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AGTR1 angiotensin II receptor, type 1 [ Homo sapiens (human) ]

Gene ID: 185, updated on 1-Mar-2015
Official Symbol
AGTR1provided by HGNC
Official Full Name
angiotensin II receptor, type 1provided by HGNC
Primary source
HGNC:HGNC:336
See related
Ensembl:ENSG00000144891; HPRD:00107; MIM:106165; Vega:OTTHUMG00000159503
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B
Summary
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
Orthologs
See AGTR1 in MapViewer
Location:
3q24
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (148697871..148743003)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (148415658..148460790)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 20 Neighboring gene ribosomal protein L38 pseudogene 1 Neighboring gene high mobility group box 1 pseudogene 30 Neighboring gene carboxypeptidase B1 (tissue) Neighboring gene carboxypeptidase A3 (mast cell)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
angiotensin type I receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
angiotensin type I receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
angiotensin type II receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
bradykinin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
angiotensin-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
low-density lipoprotein particle remodeling NAS
Non-traceable Author Statement
more info
PubMed 
phospholipase C-activating G-protein coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
phospholipase C-activating angiotensin-activated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NAD(P)H oxidase activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cellular protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cholesterol esterification IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of inflammatory response TAS
Traceable Author Statement
more info
PubMed 
positive regulation of macrophage derived foam cell differentiation IC
Inferred by Curator
more info
PubMed 
positive regulation of phospholipase A2 activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of reactive oxygen species metabolic process TAS
Traceable Author Statement
more info
PubMed 
regulation of blood vessel size by renin-angiotensin IC
Inferred by Curator
more info
PubMed 
regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of inflammatory response IC
Inferred by Curator
more info
PubMed 
regulation of renal sodium excretion NAS
Non-traceable Author Statement
more info
PubMed 
regulation of systemic arterial blood pressure by renin-angiotensin IC
Inferred by Curator
more info
PubMed 
regulation of vasoconstriction IC
Inferred by Curator
more info
PubMed 
regulation of vasoconstriction IDA
Inferred from Direct Assay
more info
PubMed 
regulation of vasoconstriction NAS
Non-traceable Author Statement
more info
PubMed 
regulation of vasodilation IC
Inferred by Curator
more info
PubMed 
renin-angiotensin regulation of aldosterone production NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of plasma membrane IC
Inferred by Curator
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
type-1 angiotensin II receptor
Names
type-1 angiotensin II receptor
type-1B angiotensin II receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008468.1 RefSeqGene

    Range
    5001..50133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000685.4NP_000676.1  type-1 angiotensin II receptor isoform 1

    See proteins identical to NP_000676.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as pC2, hAT1R-B (PubMed ID:16504375) or hAT1R-C (PubMed ID:11158334), encodes the predominant isoform (1). Variants 1 and 2 encode the same isoform 1.
    Source sequence(s)
    AC024897, AI240900
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    P30556
    UniProtKB/TrEMBL
    Q53YY0
    Related
    ENSP00000273430, OTTHUMP00000215600, ENST00000349243, OTTHUMT00000355806
    Conserved Domains (2) summary
    pfam00001
    Location:51302
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10328
    Location:37156
    7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
  2. NM_004835.4NP_004826.5  type-1 angiotensin II receptor isoform 2

    See proteins identical to NP_004826.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as hAT1R-B (PubMed ID:11158334) or hAT1R-C (PubMed ID:16504375), has an alternate exon in the 5' region, which contains an in-frame AUG start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform 2.
    Source sequence(s)
    AC024897, AI016286, AV651073, BC022447, DA649921
    UniProtKB/TrEMBL
    D3DNG8
    UniProtKB/Swiss-Prot
    P30556
    Related
    ENSP00000398832, ENST00000418473
    Conserved Domains (2) summary
    pfam00001
    Location:86337
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10328
    Location:72297
    7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
  3. NM_009585.3NP_033611.1  type-1 angiotensin II receptor isoform 1

    See proteins identical to NP_033611.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as pC1 or hAT1R-A, lacks an exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC024897, AI240900
    Consensus CDS
    CCDS3137.1
    UniProtKB/Swiss-Prot
    P30556
    UniProtKB/TrEMBL
    Q53YY0
    Related
    ENSP00000419422, OTTHUMP00000215601, ENST00000497524, OTTHUMT00000355807
    Conserved Domains (2) summary
    pfam00001
    Location:51302
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10328
    Location:37156
    7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
  4. NM_031850.3NP_114038.4  type-1 angiotensin II receptor isoform 2

    See proteins identical to NP_114038.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as pC3 or hAT1R-D, has an additional exon in the 5' region, which contains an in-frame AUG start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1. Variants 3 and 4 encode the same isoform 2.
    Source sequence(s)
    AC024897, AI016286, AV651073, BC068494, DA649921
    UniProtKB/TrEMBL
    D3DNG8
    UniProtKB/TrEMBL
    Q6NUP5
    Conserved Domains (2) summary
    pfam00001
    Location:86337
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10328
    Location:72297
    7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx
  5. NM_032049.3NP_114438.2  type-1 angiotensin II receptor isoform 3

    See proteins identical to NP_114438.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as pC4, has two additional exons in the 5' region, but its 5' UTR end has not been determined, compared to variant 1. The resulting isoform (3) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AC024897, AI016286
    UniProtKB/TrEMBL
    A0A0A0MSE3
    Conserved Domains (2) summary
    pfam00001
    Location:80331
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10328
    Location:66185
    7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38 Primary Assembly

    Range
    148697871..148743003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    148378782..148423918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000135.1 Alternate HuRef

    Range
    145788031..145833163
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)