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Pdcd4 programmed cell death 4 [ Mus musculus (house mouse) ]

Gene ID: 18569, updated on 28-May-2016
Official Symbol
Pdcd4provided by MGI
Official Full Name
programmed cell death 4provided by MGI
Primary source
MGI:MGI:107490
See related
Ensembl:ENSMUSG00000024975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ma3; Tis; D19Ucla1
Orthologs
Location:
19 D2; 19 48.73 cM
Exon count:
16
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 19 NC_000085.6 (53892231..53929861)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (53966721..54004351)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 20 Neighboring gene predicted gene 16299 Neighboring gene predicted gene, 41863 Neighboring gene predicted gene, 30990 Neighboring gene BBSome interacting protein 1 Neighboring gene soc-2 (suppressor of clear) homolog (C. elegans) Neighboring gene predicted gene, 41864 Neighboring gene adrenergic receptor, alpha 2a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • PI3K/Akt/mTOR signaling pathway, organism-specific biosystem (from LIPID MAPS)
    PI3K/Akt/mTOR signaling pathway, organism-specific biosystem
    PI3K/Akt/mTOR signaling pathway
  • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
    Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
  • Proteoglycans in cancer, conserved biosystem (from KEGG)
    Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell aging ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myofibroblast differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
programmed cell death protein 4
Names
protein MA-3
topoisomerase-inhibitor suppressed protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168491.1NP_001161963.1  programmed cell death protein 4

    See identical proteins and their annotated locations for NP_001161963.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC117612
    Consensus CDS
    CCDS29903.1
    UniProtKB/Swiss-Prot
    Q61823
    Related
    ENSMUSP00000025931, ENSMUST00000025931
    Conserved Domains (1) summary
    smart00544
    Location:327440
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
  2. NM_001168492.1NP_001161964.1  programmed cell death protein 4

    See identical proteins and their annotated locations for NP_001161964.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 3' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC117612, BC055739
    Consensus CDS
    CCDS29903.1
    UniProtKB/Swiss-Prot
    Q61823
    Related
    ENSMUSP00000133135, ENSMUST00000165617
    Conserved Domains (1) summary
    smart00544
    Location:327440
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
  3. NM_011050.4NP_035180.2  programmed cell death protein 4

    See identical proteins and their annotated locations for NP_035180.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC117612, AK134366
    Consensus CDS
    CCDS29903.1
    UniProtKB/Swiss-Prot
    Q61823
    Related
    ENSMUSP00000073975, ENSMUST00000074371
    Conserved Domains (1) summary
    smart00544
    Location:327440
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p3 C57BL/6J

    Range
    53892231..53929861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247164.1XP_011245466.1  

    See identical proteins and their annotated locations for XP_011245466.1

    UniProtKB/Swiss-Prot
    Q61823
    Conserved Domains (1) summary
    smart00544
    Location:327440
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
  2. XM_011247163.1XP_011245465.1  

    See identical proteins and their annotated locations for XP_011245465.1

    UniProtKB/Swiss-Prot
    Q61823
    Conserved Domains (1) summary
    smart00544
    Location:327440
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
  3. XM_006526762.2XP_006526825.1  

    See identical proteins and their annotated locations for XP_006526825.1

    UniProtKB/Swiss-Prot
    Q61823
    Conserved Domains (1) summary
    smart00544
    Location:327440
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins

Alternate Mm_Celera

Genomic

  1. AC_000041.1 Alternate Mm_Celera

    Range
    56087143..56124829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)