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Kat2b K(lysine) acetyltransferase 2B [ Mus musculus (house mouse) ]

Gene ID: 18519, updated on 21-May-2016
Official Symbol
Kat2bprovided by MGI
Official Full Name
K(lysine) acetyltransferase 2Bprovided by MGI
Primary source
MGI:MGI:1343094
See related
Ensembl:ENSMUSG00000000708 Vega:OTTMUSG00000035538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pcaf; p/CAF; AI461839; AW536563; A930006P13Rik
Orthologs
Location:
17 C; 17 27.86 cM
Exon count:
20
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 17 NC_000083.6 (53566853..53672721)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (53706640..53812045)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene tumor protein, translationally-controlled, pseudogene 7 Neighboring gene RAB5A, member RAS oncogene family Neighboring gene protein phosphatase 2C-like domain containing 1 Neighboring gene shugoshin-like 1 (S. pombe) Neighboring gene predicted gene, 31532 Neighboring gene RAB5A, member RAS oncogene family, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
acetyltransferase activity EXP
Inferred from Experiment
more info
PubMed 
acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA
Inferred from Direct Assay
more info
PubMed 
lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
transcription cofactor activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring acyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
N-terminal peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
histone H3 acetylation ISO
Inferred from Sequence Orthology
more info
 
histone H3-K9 acetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
internal peptidyl-lysine acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
internal peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chromatin binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of histone H3-K14 acetylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of histone H3-K9 acetylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of vasodilation ISO
Inferred from Sequence Orthology
more info
 
protein acetylation ISO
Inferred from Sequence Orthology
more info
 
protein acetylation TAS
Traceable Author Statement
more info
PubMed 
regulation of protein ADP-ribosylation ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
A band IDA
Inferred from Direct Assay
more info
PubMed 
Ada2/Gcn5/Ada3 transcription activator complex IDA
Inferred from Direct Assay
more info
PubMed 
Ada2/Gcn5/Ada3 transcription activator complex ISO
Inferred from Sequence Orthology
more info
 
I band IDA
Inferred from Direct Assay
more info
PubMed 
actomyosin IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
histone acetyltransferase KAT2B
Names
histone acetylase PCAF
histone acetyltransferase PCAF
lysine acetyltransferase 2B
p300/CBP-associated factor
NP_001177775.1
NP_064389.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190846.1NP_001177775.1  histone acetyltransferase KAT2B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and uses an alternate start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC140263, AK030070
    Conserved Domains (4) summary
    cd05509
    Location:630729
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam06466
    Location:6231
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    cd04301
    Location:449505
    NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
    COG5076
    Location:390729
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
  2. NM_020005.4NP_064389.2  histone acetyltransferase KAT2B isoform 1

    See identical proteins and their annotated locations for NP_064389.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC131785, AC140263, BC082581
    Consensus CDS
    CCDS28880.1
    UniProtKB/Swiss-Prot
    Q9JHD1
    UniProtKB/TrEMBL
    B2RR30
    Related
    ENSMUSP00000000724, OTTMUSP00000050078, ENSMUST00000000724, OTTMUST00000091026
    Conserved Domains (4) summary
    cd05509
    Location:708807
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam06466
    Location:56309
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    cd04301
    Location:527583
    NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
    COG5076
    Location:468807
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p3 C57BL/6J

    Range
    53566853..53672721
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523820.2XP_006523883.1  

    Conserved Domains (4) summary
    cd05509
    Location:569668
    Bromo_gcn5_like; Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long ...
    pfam06466
    Location:1170
    PCAF_N; PCAF (P300/CBP-associated factor) N-terminal domain
    cd04301
    Location:388444
    NAT_SF; N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate
    COG5076
    Location:329668
    COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

RNA

  1. XR_385299.1 RNA Sequence

  2. XR_385300.1 RNA Sequence

Alternate Mm_Celera

Genomic

  1. AC_000039.1 Alternate Mm_Celera

    Range
    57012177..57114622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)