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Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A [ Mus musculus (house mouse) ]

Gene ID: 18671, updated on 28-May-2016
Official Symbol
Abcb1aprovided by MGI
Official Full Name
ATP-binding cassette, sub-family B (MDR/TAP), member 1Aprovided by MGI
Primary source
MGI:MGI:97570
See related
Ensembl:ENSMUSG00000040584 Vega:OTTMUSG00000029053
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pgp; Mdr3; P-gp; Pgy3; Abcb4; Evi32; Mdr1a; Pgy-3; mdr-3
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs. [provided by RefSeq, Jul 2008]
Location:
5 A1; 5 3.43 cM
Exon count:
31
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (8567091..8748575)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (8660092..8748570)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 25, member 40 Neighboring gene DBF4 zinc finger Neighboring gene RUN domain containing 3B Neighboring gene predicted gene, 31157 Neighboring gene predicted gene 5106 Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 1B Neighboring gene ATP-binding cassette, sub-family B (MDR/TAP), member 4 Neighboring gene calponin 3, acidic pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • ABC transporters, organism-specific biosystem (from KEGG)
    ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC transporters, conserved biosystem (from KEGG)
    ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC-family proteins mediated transport, organism-specific biosystem (from REACTOME)
    ABC-family proteins mediated transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Abacavir transmembrane transport, organism-specific biosystem (from REACTOME)
    Abacavir transmembrane transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Abacavir transport and metabolism, organism-specific biosystem (from REACTOME)
    Abacavir transport and metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Bile secretion, organism-specific biosystem (from KEGG)
    Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Bile secretion, conserved biosystem (from KEGG)
    Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystem (from WikiPathways)
    Nuclear receptors in lipid metabolism and toxicity, organism-specific biosystemNuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. Ho...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled IDA
Inferred from Direct Assay
more info
PubMed 
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
xenobiotic-transporting ATPase activity EXP
Inferred from Experiment
more info
PubMed 
xenobiotic-transporting ATPase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent IBA
Inferred from Biological aspect of Ancestor
more info
 
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent IBA
Inferred from Biological aspect of Ancestor
more info
 
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IBA
Inferred from Biological aspect of Ancestor
more info
 
carbohydrate export ISO
Inferred from Sequence Orthology
more info
 
daunorubicin transport ISO
Inferred from Sequence Orthology
more info
 
drug export ISO
Inferred from Sequence Orthology
more info
 
drug transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
drug transport IDA
Inferred from Direct Assay
more info
PubMed 
establishment of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
hormone transport ISO
Inferred from Sequence Orthology
more info
 
intestinal absorption ISO
Inferred from Sequence Orthology
more info
 
maintenance of blood-brain barrier ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of antigen processing and presentation of peptide antigen via MHC class I IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of response to drug ISO
Inferred from Sequence Orthology
more info
 
stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
brush border membrane ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
intercellular canaliculus IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
multidrug resistance protein 1A
Names
ATP-binding cassette sub-family B member 1A
ATP-binding cassette, sub-family B (MDR/TAP), member 4
ATP-binding cassette, subfamily B, member 1A
P glycoprotein 3
P-glycoprotein 3
ecotropic viral integration site 32
multi-drug resistance 3
multidrug resistance protein 3
multiple drug resistant 1a
NP_035206.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011076.2NP_035206.2  multidrug resistance protein 1A

    See identical proteins and their annotated locations for NP_035206.2

    Status: VALIDATED

    Source sequence(s)
    AC121955, AC140398, AK008292, M33581
    Consensus CDS
    CCDS19084.1
    UniProtKB/Swiss-Prot
    P21447
    UniProtKB/TrEMBL
    Q9CVG4
    Related
    ENSMUSP00000041204, OTTMUSP00000037023, ENSMUST00000047753, OTTMUST00000072084
    Conserved Domains (3) summary
    cd03249
    Location:10311270
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:471263
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:50341
    ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

    Range
    8567091..8748575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503555.2XP_006503618.1  

    See identical proteins and their annotated locations for XP_006503618.1

    UniProtKB/Swiss-Prot
    P21447
    Conserved Domains (3) summary
    cd03249
    Location:10311270
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:471263
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:50341
    ABC_membrane; ABC transporter transmembrane region
  2. XM_006503556.2XP_006503619.1  

    See identical proteins and their annotated locations for XP_006503619.1

    UniProtKB/Swiss-Prot
    P21447
    Conserved Domains (3) summary
    cd03249
    Location:10311270
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:471263
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:50341
    ABC_membrane; ABC transporter transmembrane region

Alternate Mm_Celera

Genomic

  1. AC_000027.1 Alternate Mm_Celera

    Range
    8580580..8668151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)