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Pik3c2a phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide [ Mus musculus (house mouse) ]

Gene ID: 18704, updated on 8-May-2016
Official Symbol
Pik3c2aprovided by MGI
Official Full Name
phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptideprovided by MGI
Primary source
MGI:MGI:1203729
See related
Ensembl:ENSMUSG00000030660 Vega:OTTMUSG00000058790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cpk-m; PI3KC2
Orthologs
Location:
7 F1; 7 61.62 cM
Exon count:
34
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 7 NC_000073.6 (116337265..116444557, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (123480790..123586972, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family A member 7 Neighboring gene uncharacterized LOC102637815 Neighboring gene small nucleolar RNA, C/D box 14A Neighboring gene ribosomal protein S13 Neighboring gene predicted gene, 40453 Neighboring gene predicted gene, 32676 Neighboring gene nucleobindin 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
autophagosome organization IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to starvation IGI
Inferred from Genetic Interaction
more info
PubMed 
endocytosis ISO
Inferred from Sequence Orthology
more info
 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of zinc ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3-phosphate biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
Names
PI3K-C2-alpha
p170
phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
phosphoinositide 3-kinase-C2-alpha
ptdIns-3-kinase C2 subunit alpha
NP_035213.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011083.2NP_035213.2  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

    See identical proteins and their annotated locations for NP_035213.2

    Status: VALIDATED

    Source sequence(s)
    AC104918, AK136732, BC096553, BY014484, BY034035, BY726923, U55772
    Consensus CDS
    CCDS52371.1
    UniProtKB/Swiss-Prot
    Q61194
    UniProtKB/TrEMBL
    F8VPL2
    Related
    ENSMUSP00000126092, OTTMUSP00000075255, ENSMUST00000170430, OTTMUST00000144368
    Conserved Domains (6) summary
    cd07289
    Location:14261534
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:677849
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:15601681
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:8691038
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    pfam00794
    Location:420513
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cd05176
    Location:10431395
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p3 C57BL/6J

    Range
    116337265..116444557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507440.2XP_006507503.1  

    See identical proteins and their annotated locations for XP_006507503.1

    UniProtKB/TrEMBL
    F8VPL2
    Related
    ENSMUSP00000146181, OTTMUSP00000075257, ENSMUST00000206219, OTTMUST00000144373
    Conserved Domains (6) summary
    cd07289
    Location:14261534
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:677849
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:15601681
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:8691038
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    pfam00794
    Location:420513
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cd05176
    Location:10431395
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
  2. XM_006507441.2XP_006507504.1  

    See identical proteins and their annotated locations for XP_006507504.1

    Conserved Domains (6) summary
    cd07289
    Location:10091117
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:260432
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:11431264
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:452621
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    pfam00794
    Location:396
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cd05176
    Location:626978
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha

Alternate Mm_Celera

Genomic

  1. AC_000029.1 Alternate Mm_Celera

    Range
    116275791..116376830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)