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Oprl1 opioid receptor-like 1 [ Mus musculus (house mouse) ]

Gene ID: 18389, updated on 24-May-2016
Official Symbol
Oprl1provided by MGI
Official Full Name
opioid receptor-like 1provided by MGI
Primary source
MGI:MGI:97440
See related
Ensembl:ENSMUSG00000027584 Vega:OTTMUSG00000016806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KOR3; ORGC; ORL1; Oprl; XOR1; morc; KOR-3; LC132; MOR-C
Summary
The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jan 2016]
Orthologs
Location:
2 103.74 cM; 2 H2-4
Exon count:
7
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (181714806..181720985)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (181449749..181455677)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signaling 19 Neighboring gene LKAAEAR motif containing 1 (IKAAEAR murine motif) Neighboring gene neuropeptides B/W receptor 2 pseudogene Neighboring gene myelin transcription factor 1 Neighboring gene DnaJ (Hsp40) homolog, subfamily A, member 1 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
nociceptin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
nociceptin receptor activity ISO
Inferred from Sequence Orthology
more info
 
opioid receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
 
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
behavior IEA
Inferred from Electronic Annotation
more info
 
eating behavior ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gastric acid secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
positive regulation of urine volume ISO
Inferred from Sequence Orthology
more info
 
regulation of cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of locomotor rhythm ISO
Inferred from Sequence Orthology
more info
 
regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
nociceptin receptor
Names
K3 opiate receptor
N/OFQ receptor
kappa-type 3 opioid receptor
nociceptin/ orphaninFQ receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252565.1NP_001239494.1  nociceptin receptor isoform 1

    See identical proteins and their annotated locations for NP_001239494.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' non-coding exon; therefore, differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK038620, AL845173
    Consensus CDS
    CCDS17222.1
    UniProtKB/Swiss-Prot
    P35377
    UniProtKB/TrEMBL
    Q542U1
    Related
    ENSMUSP00000104399, OTTMUSP00000018252, ENSMUST00000108768, OTTMUST00000040817
    Conserved Domains (2) summary
    pfam00001
    Location:71316
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:58175
    7tm_4; Olfactory receptor
  2. NM_001318919.1NP_001305848.1  nociceptin receptor isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon (nt 1349-1351), while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon (nt 1436-1438). This RefSeq represents the longer, C-terminally extended isoform. As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    AL845173, BC050885, BY267034
    UniProtKB/Swiss-Prot
    P35377
    Conserved Domains (2) summary
    pfam00001
    Location:71316
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:58175
    7tm_4; Olfactory receptor
  3. NM_001318920.1NP_001305849.1  nociceptin receptor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as KOR-3d) uses an alternate, in-frame donor splice site at the first coding exon compared to variant 1. The resulting isoform (2) is shorter, missing a 5 aa protein segment compared to isoform 1.
    Source sequence(s)
    AF126469, AL845173, BC050885
    UniProtKB/Swiss-Prot
    P35377
    Conserved Domains (1) summary
    pfam00001
    Location:68311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. NM_001318922.1NP_001305851.1  nociceptin receptor isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as KOR-3a) contains an additional internal exon, which results in translation initiation from an alternate start codon compared to variant 1. The encoded isoform (3) is shorter with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK043275, AL845173, BY267034
    UniProtKB/TrEMBL
    B0R0C0
    Conserved Domains (1) summary
    pfam00001
    Location:60302
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  5. NM_001318923.1NP_001305852.1  nociceptin receptor isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate donor splice site and contains an additional internal exon, which results in translation initiation from an alternate start codon compared to variant 1. The encoded isoform (4) is shorter with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK044178, AL845173, BY267034
    Conserved Domains (1) summary
    pfam00001
    Location:55297
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  6. NM_001318924.1NP_001305853.1  nociceptin receptor isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as KOR-3b) contains an additional internal exon, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus compared to isoform 1. Variants 6 and 7 encode the same isoform.
    Source sequence(s)
    AK031926, AL845173, BU708032
    Conserved Domains (1) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  7. NM_001318925.1NP_001305854.1  nociceptin receptor isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also known as KOR-3c) contains an additional internal exon, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus compared to isoform 1. Variants 6 and 7 encode the same isoform.
    Source sequence(s)
    AK031926, AL845173, BY267034
    Conserved Domains (1) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  8. NM_011012.5NP_035142.1  nociceptin receptor isoform 1

    See identical proteins and their annotated locations for NP_035142.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon (nt 1349-1351), while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon (nt 1436-1438). This RefSeq represents the shorter isoform. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AL845173, BC050885, BY267034
    Consensus CDS
    CCDS17222.1
    UniProtKB/Swiss-Prot
    P35377
    UniProtKB/TrEMBL
    Q542U1
    Related
    ENSMUSP00000071513, OTTMUSP00000018249, ENSMUST00000071585, OTTMUST00000040810
    Conserved Domains (2) summary
    pfam00001
    Location:71316
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:58175
    7tm_4; Olfactory receptor

RNA

  1. NR_134926.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks two consecutive internal exons compared to variant 1. It is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AK142474, AL845173, BY267034

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    181714806..181720985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239933.1XP_011238235.1  

  2. XM_006500582.1XP_006500645.1  

    See identical proteins and their annotated locations for XP_006500645.1

    UniProtKB/Swiss-Prot
    P35377
    Conserved Domains (1) summary
    pfam00001
    Location:68311
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_006500584.1XP_006500647.1  

    Conserved Domains (1) summary
    pfam00001
    Location:1238
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    185797608..185803583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)