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DTNA dystrobrevin alpha [ Homo sapiens (human) ]

Gene ID: 1837, updated on 8-May-2016
Official Symbol
DTNAprovided by HGNC
Official Full Name
dystrobrevin alphaprovided by HGNC
Primary source
HGNC:HGNC:3057
See related
Ensembl:ENSG00000134769 HPRD:03141; MIM:601239; Vega:OTTHUMG00000132309
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DTN; DRP3; DTN-A; LVNC1; D18S892E
Summary
The protein encoded by this gene belongs to the dystrobrevin subfamily of the dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Mutations in this gene are associated with left ventricular noncompaction with congenital heart defects. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
18q12
Exon count:
32
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 18 NC_000018.10 (34493290..34891844)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (32073254..32471808)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene additional sex combs like 3, transcriptional regulator Neighboring gene uncharacterized LOC105372060 Neighboring gene nucleolar protein 4 Neighboring gene ribosomal protein L10a pseudogene 13 Neighboring gene uncharacterized LOC105372062 Neighboring gene uncharacterized LOC105372061 Neighboring gene uncharacterized LOC101927757 Neighboring gene microtubule associated protein RP/EB family member 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of dystrobrevin, alpha (DTNA) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ96209

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PDZ domain binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
neuromuscular synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
striated muscle contraction TAS
Traceable Author Statement
more info
PubMed 
synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
sarcolemma IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
dystrobrevin alpha
Names
dystrobrevin, alpha
dystrophin-related protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009201.1 RefSeqGene

    Range
    5001..403555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001128175.1NP_001121647.1  dystrobrevin alpha isoform 9

    See identical proteins and their annotated locations for NP_001121647.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an internal coding exon and multiple exons from the 3' end, and contains an alternate 3' exon, compared to variant 1. The resulting isoform (9) lacks an internal segment and has a much shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AI368045, BC005300, DA197970
    Consensus CDS
    CCDS56060.1
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000451516, OTTHUMP00000245175, ENST00000554864, OTTHUMT00000411816
    Conserved Domains (3) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
  2. NM_001198938.1NP_001185867.1  dystrobrevin alpha isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the CDS and 3' UTR compared to variant 1. The resulting isoform (10) is shorter; it lacks two internal segments and has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB209102, AK308410, BC005300, BC033969, BX103860, CF457303, DA197970
    Consensus CDS
    CCDS59312.1
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000470152, OTTHUMP00000269263, ENST00000598334, OTTHUMT00000461196
    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    cl12057
    Location:416486
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  3. NM_001198939.1NP_001185868.1  dystrobrevin alpha isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the CDS compared to variant 1. The resulting isoform (11) lacks two internal segments but has an extra segment in a downstream region, compared to isoform 1.
    Source sequence(s)
    AC068506, AL833285, BC005300, DA197970
    Consensus CDS
    CCDS56061.1
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000382072, OTTHUMP00000163151, ENST00000399121, OTTHUMT00000255418
    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:413502
    YlqD; YlqD protein
  4. NM_001198940.1NP_001185869.1  dystrobrevin alpha isoform 12

    See identical proteins and their annotated locations for NP_001185869.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the CDS compared to variant 1. The resulting isoform (12) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AB209102, AC068506, DA197970
    Consensus CDS
    CCDS59311.1
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000473078, OTTHUMP00000269264, ENST00000595022, OTTHUMT00000461197
    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    cl12057
    Location:416486
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  5. NM_001198941.1NP_001185870.1  dystrobrevin alpha isoform 13

    See identical proteins and their annotated locations for NP_001185870.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the CDS, lacks multiple exons from the 3' UTR and contains an alternate 3' exon compared to variant 1. The resulting isoform (13) lacks two internal segments and has a much shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC068506, AK291156, DA398530
    Consensus CDS
    CCDS59310.1
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000473119, OTTHUMP00000269267, ENST00000597599, OTTHUMT00000461200
    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:413501
    YlqD; YlqD protein
  6. NM_001198942.1NP_001185871.1  dystrobrevin alpha isoform 14

    See identical proteins and their annotated locations for NP_001185871.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) lacks multiple exons from the 5' end, contains an alternate 5' exon, and differs in the CDS compared to variant 1. The resulting isoform (14) has a much shorter N-terminus, lacks an internal segment in one region and contains an extra segment in a different region, compared to isoform 1.
    Source sequence(s)
    AC068506, AK295732, DN991561
    Consensus CDS
    CCDS56062.1
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000269192, OTTHUMP00000245177, ENST00000269192, OTTHUMT00000411818
    Conserved Domains (1) summary
    cl12057
    Location:185255
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  7. NM_001198943.1NP_001185872.1  dystrobrevin alpha isoform 15

    See identical proteins and their annotated locations for NP_001185872.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) lacks multiple exons from the 5' end, contains an alternate 5' UTR, and differs in the CDS compared to variant 1. The resulting isoform (15) has a much shorter N-terminus and lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC068506, AK296450
    UniProtKB/TrEMBL
    B7Z3X3
    Related
    ENSP00000470247, OTTHUMP00000269268, ENST00000601125, OTTHUMT00000461201
    Conserved Domains (2) summary
    cd02334
    Location:139
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    cl12057
    Location:166236
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  8. NM_001198944.1NP_001185873.1  dystrobrevin alpha isoform 16

    See identical proteins and their annotated locations for NP_001185873.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) lacks multiple exons from the 5' end, contains an alternate 5' exon, and differs in the CDS compared to variant 1. The resulting isoform (16) has a much shorter N-terminus and lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC068506, AK295789, DN991561
    Consensus CDS
    CCDS56063.1
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000452255, OTTHUMP00000245178, ENST00000556414, OTTHUMT00000411819
    Conserved Domains (1) summary
    cl12057
    Location:128198
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  9. NM_001198945.1NP_001185874.1  dystrobrevin alpha isoform 17

    See identical proteins and their annotated locations for NP_001185874.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) lacks multiple exons in the middle region and from the 3' end, and contains an alternate 3' exon compared to variant 1. The resulting isoform (17) lacks a large internal segment and has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC068506, AK294746, DA073612, R45531
    Consensus CDS
    CCDS59313.1
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000469121, OTTHUMP00000269262, ENST00000596745, OTTHUMT00000461195
    Conserved Domains (3) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    pfam09069
    Location:144199
    EF-hand_3; EF-hand
    pfam13874
    Location:219306
    Nup54; Nucleoporin complex subunit 54
  10. NM_001390.4NP_001381.2  dystrobrevin alpha isoform 1

    See identical proteins and their annotated locations for NP_001381.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as DTN1, encodes the longest isoform (1). Its 5' UTR has not been determined.
    Source sequence(s)
    AB209102, AL833285, BC005300, BC033969, BX103860, U26742, U46745
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000405819, ENST00000444659
    Conserved Domains (5) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam15376
    Location:297393
    DUF4603; Domain of unknown function (DUF4603)
    cl12057
    Location:476546
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  11. NM_001391.5NP_001382.2  dystrobrevin alpha isoform 3

    See identical proteins and their annotated locations for NP_001382.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as DTN2, lacks multiple exons from the 3' end and contains an alternate 3' exon, compared to transcript variant 1. This results in a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC068506, AI670964, BC005300, R45531, U26742, U26743, U46745
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Conserved Domains (5) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:473561
    YlqD; YlqD protein
    pfam15376
    Location:297393
    DUF4603; Domain of unknown function (DUF4603)
  12. NM_001392.4NP_001383.2  dystrobrevin alpha isoform 7

    See identical proteins and their annotated locations for NP_001383.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), also known as DTN3 or delta transcript, lacks multiple exons from the 3' end and contains an alternate 3' exon, compared to transcript variant 1. This results in a shorter isoform (7) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC005300, DA073612, U26742
    Consensus CDS
    CCDS42426.1
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000322519, OTTHUMP00000163154, ENST00000315456, OTTHUMT00000255421
    Conserved Domains (3) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
  13. NM_032975.3NP_116757.2  dystrobrevin alpha isoform 2

    See identical proteins and their annotated locations for NP_116757.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as alpha transcript, lacks two consecutive in-frame coding exons, compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AB209102, AL833285, BC033969, BX103860, DA073612, U26742
    Consensus CDS
    CCDS45848.1
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000283365, ENST00000283365
    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    cl12057
    Location:419489
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  14. NM_032978.6NP_116760.2  dystrobrevin alpha isoform 4

    See identical proteins and their annotated locations for NP_116760.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as beta transcript, lacks an internal coding exon and multiple exons from the 3' end, and contains an alternate 3' exon, compared to transcript variant 1. This results in a shorter isoform (4) with a distinct C-terminus and missing an internal segment, compared to isoform 1.
    Source sequence(s)
    AC068506, AI670964, AK291156, DA398530, R45531, U26744, U46745
    Consensus CDS
    CCDS11908.1
    UniProtKB/Swiss-Prot
    Q9Y4J8
    UniProtKB/TrEMBL
    A0A024RC32
    Related
    ENSP00000336682, OTTHUMP00000163153, ENST00000348997, OTTHUMT00000255420
    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:470558
    YlqD; YlqD protein
  15. NM_032979.4NP_116761.2  dystrobrevin alpha isoform 5

    See identical proteins and their annotated locations for NP_116761.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), also known as gamma transcript, lacks two consecutive in-frame coding exons and multiple exons from the 3' end, and contains an alternate 3' exon, compared to transcript variant 1. This results in a shorter isoform (5) with a distinct C-terminus and missing an internal segment, compared to isoform 1.
    Source sequence(s)
    AC068506, AI670964, DA073612, R45531, U26742, U26743
    Consensus CDS
    CCDS59309.1
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:416504
    YlqD; YlqD protein
  16. NM_032980.3NP_116762.2  dystrobrevin alpha isoform 6

    See identical proteins and their annotated locations for NP_116762.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), also known as epsilon transcript, lacks two in-frame coding exons and multiple exons from the 5' end, and contains an alternate 5' exon, compared to transcript variant 1. This results in an isoform (6) with a much shorter N-terminus and missing two internal segments, compared to isoform 1.
    Source sequence(s)
    AB209102, AL833285, BC033969, BX103860, DC327958, U46746
    Consensus CDS
    CCDS11909.1
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000467720, OTTHUMP00000163152, ENST00000591182, OTTHUMT00000255419
    Conserved Domains (1) summary
    cl12057
    Location:124194
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  17. NM_032981.4NP_116763.1  dystrobrevin alpha isoform 8

    See identical proteins and their annotated locations for NP_116763.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), also known as zeta transcript, lacks multiple exons from the 5' and 3' ends as well as few internal exons, and contains alternate 5' and 3' exons, compared to transcript variant 1. This results in a shorter isoform (8) with distinct N- and C-termini and lacking two internal segments, compared to isoform 1.
    Source sequence(s)
    AC068506, AI670964, DC327958, R45531, U26743
    Consensus CDS
    CCDS59314.1
    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000471783, OTTHUMP00000269269, ENST00000597674, OTTHUMT00000461204
    Conserved Domains (1) summary
    PRK05431
    Location:98168
    PRK05431; seryl-tRNA synthetase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p2 Primary Assembly

    Range
    34493290..34891844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722396.2XP_006722459.1  

    See identical proteins and their annotated locations for XP_006722459.1

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:503592
    YlqD; YlqD protein
  2. XM_006722406.1XP_006722469.1  

    See identical proteins and their annotated locations for XP_006722469.1

    UniProtKB/Swiss-Prot
    Q9Y4J8
    Conserved Domains (5) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam15376
    Location:297393
    DUF4603; Domain of unknown function (DUF4603)
    cl12057
    Location:476546
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  3. XM_006722402.2XP_006722465.1  

    See identical proteins and their annotated locations for XP_006722465.1

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:503592
    YlqD; YlqD protein
  4. XM_006722403.2XP_006722466.1  

    See identical proteins and their annotated locations for XP_006722466.1

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:503592
    YlqD; YlqD protein
  5. XM_006722395.2XP_006722458.1  

    See identical proteins and their annotated locations for XP_006722458.1

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:503592
    YlqD; YlqD protein
  6. XM_006722404.2XP_006722467.1  

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam13874
    Location:499583
    Nup54; Nucleoporin complex subunit 54
  7. XM_006722399.2XP_006722462.1  

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    cl12057
    Location:506576
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  8. XM_011525852.1XP_011524154.1  

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:502591
    YlqD; YlqD protein
  9. XM_006722401.2XP_006722464.1  

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:472561
    YlqD; YlqD protein
  10. XM_006722405.2XP_006722468.1  

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:446535
    YlqD; YlqD protein
  11. XM_006722400.2XP_006722463.1  

    Conserved Domains (5) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:473562
    YlqD; YlqD protein
    pfam15376
    Location:297393
    DUF4603; Domain of unknown function (DUF4603)
  12. XM_006722407.2XP_006722470.1  

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:416505
    YlqD; YlqD protein
  13. XM_006722408.2XP_006722471.1  

    See identical proteins and their annotated locations for XP_006722471.1

    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000470716, OTTHUMP00000269266, ENST00000598142, OTTHUMT00000461199
    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    cl12057
    Location:419489
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  14. XM_005258207.2XP_005258264.1  

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:500589
    YlqD; YlqD protein
  15. XM_005258216.3XP_005258273.1  

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    cl12057
    Location:503573
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  16. XM_005258217.2XP_005258274.1  

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:443532
    YlqD; YlqD protein
  17. XM_005258221.3XP_005258278.1  

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    cl12057
    Location:446516
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  18. XM_005258218.2XP_005258275.1  

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:442531
    YlqD; YlqD protein
  19. XM_005258219.3XP_005258276.1  

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:470559
    YlqD; YlqD protein
  20. XM_005258212.2XP_005258269.1  

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:470559
    YlqD; YlqD protein
  21. XM_005258222.3XP_005258279.1  

    See identical proteins and their annotated locations for XP_005258279.1

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    cl12057
    Location:442512
    Seryl_tRNA_N; Seryl-tRNA synthetase N-terminal domain
  22. XM_005258220.2XP_005258277.1  

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:413502
    YlqD; YlqD protein
  23. XM_006722409.1XP_006722472.1  

    See identical proteins and their annotated locations for XP_006722472.1

    UniProtKB/Swiss-Prot
    Q9Y4J8
    Conserved Domains (5) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:473561
    YlqD; YlqD protein
    pfam15376
    Location:297393
    DUF4603; Domain of unknown function (DUF4603)
  24. XM_006722410.2XP_006722473.1  

    See identical proteins and their annotated locations for XP_006722473.1

    UniProtKB/Swiss-Prot
    Q9Y4J8
    Related
    ENSP00000472031, OTTHUMP00000269265, ENST00000598774, OTTHUMT00000461198
    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:416504
    YlqD; YlqD protein
  25. XM_005258223.2XP_005258280.1  

    See identical proteins and their annotated locations for XP_005258280.1

    UniProtKB/TrEMBL
    A0A024RC32
    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:470558
    YlqD; YlqD protein
  26. XM_011525853.1XP_011524155.1  

    See identical proteins and their annotated locations for XP_011524155.1

    UniProtKB/Swiss-Prot
    Q9Y4J8
    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:413501
    YlqD; YlqD protein
  27. XM_006722415.1XP_006722478.1  

    See identical proteins and their annotated locations for XP_006722478.1

    UniProtKB/Swiss-Prot
    Q9Y4J8
    Conserved Domains (3) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
  28. XM_006722398.2XP_006722461.1  

    See identical proteins and their annotated locations for XP_006722461.1

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:503592
    YlqD; YlqD protein
  29. XM_011525851.1XP_011524153.1  

    See identical proteins and their annotated locations for XP_011524153.1

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:503592
    YlqD; YlqD protein
  30. XM_006722397.2XP_006722460.1  

    See identical proteins and their annotated locations for XP_006722460.1

    Conserved Domains (4) summary
    pfam09068
    Location:14140
    EF-hand_2; EF hand
    cd02334
    Location:241289
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09069
    Location:144232
    EF-hand_3; EF-hand
    pfam11068
    Location:503592
    YlqD; YlqD protein
  31. XM_006722413.2XP_006722476.1  

    Conserved Domains (1) summary
    pfam11068
    Location:95184
    YlqD; YlqD protein
  32. XM_006722414.2XP_006722477.1  

    Conserved Domains (1) summary
    pfam11068
    Location:94183
    YlqD; YlqD protein
  33. XM_006722412.2XP_006722475.1  

    Conserved Domains (1) summary
    pfam11068
    Location:125214
    YlqD; YlqD protein
  34. XM_006722411.2XP_006722474.1  

    Conserved Domains (1) summary
    pfam11068
    Location:185274
    YlqD; YlqD protein
  35. XM_005258224.2XP_005258281.1  

    Conserved Domains (1) summary
    pfam11068
    Location:182271
    YlqD; YlqD protein

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    32000280..32398881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)