Pdgfa platelet derived growth factor, alpha [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Pdgfaprovided by MGI
Official Full Name: platelet derived growth factor, alphaprovided by MGI
Primary source: MGI:97527
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus

Genomic context

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Location :: 5 G2; 5 77.65 cM

Sequence :: Chromosome: 5; NC_000071.6 (138976971..138994953, complement)

See Pdgfa in Epigenomics, MapViewer

Chromosome 5 - NC_000071.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pdgf signaling potentiates Wnt2-Wnt7b signaling to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper development of endoderm-derived organs, such as the lung
Title: Wnt ligands signal in a cooperative manner to promote foregut organogenesis.
These results suggest that PDGF functions as a positive regulator in the final differentiation phase of tongue muscle cells in mouse embryos.
Title: The function of platelet-derived growth factor in the differentiation of mouse tongue striated muscle.
analysis of the cell of origin of NF1- and PDGF-driven glioblastomas
Title: The probable cell of origin of NF1- and PDGF-driven glioblastomas.
the serum-induced increase in cell surface GLUT4 levels is not due to inhibition of its internalization and is not mediated by insulin, PDGF, IGF-1, or HGF
Title: A serum factor induces insulin-independent translocation of GLUT4 to the cell surface which is maintained in insulin resistance.
PDGF protects neurons from H2O2-induced cytotoxicity, and that PI-3K/Akt and MAPK pathways are involved in the protective effects; PDGF-BB exerted more potent neuroprotective effects than PDGF-AA
Title: Neuroprotective effects of PDGF against oxidative stress and the signaling pathway involved.
These results imply a central role of NFI-C in the interplay of the two signaling pathways and in regulation of the progression of tissue regeneration.
Title: Nuclear factor I-C links platelet-derived growth factor and transforming growth factor beta1 signaling to skin wound healing progression.
During kidney development, PDGFR beta-mediated reactive oxygen species generation and Ca(2+) influx suppress PDGF AA-induced chemotaxis in metanephric mesenchyme.
Title: PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA.
study identified PDGF-A as a candidate epicardium-derived secreted mitogen
Title: PDGF-A as an epicardial mitogen during heart development.
One mechanism accounting for the PDGF induction of Glut4 translocation is the suppression of the Munc18c negative regulation of Syntaxin 4 function.
Title: Tyrosine phosphorylation of Munc18c regulates platelet-derived growth factor-stimulated glucose transporter 4 translocation in 3T3L1 adipocytes.
FGF and PDGF have roles in cell proliferation and migration in osteoblastic cells
Title: Differential effect of FGF and PDGF on cell proliferation and migration in osteoblastic cells.

Submit: New GeneRIF Correction See all (21)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (1) 1 citation

Pathways from BioSystems

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Adaptive Immune System, organism-specific biosystem (from REACTOME)
Adaptive Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Constitutive PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
Constitutive PI3K/AKT Signaling in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Cytokines and Inflammatory Response (BioCarta), organism-specific biosystem (from WikiPathways)
Cytokines and Inflammatory Response (BioCarta), organism-specific biosystemSee BioCarta version: http://www.biocarta.com/pathfiles/h_inflamPathway.asp
DAP12 interactions, organism-specific biosystem (from REACTOME)
DAP12 interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
DAP12 signaling, organism-specific biosystem (from REACTOME)
DAP12 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Disease, organism-specific biosystem (from REACTOME)
Disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signal transduction, organism-specific biosystem (from REACTOME)
Downstream signal transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Downstream signaling of activated FGFR, organism-specific biosystem (from REACTOME)
Downstream signaling of activated FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
Focal Adhesion, organism-specific biosystem (from WikiPathways)
Focal Adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, organism-specific biosystem (from KEGG)
Focal adhesion, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
Focal adhesion, conserved biosystem (from KEGG)
Focal adhesion, conserved biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
GAB1 signalosome, organism-specific biosystem (from REACTOME)
GAB1 signalosome, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Gap junction, organism-specific biosystem (from KEGG)
Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Gap junction, conserved biosystem (from KEGG)
Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
Glioma, organism-specific biosystem (from KEGG)
Glioma, organism-specific biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
Glioma, conserved biosystem (from KEGG)
Glioma, conserved biosystemGliomas are the most common of the primary brain tumors and account for more than 40% of all central nervous system neoplasms. Gliomas include tumours that are composed predominantly of astrocytes (a...
HTLV-I infection, organism-specific biosystem (from KEGG)
HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
HTLV-I infection, conserved biosystem (from KEGG)
HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
Melanoma, organism-specific biosystem (from KEGG)
Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
Melanoma, conserved biosystem (from KEGG)
Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI-3K cascade, organism-specific biosystem (from REACTOME)
PI-3K cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K events in ERBB2 signaling, organism-specific biosystem (from REACTOME)
PI3K events in ERBB2 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K events in ERBB4 signaling, organism-specific biosystem (from REACTOME)
PI3K events in ERBB4 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
PI3K/AKT Signaling in Cancer, organism-specific biosystem (from REACTOME)
PI3K/AKT Signaling in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PI3K/AKT activation, organism-specific biosystem (from REACTOME)
PI3K/AKT activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
PIP3 activates AKT signaling, organism-specific biosystem (from REACTOME)
PIP3 activates AKT signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
Platelet activation, signaling and aggregation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Platelet degranulation, organism-specific biosystem (from REACTOME)
Platelet degranulation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Prostate cancer, organism-specific biosystem (from KEGG)
Prostate cancer, organism-specific biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Prostate cancer, conserved biosystem (from KEGG)
Prostate cancer, conserved biosystemProstate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of...
Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
Regulation of Actin Cytoskeleton, organism-specific biosystem
Regulation of Actin Cytoskeleton
Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
Regulation of actin cytoskeleton, organism-specific biosystem
Regulation of actin cytoskeleton
Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
Regulation of actin cytoskeleton, conserved biosystem
Regulation of actin cytoskeleton
Renal cell carcinoma, organism-specific biosystem (from KEGG)
Renal cell carcinoma, organism-specific biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
Renal cell carcinoma, conserved biosystem (from KEGG)
Renal cell carcinoma, conserved biosystemRenal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal canc...
Response to elevated platelet cytosolic Ca2+, organism-specific biosystem (from REACTOME)
Response to elevated platelet cytosolic Ca2+, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR, organism-specific biosystem (from REACTOME)
Signaling by EGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by EGFR in Cancer, organism-specific biosystem (from REACTOME)
Signaling by EGFR in Cancer, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB2, organism-specific biosystem (from REACTOME)
Signaling by ERBB2, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by ERBB4, organism-specific biosystem (from REACTOME)
Signaling by ERBB4, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR, organism-specific biosystem (from REACTOME)
Signaling by FGFR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by FGFR in disease, organism-specific biosystem (from REACTOME)
Signaling by FGFR in disease, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by PDGF, organism-specific biosystem (from REACTOME)
Signaling by PDGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by SCF-KIT, organism-specific biosystem (from REACTOME)
Signaling by SCF-KIT, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
Signaling by the B Cell Receptor (BCR), organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer

General gene information

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Markers

Pdgfa (e-PCR), detects polymorphism
- UniSTS:144149

Pdgfa (e-PCR), detects polymorphism
- UniSTS:464685

Homology

Homologs of the Pdgfa gene: The Pdgfa gene is conserved in human, Rhesus monkey, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
cell surface binding	ISO Inferred from Sequence Orthology more info
collagen binding	ISO Inferred from Sequence Orthology more info
eukaryotic cell surface binding	ISO Inferred from Sequence Orthology more info
growth factor activity	IEA Inferred from Electronic Annotation more info
platelet-derived growth factor binding	ISO Inferred from Sequence Orthology more info
platelet-derived growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
platelet-derived growth factor receptor binding	ISO Inferred from Sequence Orthology more info
protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
angiogenesis	IDA Inferred from Direct Assay more info	PubMed
blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
cell projection assembly	IDA Inferred from Direct Assay more info	PubMed
digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
hair follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
lung alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative chemotaxis	ISO Inferred from Sequence Orthology more info
negative regulation of phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
negative regulation of platelet activation	ISO Inferred from Sequence Orthology more info
organ morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
organ morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
platelet-derived growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
positive regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
positive regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
positive regulation of cell division	IEA Inferred from Electronic Annotation more info
positive regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
positive regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
positive regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of phosphatidylinositol 3-kinase cascade	IBA Inferred from Biological aspect of Ancestor more info
positive regulation of phosphatidylinositol 3-kinase cascade	ISO Inferred from Sequence Orthology more info
positive regulation of protein autophosphorylation	IBA Inferred from Biological aspect of Ancestor more info
positive regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
positive regulation of protein kinase B signaling cascade	ISO Inferred from Sequence Orthology more info
regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
response to wounding	ISO Inferred from Sequence Orthology more info
skin development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cell surface	ISO Inferred from Sequence Orthology more info
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISO Inferred from Sequence Orthology more info
membrane	IEA Inferred from Electronic Annotation more info
microvillus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: platelet-derived growth factor subunit A

Names: platelet-derived growth factor subunit A; PDGF-1; PDGF subunit A; platelet-derived growth factor A chain; platelet-derived growth factor alpha polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008808.3 → NP_032834.1 platelet-derived growth factor subunit A precursor

Status: PROVISIONAL

Source sequence(s)

AC117698

Consensus CDS

CCDS19802.1

UniProtKB/Swiss-Prot

P20033

UniProtKB/TrEMBL

Q99L56

Conserved Domains (2) summary

cd00135
Location:94 – 182
Blast Score: 218

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...

pfam04692
Location:21 – 95
Blast Score: 282

PDGF_N; Platelet-derived growth factor, N terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000071.6 Reference GRCm38.p1 C57BL/6J

Range

138976971..138994953, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000027.1 Alternate Mm_Celera

Range

136032139..136049986, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01050154.1	None
genomic	AAHY01050155.1 (416..1552)	None
genomic	AC117698.19 (101974..119957)	None
genomic	CH466529.2	EDL19178.1	mixed
		EDL19179.1	mixed
genomic	S66868.1	None	BALB/c
genomic	S66869.1	None	BALB/c
genomic	S66870.1	None	BALB/c
genomic	S66871.1	None	BALB/c
genomic	S66872.1	None	BALB/c
genomic	S66873.1	AAB28740.2	BALB/c
genomic	S66874.1	AAB28741.2	BALB/c
mRNA	AK017169.1	BAB30622.1	C57BL/6J
mRNA	AK142653.1	BAE25146.1	C57BL/6J
mRNA	AY324648.1	AAP88590.1	ICR
mRNA	BC003817.1	AAH03817.1	CZECHII
mRNA	M29464.1	AAA39903.1