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    E2F3 E2F transcription factor 3 [ Homo sapiens ]

    Gene ID: 1871, updated on 5-Feb-2012
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    Summary

    Official Symbol
    E2F3provided by HGNC
    Official Full Name
    E2F transcription factor 3provided by HGNC
    Primary source
    HGNC:3115
    Locus tag
    RP1-177P22.2
    See related
    Ensembl:ENSG00000112242; HPRD:02693; MIM:600427; Vega:OTTHUMG00000016389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    E2F-3
    Summary
    The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
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    Genomic context

    Location :
    6p22
    Sequence :
    Chromosome: 6; NC_000006.11 (20402137..20493945)
    See E2F3 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L29 pseudogene 17 Neighboring gene membrane bound O-acyltransferase domain containing 1 Neighboring gene CDK5 regulatory subunit associated protein 1-like 1 Neighboring gene ribosomal protein L36a pseudogene 25 Neighboring gene SRY (sex determining region Y)-box 4

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. EBP1 is a novel E2F target gene regulated by transforming growth factor-β. Judah D, et al. PLoS One, 2010 Nov 10. PMID 21085677.
    2. Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells. Akao Y, et al. Cancer Lett, 2011 Jan 28. PMID 21067862.
    3. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. Casabonne D, et al. Haematologica, 2011 Feb. PMID 21048031.
    4. Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark. Revenko AS, et al. Mol Cell Biol, 2010 Nov. PMID 20855524.
    5. Characterization of E2F3a function in HepG2 liver cancer cells. Li W, et al. J Cell Biochem, 2010 Dec 1. PMID 20803551.

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data show that E2F is likely a central coordinator of multiple responses that culminate in regulation of EBP1 gene expression, and which may vary depending on cell type and context.
      Title: EBP1 is a novel E2F target gene regulated by transforming growth factor-β.
    2. E2F3a induces apoptosis in HepG2 cells and plays important roles in regulating transcription
      Title: Characterization of E2F3a function in HepG2 liver cancer cells.
    3. miR-34a targeting the Sirt1 and E2F3 genes could negatively regulate the resistance to 5-FU in human colorectal cancer DLD-1 cells.
      Title: Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells.
    4. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
    5. Data report that ANCCA directly interacts with E2F1 to E2F3 in its complex with MLL and that its N terminus interacts with both the N and C termini of E2F1.
      Title: Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark.
    6. the hypoxia component of ischemia may limit wound re-epithelialization by stabilizing HIF-1alpha, which induces miR-210 expression, resulting in the down-regulation of the cell-cycle regulatory protein E2F3
      Title: Hypoxia inducible microRNA 210 attenuates keratinocyte proliferation and impairs closure in a murine model of ischemic wounds.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
    8. these data reveal the novel ability of E2f3 to function as a master regulator of the DNA damage response.
      Title: E2F3 is a mediator of DNA damage-induced apoptosis.
    9. miR-128 can inhibit proliferation of glioma cells through one of its targets, E2F3a.
      Title: MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a.
    10. report confirms significant mRNA overexpression of KIF14 and E2F3 together in a large cohort of retinoblastoma tumors
      Title: KIF14 and E2F3 mRNA expression in human retinoblastoma and its phenotype association.
    Submit: New GeneRIF Correction See all (28)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001940.1 U75285.1 BIRC5    BIND  PubMed E2F3 (E2F-3) interacts with the BIRC5 (survivin) promoter. 
    NP_001940.1 NC_000003.9 CDC25A    BIND  PubMed E2F3 interacts with the Cdc25A promoter. 
    NP_001940.1 NC_000017.9 CDC6    BIND  PubMed E2F3 interacts with the Cdc6 promoter. 
    NP_001940.1 NC_000010.8 CDK1    BIND  PubMed E2F3 interacts with the Cdc2 promoter. 
    NP_001940.1 AAX63200.1 EAPP    BIND  PubMed E2F3 interacts with EAPP. 
    NP_001940.1 FHL2    BIND  PubMed E2F3 interacts with a molecule expressed by Gene FHL2. The precise molecular variant of FHL2 involved in this interaction is not specified. 
    NP_001940.1 NC_000011.8 GAB2    BIND  PubMed The Gab2 promoter region interacts with E2F3. 
    NP_001940.1 NC_000005.8 JMY    BIND  PubMed E2F3 interacts with the JMY promoter. 
    NP_001940.1 NC_000002.9 MSH2    BIND  PubMed E2F3 interacts with the MSH2 promoter. 
    NP_001940.1 J03910.1 MT1G    BIND  PubMed E2F3 interacts with the MT1G promoter. 
    NP_001940.1 NC_000020.9 MYBL2    BIND  PubMed E2F3 interacts with the B-myb promoter region. 
    NP_001940.1 NC_000014.7 PPP1R13B    BIND  PubMed E2F3 interacts with the PPP1R13B (ASPP1) promoter. 
    NP_001940.1 NP_036366.2 RYBP    BIND  PubMed E2F3 interacts with RYBP. 
    NP_001940.1 NC_000001.8 TP53BP2    BIND  PubMed E2F3 interacts with the TP53BP2 (ASPP2) promoter. 
    NP_001940.1 NC_000008.9 TP53INP1    BIND  PubMed E2F3 interacts with the TP53INP1 promoter. 
    NP_001940.1 NC_000023.8 UXT    BIND  PubMed E2F3 interacts with the UXT chromatin. 
    NP_001940.1     BIND  PubMed E2F-3 interacts with the E2F site. This interaction was modelled on a demonstrated interaction between E2F-3 and a synthetic dsDNA construct. 
    O00716 P20248 CCNA2    HPRD  PubMed  
    O00716 Q00526 CDK3    HPRD  PubMed  
    O00716 P06400 RB1    HPRD  PubMed  
    O00716 Q8N488 RYBP    HPRD  PubMed  
    O00716 P08047 SP1    HPRD  PubMed  
    O00716 Q14186 TFDP1    HPRD  PubMed  
    O00716 Q14188 TFDP2    HPRD  PubMed  
    O00716 P19532 TFE3    HPRD  PubMed  
    O00716 P25490 YY1    HPRD  PubMed  
    BioGRID:108203 BioGRID:118827 ATAD2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:108203 BioGRID:107076 BCL6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:108203 BioGRID:107777 CREBBP    BioGRID  PubMed Two-hybrid 
    BioGRID:108203 BioGRID:108565 FHL2    BioGRID  PubMed Two-hybrid 
    BioGRID:108203 BioGRID:109304 HCFC1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108203 BioGRID:116870 MGA    BioGRID  PubMed Two-hybrid 
    BioGRID:108203 BioGRID:113758 MLL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:108203 BioGRID:110690 MYBL2    BioGRID  PubMed Two-hybrid 
    BioGRID:108203 BioGRID:111557 PKIB    BioGRID  PubMed Two-hybrid 
    BioGRID:108203 BioGRID:115125 RNF144A    BioGRID  PubMed Two-hybrid 
    BioGRID:108203 BioGRID:116997 RYBP    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:108203 BioGRID:112567 SPIB    BioGRID  PubMed Two-hybrid 
    BioGRID:108203 BioGRID:203414 Sp1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:108203 BioGRID:112864 TEAD3    BioGRID  PubMed Two-hybrid 
    BioGRID:108203 BioGRID:112888 TFE3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:108203 BioGRID:113237 USF1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:108203 BioGRID:122403 WNK1    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Assembly of the pre-replicative complex, organism-specific biosystem (from REACTOME)
      Assembly of the pre-replicative complex, organism-specific biosystemDNA replication pre-initiation in eukaryotic cells begins with the formation of the pre-replicative complex (pre-RC) during the late M phase and continues in the G1 phase of the mitotic cell cycle, a...
    • Association of licensing factors with the pre-replicative complex, organism-specific biosystem (from REACTOME)
      Association of licensing factors with the pre-replicative complex, organism-specific biosystemThe eukaryotic six-subunit origin recognition complex (ORC) governs the initiation site of DNA replication and formation of the prereplication complex.
    • Bladder cancer, organism-specific biosystem (from KEGG)
      Bladder cancer, organism-specific biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • Bladder cancer, conserved biosystem (from KEGG)
      Bladder cancer, conserved biosystemThe urothelium covers the luminal surface of almost the entire urinary tract, extending from the renal pelvis, through the ureter and bladder, to the proximal urethra. The majority of urothelial carc...
    • CDC6 association with the ORC:origin complex, organism-specific biosystem (from REACTOME)
      CDC6 association with the ORC:origin complex, organism-specific biosystemCdc6 is a regulator of DNA replication initiation in both yeasts and human cells, but its mechanism of action differs between the two systems. Genetic studies in budding yeast (S. cerevisiae) and fis...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
      Cyclin D associated events in G1, organism-specific biosystemThree D-type cyclins are essential for progression from G1 to S-phase. These D cyclins bind to and activate both CDK4 and CDK6. The formation of all possible complexes between the D-type cyclins and...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • DNA Replication Pre-Initiation, organism-specific biosystem (from REACTOME)
      DNA Replication Pre-Initiation, organism-specific biosystemAlthough, DNA replication occurs in the S phase of the cell cycle, the formation of the DNA replication pre-initiation complex begins during G1 phase.
    • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      E2F transcription factor network, organism-specific biosystem
      E2F transcription factor network
    • G1 Phase, organism-specific biosystem (from REACTOME)
      G1 Phase, organism-specific biosystemEarly cell cycle progression in G1 is under the control of the D-type cyclins together with Cdk4 and Cdk6. An important target for these CDKs is the Retinoblastoma (Rb) protein, which when phosphoryl...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • G2 Phase, organism-specific biosystem (from REACTOME)
      G2 Phase, organism-specific biosystemThis is one of two 'gap' phases in the standard eukaryotic mitotic cell cycle. It is the interval between the completion of DNA synthesis and the beginning of mitosis. Protein synthesis occurs in t...
    • Glioma, organism-specific biosystem (from KEGG)
      Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • Glioma, conserved biosystem (from KEGG)
      Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • M/G1 Transition, organism-specific biosystem (from REACTOME)
      M/G1 Transition, organism-specific biosystemFinally, progression out of mitosis and division of the cell into two daughters (cytokinesis) requires the inactivation of Cyclin B - Cdc2 by ubiquitin-dependent proteolysis of Cyclin A and B, which ...
    • Melanoma, organism-specific biosystem (from KEGG)
      Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Melanoma, conserved biosystem (from KEGG)
      Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
      Mitotic G2-G2/M phases, organism-specific biosystem
      Mitotic G2-G2/M phases
    • Mitotic M-M/G1 phases, organism-specific biosystem (from REACTOME)
      Mitotic M-M/G1 phases, organism-specific biosystem
      Mitotic M-M/G1 phases
    • Non-small cell lung cancer, organism-specific biosystem (from KEGG)
      Non-small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Non-small cell lung cancer, conserved biosystem (from KEGG)
      Non-small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancer and represents a heter...
    • Pancreatic cancer, organism-specific biosystem (from KEGG)
      Pancreatic cancer, organism-specific biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pancreatic cancer, conserved biosystem (from KEGG)
      Pancreatic cancer, conserved biosystemInfiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA)...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Prostate cancer, organism-specific biosystem (from KEGG)
      Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Prostate cancer, conserved biosystem (from KEGG)
      Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
    • Regulation of DNA replication, organism-specific biosystem (from REACTOME)
      Regulation of DNA replication, organism-specific biosystemDNA replication is regulated at various levels via ORC proteins. This pathway includes annotation of individual events that lead to the regulation of replication.
    • Small cell lung cancer, organism-specific biosystem (from KEGG)
      Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Small cell lung cancer, conserved biosystem (from KEGG)
      Small cell lung cancer, conserved biosystemLung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% ...
    • Validated targets of C-MYC transcriptional activation, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional activation, organism-specific biosystem
      Validated targets of C-MYC transcriptional activation

    Clone Names

    • KIAA0075, MGC104598, DKFZp686C18211

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    core promoter binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cyclin-dependent protein kinase activity TAS
    Traceable Author Statement
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sequence-specific DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    G1 phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    G2 phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    		 PubMed 
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    transcription factor E2F3
    Names
    transcription factor E2F3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029591.1 RefSeqGene

      Range
      5001..96809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001243076.1 → NP_001230005.1  transcription factor E2F3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL136303, BU633769, CR749285
      UniProtKB/TrEMBL
      Q68DT0
      Conserved Domains (1) summary
      pfam02319
      Location:47 – 112
      Blast Score: 292
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    2. NM_001949.4 → NP_001940.1  transcription factor E2F3 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL132775, AL136303, BU633769, Y10479
      Consensus CDS
      CCDS4545.1
      UniProtKB/Swiss-Prot
      O00716
      Related
      ENSP00000262904, OTTHUMP00000018012, ENST00000346618, OTTHUMT00000043828
      Conserved Domains (1) summary
      pfam02319
      Location:178 – 243
      Blast Score: 296
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      20402137..20493945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      20346529..20438219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF547386.1 AAN17846.1
    genomic AL132775.29 CAI21471.1
    genomic AL136303.15 CAC28598.2
    genomic CH471087.1 EAW55421.1
      EAW55422.1
      EAW55423.1
    mRNA BC016847.1 AAH16847.1
    mRNA BC099908.1 AAH99908.1
    mRNA BC114554.1 AAI14555.1
    mRNA BU633769.1 None
    mRNA CR749285.1 CAH18140.1
    mRNA D38550.1 BAA07553.1
    mRNA W38841.1 None
    mRNA Y10479.1 CAA71504.1
    other-genetic BC156367.1 AAI56368.1
    other-genetic BC172526.1 AAI72526.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    O00716.1 GenPept UniProtKB/Swiss-Prot:O00716
    Q24JQ3 GenPept UniProtKB/TrEMBL:Q24JQ3
    Q499G5 GenPept UniProtKB/TrEMBL:Q499G5
    Q68DT0 GenPept UniProtKB/TrEMBL:Q68DT0
    Q96AR0 GenPept UniProtKB/TrEMBL:Q96AR0
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

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