4 interacts with MGC45922 promoter. 
    NP_001941.2 NC_000003.9 MLH1    BIND  PubMed E2F4 interacts with the MLH1 promoter region. 
    NP_001941.2 NC_000002.9 MSH2    BIND  PubMed E2F4 interacts with the MSH2 promoter. 
    NP_001941.2 J03910.1 MT1G    BIND  PubMed E2F4 interacts with the MT1G promoter. 
    NP_001941.2 NC_000020.9 MYBL2    BIND  PubMed E2F4 interacts with the B-myb promoter region. 
    NP_001941.2 AY214166.1 MYC    BIND  PubMed E2F-4 interacts with the MYC gene P2 promoter region. 
    NP_001941.2 NC_000008.9 PBK    BIND  PubMed E2F4 interacts with TOPK promoter. 
    NP_001941.2 NC_000007.11 PPIA    BIND  PubMed E2F4 interacts with PPIA enhancer. 
    NP_001941.2 NC_000014.7 PPP1R13B    BIND  PubMed E2F4 interacts with the PPP1R13B (ASPP1) promoter. 
    NP_001941.2 NC_000017.9 PRR11    BIND  PubMed E2F4 interacts with the FLJ11029 chromatin. 
    NP_001941.2 NC_000015.8 PSMA4    BIND  PubMed E2F4 interacts with PSMA4 promoter. 
    NP_001941.2 NC_000019.8 QPCTL    BIND  PubMed E2F4 interacts with QPCTL promoter. 
    NP_001941.2 NC_000015.8 RAD51    BIND  PubMed E2F4 interacts with the RAD51 chromatin. 
    NP_001941.2 NC_000001.8 RAD54L    BIND  PubMed E2F4 interacts with the RAD54 promoter region. 
    NP_001941.2 NC_000001.8 RAD54L    BIND  PubMed E2F4 interacts with RAD54L promoter. 
    NP_001941.2 NC_000020.9 RBL1    BIND  PubMed E2F4 interacts with the p107 promoter region. 
    NP_001941.2 NP_002886.2 RBL1    BIND  PubMed p107 interacts with E2F4. 
    NP_001941.2 NP_005602.2 RBL2    BIND  PubMed E2F-4 interacts with p130. 
    NP_001941.2 NC_000012.9 RECQL    BIND  PubMed E2F4 interacts with the RECQL chromatin. 
    NP_001941.2 NC_000011.8 SLC3A2    BIND  PubMed E2F4 interacts with SLC3A2 promoter. 
    NP_001941.2 NC_000019.8 SNRPD2    BIND  PubMed E2F4 interacts with SNRPD2 promoter. 
    NP_001941.2 NC_000012.9 SOAT2    BIND  PubMed E2F4 interacts with SOAT2 promoter. 
    NP_001941.2 NC_000020.9 SRC    BIND  PubMed E2F4 interacts with SRC enhancer. 
    NP_001941.2 NP_009042.1 TFDP1    BIND  PubMed E2F-4 interacts with DP-1. 
    NP_001941.2 NC_000017.9 TOP2A    BIND  PubMed E2F4 interacts with the TopoII promoter region. 
    NP_001941.2 NC_000001.8 TP53BP2    BIND  PubMed E2F4 interacts with the TP53BP2 (ASPP2) promoter. 
    NP_001941.2 NC_000008.9 TP53INP1    BIND  PubMed E2F4 interacts with the TP53INP1 promoter. 
    NP_001941.2 NC_000008.9 TRIM55    BIND  PubMed E2F4 interacts with RNF29 promoter. 
    NP_001941.2 NC_000006.9 TTK    BIND  PubMed E2F4 interacts with the TTK chromatin. 
    NP_001941.2 NC_000018.8 TYMS    BIND  PubMed E2F4 interacts with the TYMS chromatin. 
    NP_001941.2 NC_000023.8 UXT    BIND  PubMed E2F4 interacts with the UXT chromatin. 
    NP_001941.2 NP_057853.1 tat    BIND  PubMed Tat interacts with E2F-4. 
    NP_001941.2 Z55309.1     BIND  PubMed E2F4 interacts with the CpG32C1 chromatin. 
    NP_001941.2 Z56578.1     BIND  PubMed E2F4 interacts with the CpG12B10 chromatin. 
    NP_001941.2 Z57695.1     BIND  PubMed E2F4 interacts with the CpG18G8 chromatin. 
    Q16254 Q99856 ARID3A    HPRD  PubMed  
    Q16254 P38398 BRCA1    HPRD  PubMed  
    Q16254 Q99608 NDN    HPRD  PubMed  
    Q16254 Q14978 NOLC1    HPRD  PubMed  
    Q16254 P06400 RB1    HPRD  PubMed  
    Q16254 P28749 RBL1    HPRD  PubMed  
    Q16254 Q08999 RBL2    HPRD  PubMed  
    Q16254 Q15796 SMAD2    HPRD  PubMed  
    Q16254 P84022 SMAD3    HPRD  PubMed  
    Q16254 Q14186 TFDP1    HPRD  PubMed  
    Q16254 Q14188 TFDP2    HPRD  PubMed  
    Q16254 Q9Y4A5 TRRAP    HPRD  PubMed  
    BioGRID:108206 BioGRID:114528 ASH2L    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108206 BioGRID:118827 ATAD2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108206 BioGRID:107140 BRCA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108206 BioGRID:107338 CCNE1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108206 BioGRID:108201 E2F1    BioGRID  PubMed Co-localization 
    BioGRID:108206 BioGRID:108565 FHL2    BioGRID  PubMed Two-hybrid 
    BioGRID:108206 BioGRID:109304 HCFC1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108206 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108206 BioGRID:109624 ID2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108206 BioGRID:109625 ID3    BioGRID  PubMed Two-hybrid 
    BioGRID:108206 BioGRID:108918 KAT2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108206 BioGRID:121008 LIN37    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108206 BioGRID:126328 LIN54    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108206 BioGRID:130420 LIN9    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108206 BioGRID:116870 MGA    BioGRID  PubMed Two-hybrid 
    BioGRID:108206 BioGRID:110443 MLL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108206 BioGRID:201712 Ndn    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex 
    BioGRID:108206 BioGRID:111860 RB1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108206 BioGRID:111868 RBL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108206 BioGRID:111869 RBL2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:108206 BioGRID:115125 RNF144A    BioGRID  PubMed Two-hybrid 
    BioGRID:108206 BioGRID:116997 RYBP    BioGRID  PubMed Two-hybrid 
    BioGRID:108206 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108206 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108206 BioGRID:112567 SPIB    BioGRID  PubMed Two-hybrid 
    BioGRID:108206 BioGRID:112885 TFDP1    BioGRID  PubMed Two-hybrid 
    BioGRID:108206 BioGRID:112887 TFDP2    BioGRID  PubMed Co-crystal Structure 
    BioGRID:108206 BioGRID:113900 TRRAP    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108206 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adipogenesis, organism-specific biosystem (from WikiPathways)
      Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
      Cyclin D associated events in G1, organism-specific biosystemThree D-type cyclins are essential for progression from G1 to S-phase. These D cyclins bind to and activate both CDK4 and CDK6. The formation of all possible complexes between the D-type cyclins and...
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • G0 and Early G1, organism-specific biosystem (from REACTOME)
      G0 and Early G1, organism-specific biosystemIn G0 and early G1 in quiescent cells, p130 (RBL2) bound to E2F4 or E2F5 and either DP1 or DP2, associates with the MuvB complex, forming an evolutionarily conserved DREAM complex, that represses tra...
    • G1 Phase, organism-specific biosystem (from REACTOME)
      G1 Phase, organism-specific biosystemEarly cell cycle progression in G1 is under the control of the D-type cyclins together with Cdk4 and Cdk6. An important target for these CDKs is the Retinoblastoma (Rb) protein, which when phosphoryl...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of retinoblastoma protein, organism-specific biosystem
      Regulation of retinoblastoma protein
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
      TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TGF-beta signaling pathway, conserved biosystem (from KEGG)
      TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G1 phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    blood circulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell volume homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    epithelial cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    organ morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription involved in G1/S phase of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    transcription factor E2F4
    Names
    transcription factor E2F4
    p107/p130-binding protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001950.3 → NP_001941.2  transcription factor E2F4

      Status: REVIEWED

      Source sequence(s)
      BC021050, BU857680
      Consensus CDS
      CCDS32464.1
      UniProtKB/Swiss-Prot
      Q16254
      Related
      ENSP00000368686, OTTHUMP00000249833, ENST00000379378, OTTHUMT00000421565
      Conserved Domains (1) summary
      pfam02319
      Location:17 – 83
      Blast Score: 322
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      67226068..67232821
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      53099244..53105997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC040160.4 (139906..146659) None
    genomic AF250378.1 AAF65226.1
    genomic AF527540.1 AAM77918.1
    genomic CH471092.1 EAW83094.1
      EAW83095.1
      EAW83096.1
    genomic HI179032.1 CBX53825.1
    mRNA AB451292.1 BAG70106.1
    mRNA AB451425.1 BAG70239.1
    mRNA BC021050.1 None
    mRNA BC031071.1 None
    mRNA BC033180.1 AAH33180.1
    mRNA BU857680.1 None
    mRNA S75174.1 AAB32597.1
    mRNA U15641.1 AAC50119.1
    mRNA X86096.1 CAA60050.2
    other-genetic DQ892803.2 ABM83729.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q16254.2 GenPept UniProtKB/Swiss-Prot:Q16254
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