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snai-1 C2H2-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 186874, updated on 23-Nov-2023

Summary

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Gene symbol
snai-1
Gene description
C2H2-type domain-containing protein
Primary source
WormBase:WBGene00019299
Locus tag
CELE_K02D7.2
See related
AllianceGenome:WB:WBGene00019299
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in PHAL; PHAR; PHBL; PHBR; and amphid neurons. Human ortholog(s) of this gene implicated in Waardenburg syndrome type 2D and piebaldism. Orthologous to several human genes including SNAI1 (snail family transcriptional repressor 1) and SNAI2 (snail family transcriptional repressor 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See snai-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (311484..313715, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Purine nucleoside phosphorylase Neighboring gene Sugar transporter SWEET1 Neighboring gene ncRNA Neighboring gene Microsomal triglyceride transfer protein homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development. Jin Y, et al. Cancer Lett, 2015 Jun 28. PMID 25827072, Free PMC Article
  2. The C. elegans Snail homolog CES-1 can activate gene expression in vivo and share targets with bHLH transcription factors. Reece-Hoyes JS, et al. Nucleic Acids Res, 2009 Jun. PMID 19372275, Free PMC Article
  3. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
C2H2-type domain-containing protein
NP_499902.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    311484..313715 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_067501.4 → NP_499902.2  C2H2-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_499902.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45103
    Conserved Domains (3) summary
    COG5048
    Location:98 → 155
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:98 → 118
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:138 → 163
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
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