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Oprk1 opioid receptor, kappa 1 [ Mus musculus (house mouse) ]

Gene ID: 18387, updated on 29-May-2016
Official Symbol
Oprk1provided by MGI
Official Full Name
opioid receptor, kappa 1provided by MGI
Primary source
MGI:MGI:97439
See related
Ensembl:ENSMUSG00000025905 Vega:OTTMUSG00000034734
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
Summary
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jan 2016]
Orthologs
Location:
1 1.89 cM; 1 A2-A3
Exon count:
4
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 1 NC_000067.6 (5588450..5606134)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (5578574..5592947)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide pseudogene Neighboring gene proteasome (prosome, macropain) subunit, alpha type 7 pseudogene Neighboring gene neuropeptides B/W receptor 1 Neighboring gene COP9 (constitutive photomorphogenic) homolog, subunit 2 pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC151172

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
dynorphin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
dynorphin receptor activity ISO
Inferred from Sequence Orthology
more info
 
neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
opioid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
opioid receptor activity ISO
Inferred from Sequence Orthology
more info
 
opioid receptor activity TAS
Traceable Author Statement
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
 
adenylate cyclase-inhibiting opioid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
behavior IEA
Inferred from Electronic Annotation
more info
 
behavioral response to cocaine ISO
Inferred from Sequence Orthology
more info
 
conditioned place preference ISO
Inferred from Sequence Orthology
more info
 
defense response to virus ISO
Inferred from Sequence Orthology
more info
 
eating behavior ISO
Inferred from Sequence Orthology
more info
 
immune response ISO
Inferred from Sequence Orthology
more info
 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
maternal behavior ISO
Inferred from Sequence Orthology
more info
 
negative regulation of luteinizing hormone secretion ISO
Inferred from Sequence Orthology
more info
 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
opioid receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
phospholipase C-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of locomotion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
regulation of aerobic respiration ISO
Inferred from Sequence Orthology
more info
 
regulation of energy homeostasis ISO
Inferred from Sequence Orthology
more info
 
regulation of saliva secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
response to insulin ISO
Inferred from Sequence Orthology
more info
 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of temperature stimulus ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
axon terminus ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
kappa-type opioid receptor
Names
opioid receptor, kappa 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204371.1NP_001191300.1  kappa-type opioid receptor isoform 1

    See identical proteins and their annotated locations for NP_001191300.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon (nt 1356-1358), while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon (nt 1443-1445). This RefSeq represents the shorter isoform. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC124029, AK136866, BB079154, L11065, S81111
    Consensus CDS
    CCDS14809.1
    UniProtKB/Swiss-Prot
    P33534
    UniProtKB/TrEMBL
    Q14AL5, Q3UVW8
    Related
    ENSMUSP00000027038, OTTMUSP00000048084, ENSMUST00000027038, OTTMUST00000088256
    Conserved Domains (2) summary
    pfam00001
    Location:82330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:70312
    7tm_4; Olfactory receptor
  2. NM_001318735.1NP_001305664.1  kappa-type opioid receptor isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon (nt 1356-1358), while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon (nt 1443-1445). This RefSeq represents the longer, C-terminally extended isoform. As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    AC124029, AK136866, BB079154, L11065, S81111
    UniProtKB/Swiss-Prot
    P33534
    UniProtKB/TrEMBL
    Q3UVW8
    Conserved Domains (2) summary
    pfam00001
    Location:82330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:70312
    7tm_4; Olfactory receptor
  3. NM_011011.2NP_035141.1  kappa-type opioid receptor isoform 1

    See identical proteins and their annotated locations for NP_035141.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 5' non-coding region and has a shorter 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC124029, AK136866, BB079154, L11065
    Consensus CDS
    CCDS14809.1
    UniProtKB/Swiss-Prot
    P33534
    UniProtKB/TrEMBL
    Q14AL5, Q3UVW8
    Related
    ENSMUSP00000125105, OTTMUSP00000048083, ENSMUST00000160777, OTTMUST00000088255
    Conserved Domains (2) summary
    pfam00001
    Location:82330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:70312
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p3 C57BL/6J

    Range
    5588450..5606134
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495470.1XP_006495533.1  

    Conserved Domains (2) summary
    pfam00001
    Location:1241
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:24219
    7tm_4; Olfactory receptor

Alternate Mm_Celera

Genomic

  1. AC_000023.1 Alternate Mm_Celera

    Range
    5572638..5590274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)