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Pim2 proviral integration site 2 [ Mus musculus (house mouse) ]

Gene ID: 18715, updated on 28-May-2016
Official Symbol
Pim2provided by MGI
Official Full Name
proviral integration site 2provided by MGI
Primary source
MGI:MGI:97587
See related
Ensembl:ENSMUSG00000031155 Vega:OTTMUSG00000018000
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pim-2; DXCch3
Orthologs
Location:
X A1.1; X 3.55 cM
Exon count:
6
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) X NC_000086.7 (7878306..7883432)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (7455432..7460558)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, Shal-related family, member 1 Neighboring gene OTU domain containing 5 Neighboring gene solute carrier family 35 (UDP-galactose transporter), member A2 Neighboring gene polyglutamine binding protein 1 Neighboring gene translocase of inner mitochondrial membrane 17b

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Acute myeloid leukemia, organism-specific biosystem (from KEGG)
    Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
  • Acute myeloid leukemia, conserved biosystem (from KEGG)
    Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
apoptotic mitochondrial changes IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
serine/threonine-protein kinase pim-2
NP_613072.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138606.2NP_613072.1  serine/threonine-protein kinase pim-2

    See identical proteins and their annotated locations for NP_613072.1

    Status: VALIDATED

    Source sequence(s)
    BC022727, L41495
    Consensus CDS
    CCDS29976.1
    UniProtKB/Swiss-Prot
    Q62070
    UniProtKB/TrEMBL
    Q8R1Z0
    Related
    ENSMUSP00000140602, ENSMUST00000190448
    Conserved Domains (2) summary
    smart00220
    Location:91345
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:90346
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p3 C57BL/6J

    Range
    7878306..7883432
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000042.1 Alternate Mm_Celera

    Range
    3586468..3591566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)