Pdha1 pyruvate dehydrogenase E1 alpha 1 [Mus musculus (house mouse)] - Gene

Summary

Go to the top of the page Help

Official Symbol: Pdha1provided by MGI
Official Full Name: pyruvate dehydrogenase E1 alpha 1provided by MGI
Primary source: MGI:97532
Locus tag: RP23-36P16.4
See related: Ensembl:ENSMUSG00000031299; Vega:OTTMUSG00000019453
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pdha-1

Genomic context

Go to the top of the page Help

Location :: X F3-F4; X 73.95 cM

Sequence :: Chromosome: X; NC_000086.7 (160122219..160138336, complement)

See Pdha1 in Epigenomics, MapViewer

Chromosome X - NC_000086.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Liver-specific pyruvate dehydrogenase complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin sensitivity.
Title: Liver-specific pyruvate dehydrogenase complex deficiency upregulates lipogenesis in adipose tissue and improves peripheral insulin sensitivity.
PGC-1alpha regulates PDH-E1alpha protein content in parallel with mitochondrial oxidative proteins, but does not seem to influence PDH regulation in mouse skeletal muscle in response to fasting and in recovery from exercise.
Title: PGC-1alpha increases PDH content but does not change acute PDH regulation in mouse skeletal muscle.
Embryos carrying predominantly the Pdha1(deletion in exon 8, Deltaex8) allele were found to be globally delayed in development by 9.5 days postcoitus, with resorption occurring over the following several days.
Title: Inactivation of the murine pyruvate dehydrogenase (Pdha1) gene and its effect on early embryonic development.

Submit: New GeneRIF Correction

Alleles

Go to the top of the page Help

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (1) 1 citation
Targeted (knock-out) (1) 1 citation

Pathways from BioSystems

Go to the top of the page Help

Acetylcholine Synthesis, organism-specific biosystem (from WikiPathways)
Acetylcholine Synthesis, organism-specific biosystemAcetylcholine is an important neurotransmitter. It can be rapidly released in the synaptic cleft upon activation of the neuron. In the synaptic cleft the compound is degraded rapidly into choline and...
Butanoate metabolism, organism-specific biosystem (from KEGG)
Butanoate metabolism, organism-specific biosystem
Butanoate metabolism
Butanoate metabolism, conserved biosystem (from KEGG)
Butanoate metabolism, conserved biosystem
Butanoate metabolism
Citrate cycle (TCA cycle), organism-specific biosystem (from KEGG)
Citrate cycle (TCA cycle), organism-specific biosystemThe citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form ...
Citrate cycle (TCA cycle), conserved biosystem (from KEGG)
Citrate cycle (TCA cycle), conserved biosystemThe citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form ...
Glycolysis / Gluconeogenesis, organism-specific biosystem (from KEGG)
Glycolysis / Gluconeogenesis, organism-specific biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
Glycolysis / Gluconeogenesis, conserved biosystem (from KEGG)
Glycolysis / Gluconeogenesis, conserved biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
Glycolysis and Gluconeogenesis, organism-specific biosystem (from WikiPathways)
Glycolysis and Gluconeogenesis, organism-specific biosystem
Glycolysis and Gluconeogenesis
HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pyruvate metabolism, organism-specific biosystem (from KEGG)
Pyruvate metabolism, organism-specific biosystem
Pyruvate metabolism
Pyruvate metabolism, organism-specific biosystem (from REACTOME)
Pyruvate metabolism, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pyruvate metabolism, conserved biosystem (from KEGG)
Pyruvate metabolism, conserved biosystem
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystem (from REACTOME)
Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pyruvate oxidation, pyruvate => acetyl-CoA, organism-specific biosystem (from KEGG)
Pyruvate oxidation, pyruvate => acetyl-CoA, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Pyruvate oxidation, pyruvate => acetyl-CoA, conserved biosystem (from KEGG)
Pyruvate oxidation, pyruvate => acetyl-CoA, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
Regulation of pyruvate dehydrogenase (PDH) complex, organism-specific biosystem (from REACTOME)
Regulation of pyruvate dehydrogenase (PDH) complex, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TCA Cycle, organism-specific biosystem (from WikiPathways)
TCA Cycle, organism-specific biosystemThe [[wikipedia:citric_acid_cycle|citric acid cycle]], also known as the tricarboxylic acid cycle (TCA cycle) or the Krebs cycle, (or rarely, the Szent-Gyorgyi-Krebs cycle) is a series of enzyme-cata...
The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem (from REACTOME)
The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystemcomputationally inferred pathway (not manually curated)
acetyl-CoA biosynthesis (from pyruvate), organism-specific biosystem (from BIOCYC)
acetyl-CoA biosynthesis (from pyruvate), organism-specific biosystem
acetyl-CoA biosynthesis (from pyruvate)
superpathway of acetyl-CoA biosynthesis, organism-specific biosystem (from BIOCYC)
superpathway of acetyl-CoA biosynthesis, organism-specific biosystem
superpathway of acetyl-CoA biosynthesis

General gene information

Go to the top of the page Help

Markers

Pdha1 (e-PCR), detects polymorphism
- UniSTS:546585

Pdha1 (e-PCR), detects polymorphism
- UniSTS:144154

Pdha1 (e-PCR), detects polymorphism
- UniSTS:546586

Pdha1 (e-PCR), detects polymorphism
- UniSTS:546926

Homology

Homologs of the Pdha1 gene: The Pdha1 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, A.thaliana, and rice.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
oxidoreductase activity	IEA Inferred from Electronic Annotation more info
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	IEA Inferred from Electronic Annotation more info
pyruvate dehydrogenase (acetyl-transferring) activity	ISO Inferred from Sequence Orthology more info
pyruvate dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
pyruvate dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acetyl-CoA biosynthetic process from pyruvate	ISO Inferred from Sequence Orthology more info
carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
glucose metabolic process	IEA Inferred from Electronic Annotation more info
glycolysis	IEA Inferred from Electronic Annotation more info
metabolic process	IEA Inferred from Electronic Annotation more info
oxidation-reduction process	IMP Inferred from Mutant Phenotype more info	PubMed
oxidation-reduction process	ISO Inferred from Sequence Orthology more info
tricarboxylic acid cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	ISO Inferred from Sequence Orthology more info
pyruvate dehydrogenase complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Names: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; PDHE1-A type I; pyruvate dehydrogenase E1alpha subunit

NP_032836.1

EC 1.2.4.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008810.2 → NP_032836.1 pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor

Status: PROVISIONAL

Source sequence(s)

BC007142

Consensus CDS

CCDS41195.1

UniProtKB/Swiss-Prot

P35486

UniProtKB/TrEMBL

Q3UFJ3

Related

ENSMUSP00000033662, OTTMUSP00000020974, ENSMUST00000033662, OTTMUST00000046449

Conserved Domains (2) summary

cd02000
Location:64 – 353
Blast Score: 951

TPP_E1_PDC_ADC_BCADC; Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain ...

TIGR03182
Location:58 – 370
Blast Score: 1328

PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000086.7 Reference GRCm38.p1 C57BL/6J

Range

160122219..160138336, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000042.1 Alternate Mm_Celera

Range

143366647..143382812, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01205634.1	None
genomic	AAHY01205635.1	None
genomic	AL845167.7 (104671..120788)	None
genomic	CH466571.2	EDL40808.1	mixed
mRNA	AK145718.1	BAE26608.1	C57BL/6J
mRNA	AK148459.1	BAE28567.1	C57BL/6J
mRNA	AK167987.1	BAE39978.1	DBA/2
mRNA	AK168152.1	BAE40117.1	DBA/2
mRNA	AK169289.1	BAE41046.1	C57BL/6J
mRNA	AK186057.1	None
mRNA	AK187913.1	None
mRNA	AK191895.1	None
mRNA	AK205841.1	None
mRNA	AK212590.1	None
mRNA	AL355693.1	None
mRNA	BC007142.1	AAH07142.1	FVB/N
mRNA	M76727.1	AAA53046.1	B6 x CBA/J F1