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Osm oncostatin M [ Mus musculus (house mouse) ]

Gene ID: 18413, updated on 30-May-2016
Official Symbol
Osmprovided by MGI
Official Full Name
oncostatin Mprovided by MGI
Primary source
MGI:MGI:104749
See related
Ensembl:ENSMUSG00000058755 Vega:OTTMUSG00000005054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OncoM
Orthologs
Location:
11 A1; 11 2.94 cM
Exon count:
4
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 11 NC_000077.6 (4236785..4241026)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (4136788..4141029)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene GATS protein-like 3 Neighboring gene predicted gene 11956 Neighboring gene predicted gene, 34834 Neighboring gene leukemia inhibitory factor

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
oncostatin-M receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of hormone secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of meiotic nuclear division IDA
Inferred from Direct Assay
more info
PubMed 
oncostatin-M-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein ISO
Inferred from Sequence Orthology
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
response to heat IMP
Inferred from Mutant Phenotype
more info
PubMed 
tyrosine phosphorylation of Stat1 protein IDA
Inferred from Direct Assay
more info
PubMed 
tyrosine phosphorylation of Stat3 protein IDA
Inferred from Direct Assay
more info
PubMed 
tyrosine phosphorylation of Stat5 protein IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013365.2NP_001013383.1  oncostatin-M precursor

    See identical proteins and their annotated locations for NP_001013383.1

    Status: VALIDATED

    Source sequence(s)
    AL807825
    Consensus CDS
    CCDS24382.1
    UniProtKB/Swiss-Prot
    P53347
    Related
    ENSMUSP00000074708, OTTMUSP00000005249, ENSMUST00000075221, OTTMUST00000011263
    Conserved Domains (2) summary
    pfam01291
    Location:43194
    LIF_OSM; LIF / OSM family
    pfam02956
    Location:191249
    TT_ORF1; TT viral orf 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p3 C57BL/6J

    Range
    4236785..4241026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243671.1XP_011241973.1  

    Conserved Domains (2) summary
    pfam01291
    Location:23174
    LIF_OSM; LIF / OSM family
    pfam02956
    Location:171229
    TT_ORF1; TT viral orf 1

Alternate Mm_Celera

Genomic

  1. AC_000033.1 Alternate Mm_Celera

    Range
    4735950..4740191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)