AGTR2 angiotensin II receptor, type 2 [Homo sapiens] - Gene

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Summary

Official Symbol: AGTR2provided by HGNC
Official Full Name: angiotensin II receptor, type 2provided by HGNC
Primary source: HGNC:338
See related: Ensembl:ENSG00000180772; HPRD:02071; MIM:300034; Vega:OTTHUMG00000022243
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AT2; ATGR2; MRX88
Summary: The protein encoded by this gene belongs to the G-protein coupled receptor 1 family, and functions as a receptor for angiotensin II. It is an intergral membrane protein that is highly expressed in fetus, but scantily in adult tissues, except brain, adrenal medulla, and atretic ovary. This receptor has been shown to mediate programmed cell death and this apoptotic function may play an important role in developmental biology and pathophysiology. Mutations in this gene are been associated with X-linked mental retardation. [provided by RefSeq, Jan 2010]

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Genomic context

Location :: Xq22-q23

Sequence :: Chromosome: X; NC_000023.10 (115301958..115306225)

See AGTR2 in Epigenomics, MapViewer

Chromosome X - NC_000023.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Angiotensin II type 1 receptor, but no type 2 receptor, interferes with the insulin-induced nitric oxide production in endothelial cells.
Title: Angiotensin II type 1 receptor, but no type 2 receptor, interferes with the insulin-induced nitric oxide production in HUVECs.
The association of the mutated genotypes Met235Thr-AGT, Thr174Met-AGT, I/D-ACE, A2350G-ACE, A1166C-AT2R1, C3123A-AT2R2, (83)A/G-REN with the risk and outcome of pre-eclampsia, was evaluated.
Title: Maternal/newborn genotype contribution of the renin-angiotensin system (Met235Thr, Thr174Met, I/D-ACE, A2350G-ACE, A1166C-AT2R1, C3123A- AT2R2, 83A/G-REN) to the risk of pre-eclampsia: a Romanian study.
The data suggested that diameter of the retinal arterioles might be associated with the angiotensin II Type 2 Receptor 1675G/A polymorphism.
Title: Are retinal microvascular phenotypes associated with the 1675G/A polymorphism in the angiotensin II type-2 receptor gene?
This study therefore confirms a hypertrophy-modulating effect for AT(2)R also in hypertrophic cardiomyopathy.
Title: Genetic variation in angiotensin II type 2 receptor gene influences extent of left ventricular hypertrophy in hypertrophic cardiomyopathy independent of blood pressure.
The study reveals a previously unrecognized mechanism of angiotensin receptor cross-talk involving cross-inhibition of AT1receptor internalization through heteromerization with the AT2 receptor subtype.
Title: Heteromerization of angiotensin receptors changes trafficking and arrestin recruitment profiles.
The present findings suggest that the homozygous form of the ATR gene may make improving systolic blood pressure and some obesity-related metabolic parameters through a dietary intervention difficult among obese women.
Title: Genetic polymorphisms of the renin-angiotensin system and obesity-related metabolic changes in response to low-energy diets in obese women.
Specific expression patterns for AGTR1 and AGTR2 in distinct trophoblast populations at the maternal-fetal interface and suggests that Ang II plays a role in placental development and generation of extravillous trophoblasts.
Title: Differential expression of angiotensin II type 1 and type 2 receptors at the maternal-fetal interface: potential roles in early placental development.
A1166C genetic variation of the angiotensin II type I receptor gene may not have a major role in susceptibility to coronary heart disease [meta-analysis]
Title: A1166C genetic variation of the angiotensin II type I receptor gene and susceptibility to coronary heart disease: collaborative of 53 studies with 20,435 cases and 23,674 controls.
ACE DD and AT2R GG genotypes are associated with chronic kidney disease and scarring in PUV
Title: Association of angiotensin converting enzyme and angiotensin type 2 receptor gene polymorphisms with renal damage in posterior urethral valves.
Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice
Title: Angiotensin II type 2 receptor signaling significantly attenuates growth of murine pancreatic carcinoma grafts in syngeneic mice.

Submit: New GeneRIF Correction See all (98)

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Phenotypes

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.

Mental retardation, X-linked 88

MIM: 300852

Mental retardation, X-linked-88

MIM: 300034

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Products	Interactant	Other Gene	Source	Pubs	Description
P50052	P12821	ACE	HPRD	PubMed
P50052	P01019	AGT	HPRD	PubMed
P50052	P21860	ERBB3	HPRD	PubMed
P50052	P04899	GNAI2	HPRD	PubMed
P50052	P08754	GNAI3	HPRD	PubMed
P50052	Mitochondrial tumor suppressor gene 1	MTUS1	HPRD	PubMed
P50052	P42338	PIK3CB	HPRD	PubMed
P50052	Q05516	ZBTB16	HPRD	PubMed
BioGRID:106692	BioGRID:121356	AGTRAP	BioGRID	PubMed	Reconstituted Complex
BioGRID:106692	BioGRID:121573	MTUS1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid

Function	Evidence Code	Pubs
G-protein coupled receptor activity	IEA Inferred from Electronic Annotation more info
angiotensin type II receptor activity	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
receptor activity	IEA Inferred from Electronic Annotation more info
receptor antagonist activity	TAS Traceable Author Statement more info	PubMed
signal transducer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway	IC Inferred by Curator more info	PubMed
G-protein signaling, coupled to cGMP nucleotide second messenger	ISS Inferred from Sequence or Structural Similarity more info	PubMed
behavior	IMP Inferred from Mutant Phenotype more info	PubMed
behavior	ISS Inferred from Sequence or Structural Similarity more info
blood vessel remodeling	TAS Traceable Author Statement more info	PubMed
brain development	NAS Non-traceable Author Statement more info	PubMed
brain renin-angiotensin system	IEA Inferred from Electronic Annotation more info
cell surface receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
inflammatory response	IEA Inferred from Electronic Annotation more info
intracellular protein kinase cascade	ISS Inferred from Sequence or Structural Similarity more info	PubMed
negative regulation of blood vessel endothelial cell migration	NAS Non-traceable Author Statement more info	PubMed
negative regulation of cell growth	TAS Traceable Author Statement more info	PubMed
negative regulation of heart rate	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of nerve growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of signal transduction	TAS Traceable Author Statement more info	PubMed
nitric oxide mediated signal transduction	IC Inferred by Curator more info	PubMed
nitric oxide mediated signal transduction	TAS Traceable Author Statement more info	PubMed
positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
positive regulation of metanephric glomerulus development	IEA Inferred from Electronic Annotation more info
positive regulation of nitric oxide biosynthetic process	IC Inferred by Curator more info	PubMed
positive regulation of nitric-oxide synthase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
positive regulation of vasodilation	IDA Inferred from Direct Assay more info	PubMed
regulation of blood pressure	TAS Traceable Author Statement more info	PubMed
regulation of metanephros size	IEA Inferred from Electronic Annotation more info
regulation of systemic arterial blood pressure by circulatory renin-angiotensin	ISS Inferred from Sequence or Structural Similarity more info
vasodilation by angiotensin involved in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
integral to plasma membrane	IC Inferred by Curator more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: type-2 angiotensin II receptor

Names: type-2 angiotensin II receptor; angiotensin II type-2 receptor

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016326.1 RefSeqGene

Range

5001..9268

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000686.4 → NP_000677.2 type-2 angiotensin II receptor

Status: REVIEWED

Source sequence(s)

AI911273, AL732602, BC095504, CR738498, DA538369, U16957

Consensus CDS

CCDS14569.1

UniProtKB/Swiss-Prot

P50052

Related

ENSP00000360973, OTTHUMP00000023878, ENST00000371906, OTTHUMT00000057984

Conserved Domains (1) summary

pfam00001
Location:68 – 318
Blast Score: 459

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000023.10 Reference GRCh37.p5 Primary Assembly

Range

115301958..115306225

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000155.1 Alternate HuRef

Range

104838955..104843260

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL732602.5	CAI40984.1
genomic	AY322542.1	AAP84355.1
genomic	AY324607.1	AAP72969.1
genomic	AY536522.1	AAS45437.1
genomic	CH471234.1	EAW51502.1
genomic	L34579.1	AAA98990.1
genomic	U10273.1	AAA61794.1
genomic	U15592.1	AAA50762.1
genomic	U20860.1	AAA85851.1
genomic	U27478.1	AAA84900.1
genomic	X87722.1	None
mRNA	AI911273.1	None
mRNA	AK313927.1	BAG36648.1
mRNA	BC095504.1	AAH95504.1
mRNA	CR541969.1	CAG46767.1
mRNA	CR738498.1	None
mRNA	DA538369.1	None
mRNA	U16957.1	AAA67753.1
mRNA	X87723.1	CAA61022.1