U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc22a18 solute carrier family 22 (organic cation transporter), member 18 [ Mus musculus (house mouse) ]

Gene ID: 18400, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Slc22a18provided by MGI
Official Full Name
solute carrier family 22 (organic cation transporter), member 18provided by MGI
Primary source
MGI:MGI:1336884
See related
Ensembl:ENSMUSG00000000154 AllianceGenome:MGI:1336884
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HET; ITM; BWR1A; Impt1; TSSC5; Orctl2; BWSCR1A; Slc22a1l; p45-BWR1A
Summary
Predicted to enable transmembrane transporter activity and ubiquitin protein ligase binding activity. Predicted to be involved in xenobiotic detoxification by transmembrane export across the plasma membrane. Predicted to act upstream of or within anion transport. Predicted to be located in apical plasma membrane; cytoplasm; and nuclear envelope. Predicted to be integral component of plasma membrane. Is expressed in several structures, including liver; metanephros; nervous system; placenta; and yolk sac. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human SLC22A18 (solute carrier family 22 member 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 388.3), duodenum adult (RPKM 122.8) and 5 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7 F5; 7 88.22 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143027502..143053071)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143473726..143499334)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase inhibitor 1C Neighboring gene predicted gene, 33663 Neighboring gene pleckstrin homology like domain, family A, member 2 Neighboring gene nucleosome assembly protein 1-like 4 Neighboring gene predicted gene, 23297

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Impaired expression of an organic cation transporter, IMPT1, in a knockout mouse model for kidney stone disease. Tzortzaki EG, et al. Urol Res, 2003 Aug. PMID 12856169
  2. A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice. Morisaki H, et al. DNA Res, 1998 Aug 31. PMID 9802569
  3. Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. Cooper PR, et al. Genomics, 1998 Apr 1. PMID 9570947
  4. IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes. Dao D, et al. Hum Mol Genet, 1998 Apr. PMID 9499412
  5. Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndrome. Singh VB, et al. Development, 2017 May 15. PMID 28428215, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Slc22a18/Itm gene is imprinted, with preferential expression from the maternal allele in fetal, newborn and most adult tissues, but biallelic expression in adult kidney and liver.
    Title: A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice.
  2. decreased IMPT1 mRNA expression may contribute to the impaired renal function in APRT-deficient male mice
    Title: Impaired expression of an organic cation transporter, IMPT1, in a knockout mouse model for kidney stone disease.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables organic anion transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic anion transport TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
solute carrier family 22 member 18
Names
ORCTL-2
imprinted multi-membrane spanning polyspecific transporter-related protein 1
organic cationic transporter-like 2
tumor suppressing subtransferable candidate 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042760.2 → NP_001036225.1  solute carrier family 22 member 18 isoform b

    See identical proteins and their annotated locations for NP_001036225.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' non-coding exon; hence, differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (b).
    Source sequence(s)
    AB012084, BU758157
    Consensus CDS
    CCDS22041.1
    UniProtKB/Swiss-Prot
    O35428, O54959, O88283, Q78KK3, Q99NF4
    UniProtKB/TrEMBL
    A0A0R4J0P7
    Related
    ENSMUSP00000101537.3, ENSMUST00000105917.3
    Conserved Domains (2) summary
    cd06174
    Location:14 → 378
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:14 → 367
    MFS_1; Major Facilitator Superfamily

  2. NM_001417039.1 → NP_001403968.1  solute carrier family 22 member 18 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC023248

  3. NM_001417040.1 → NP_001403969.1  solute carrier family 22 member 18 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC023248

  4. NM_001417041.1 → NP_001403970.1  solute carrier family 22 member 18 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC023248

  5. NM_008767.3 → NP_032793.2  solute carrier family 22 member 18 isoform b

    See identical proteins and their annotated locations for NP_032793.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same isoform (b).
    Source sequence(s)
    AK002460, BB869719, BE865039, BU758157
    Consensus CDS
    CCDS22041.1
    UniProtKB/Swiss-Prot
    O35428, O54959, O88283, Q78KK3, Q99NF4
    UniProtKB/TrEMBL
    A0A0R4J0P7
    Related
    ENSMUSP00000056082.6, ENSMUST00000052348.12
    Conserved Domains (2) summary
    cd06174
    Location:14 → 378
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:14 → 367
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    143027502..143053071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508514.4 → XP_006508577.1  solute carrier family 22 member 18 isoform X4

    UniProtKB/TrEMBL
    Q05DG8
    Conserved Domains (1) summary
    cl28910
    Location:1 → 271
    MFS; Major Facilitator Superfamily

  2. XM_006508513.3 → XP_006508576.1  solute carrier family 22 member 18 isoform X3

    UniProtKB/TrEMBL
    Q05DG8
    Conserved Domains (1) summary
    cl28910
    Location:1 → 279
    MFS; Major Facilitator Superfamily

  3. XM_006508511.3 → XP_006508574.1  solute carrier family 22 member 18 isoform X1

    See identical proteins and their annotated locations for XP_006508574.1

    UniProtKB/Swiss-Prot
    O35428, O54959, O88283, Q78KK3, Q99NF4
    Conserved Domains (1) summary
    cd17331
    Location:13 → 396
    MFS_SLC22A18; Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters

  4. XM_006508512.3 → XP_006508575.1  solute carrier family 22 member 18 isoform X2

    UniProtKB/Swiss-Prot
    O35428, O54959, O88283, Q78KK3, Q99NF4
    Conserved Domains (1) summary
    cd17331
    Location:7 → 366
    MFS_SLC22A18; Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q78KK3.2 GenPept UniProtKB/Swiss-Prot:Q78KK3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous