AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) [Homo sapiens] - Gene

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Summary

Official Symbol: AGTprovided by HGNC
Official Full Name: angiotensinogen (serpin peptidase inhibitor, clade A, member 8)provided by HGNC
Primary source: HGNC:333
See related: Ensembl:ENSG00000135744; HPRD:00106; MIM:106150; Vega:OTTHUMG00000037757
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ANHU; SERPINA8; FLJ92595; FLJ97926
Summary: The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 1q42.2

Sequence :: Chromosome: 1; NC_000001.10 (230838269..230850336, complement)

See AGT in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A meta-analysis failed to provide evidence for the genetic association of the AGT gene T174M polymorphism with hypertension risk in the Chinese population.
Title: Association between the angiotensinogen gene T174M polymorphism and hypertension risk in the Chinese population: a meta-analysis.
Suggest epistatic effects of ACE I/D and AGT gene variants on left ventricular mass in hypertensive patients.
Title: Epistatic effects of ACE I/D and AGT gene variants on left ventricular mass in hypertensive patients: the HyperGEN study.
G-6A polymorphism, which modulates the transcriptional activity of the AGT promoter, may contribute to non-familial sick sinus syndrome susceptibility.
Title: Promoter polymorphism G-6A, which modulates angiotensinogen gene expression, is associated with non-familial sick sinus syndrome.
There is a positive association between angiotensinogen gene polymorphisms and haplotypes with essential hypertension.
Title: Hypercontrols in genotype-phenotype analysis reveal ancestral haplotypes associated with essential hypertension.
The results evidence further the independent effects of AGT gene polymorphisms and exposure to occupational noise... Furthermore, the risk of hypertension increased with noise exposure among TT homozygotes but not among those with at least one M allele.
Title: Gene-environment interaction between angiotensinogen and chronic exposure to occupational noise contribute to hypertension.
Local intrarenal renin angiotensin system probably plays an important role in the development of hypertension and proteinuria in renal transplant recipients
Title: Elevated urinary angiotensinogen a marker of intrarenal renin angiotensin system in hypertensive renal transplant recipients: does it play a role in development of proteinuria in hypertensive renal transplant patients?
analysis of angiotensin II-dependent transcriptional activation of human steroidogenic acute regulatory protein gene by a 25-kDa cAMP-responsive element modulator protein isoform and Yin Yang 1
Title: Angiotensin II-dependent transcriptional activation of human steroidogenic acute regulatory protein gene by a 25-kDa cAMP-responsive element modulator protein isoform and Yin Yang 1.
a dominant role of cardiac chymase in the formation of Ang II from Ang-(1-12)
Title: Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue.
The study objective was to examine the association of hypertension in the Lebanese population with three renin-angiotensin system gene polymorphisms (RAS): angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin-receptor type 1 (AT1R).
Title: The association of hypertension with renin-angiotensin system gene polymorphisms in the Lebanese population.
ACE I/D polymorphism II genotype, angiotensinogen M235T polymorphism TT genotype and G allele and GG genotype of angiotensinogen G-6A polymorphism were independently associated with atrial fibrillation.
Title: Polymorphisms of the angiotensin-converting enzyme and angiotensinogen gene in patients with atrial fibrillation.

Submit: New GeneRIF Correction See all (364)

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Phenotypes

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Hypertension, essential, susceptibility to

MIM: 145500

Preeclampsia, susceptibility to

MIM: 106150

Products	Interactant	Other Gene	Source	Pubs	Description
P01019	Q9BYF1	ACE2	HPRD	PubMed
P01019	P01019	AGT	HPRD	PubMed
P01019	P30556	AGTR1	HPRD	PubMed
P01019	P50052	AGTR2	HPRD	PubMed
P01019	P23946	CMA1	HPRD	PubMed
P01019	P08311	CTSG	HPRD	PubMed
P01019	Q9ULA0	DNPEP	HPRD	PubMed
P01019	Q07075	ENPEP	HPRD	PubMed
P01019	Q01844	EWSR1	HPRD	PubMed
P01019	P01042	KNG1	HPRD	PubMed
P01019	P04201	MAS1	HPRD	PubMed
P01019	Q16819	MEP1A	HPRD	PubMed
P01019	P42785	PRCP	HPRD	PubMed
P01019	P48147	PREP	HPRD	PubMed
P01019	P13727	PRG2	HPRD	PubMed
BioGRID:106690	BioGRID:108431	EWSR1	BioGRID	PubMed	Two-hybrid
BioGRID:106690	BioGRID:109142	GRB2	BioGRID	PubMed	Two-hybrid
BioGRID:106690	BioGRID:113010	TP53	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
acetyltransferase activator activity	IDA Inferred from Direct Assay more info	PubMed
growth factor activity	TAS Traceable Author Statement more info	PubMed
hormone activity	IC Inferred by Curator more info	PubMed
hormone activity	ISS Inferred from Sequence or Structural Similarity more info
serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
type 1 angiotensin receptor binding	IPI Inferred from Physical Interaction more info	PubMed
type 2 angiotensin receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
G-protein coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
G-protein signaling, coupled to cGMP nucleotide second messenger	TAS Traceable Author Statement more info	PubMed
activation of NF-kappaB-inducing kinase activity	IEA Inferred from Electronic Annotation more info
activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	NAS Non-traceable Author Statement more info	PubMed
aging	IEA Inferred from Electronic Annotation more info
angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
angiotensin-mediated drinking behavior	IEA Inferred from Electronic Annotation more info
artery smooth muscle contraction	IEA Inferred from Electronic Annotation more info
astrocyte activation	IEA Inferred from Electronic Annotation more info
blood vessel development	IEA Inferred from Electronic Annotation more info
blood vessel remodeling	TAS Traceable Author Statement more info	PubMed
catenin import into nucleus	IEA Inferred from Electronic Annotation more info
cell growth involved in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
cell-cell signaling	TAS Traceable Author Statement more info	PubMed
cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
cellular lipid metabolic process	TAS Traceable Author Statement more info
cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
cellular sodium ion homeostasis	IEA Inferred from Electronic Annotation more info
cytokine secretion	IEA Inferred from Electronic Annotation more info
establishment of blood-nerve barrier	IEA Inferred from Electronic Annotation more info
excretion	IEA Inferred from Electronic Annotation more info
extracellular matrix organization	IEA Inferred from Electronic Annotation more info
hormone metabolic process	IEA Inferred from Electronic Annotation more info
induction of apoptosis	IEA Inferred from Electronic Annotation more info
kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
low-density lipoprotein particle remodeling	NAS Non-traceable Author Statement more info	PubMed
negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
negative regulation of nerve growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of neuron apoptosis	IEA Inferred from Electronic Annotation more info
negative regulation of tissue remodeling	IEA Inferred from Electronic Annotation more info
nitric oxide mediated signal transduction	TAS Traceable Author Statement more info	PubMed
ovarian follicle rupture	IEA Inferred from Electronic Annotation more info
peristalsis	IEA Inferred from Electronic Annotation more info
positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
positive regulation of NAD(P)H oxidase activity	TAS Traceable Author Statement more info	PubMed
positive regulation of NF-kappaB transcription factor activity	TAS Traceable Author Statement more info	PubMed
positive regulation of activation of JAK2 kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of blood pressure	IEA Inferred from Electronic Annotation more info
positive regulation of branching involved in ureteric bud morphogenesis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of calcium ion transport via voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
positive regulation of cardiac muscle hypertrophy	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of catalytic activity	IEA Inferred from Electronic Annotation more info
positive regulation of cellular protein metabolic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cholesterol esterification	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cytokine production	TAS Traceable Author Statement more info	PubMed
positive regulation of endothelial cell migration	IDA Inferred from Direct Assay more info	PubMed
positive regulation of epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
positive regulation of extracellular matrix constituent secretion	IEA Inferred from Electronic Annotation more info
positive regulation of fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
positive regulation of fibroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of inflammatory response	TAS Traceable Author Statement more info	PubMed
positive regulation of macrophage derived foam cell differentiation	IC Inferred by Curator more info	PubMed
positive regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
positive regulation of organ growth	IEA Inferred from Electronic Annotation more info
positive regulation of peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of phosphatidylinositol 3-kinase cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of reactive oxygen species metabolic process	TAS Traceable Author Statement more info	PubMed
positive regulation of renal sodium excretion	IEA Inferred from Electronic Annotation more info
positive regulation of superoxide anion generation	IEA Inferred from Electronic Annotation more info
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
regulation of blood vessel size by renin-angiotensin	TAS Traceable Author Statement more info	PubMed
regulation of blood volume by renin-angiotensin	NAS Non-traceable Author Statement more info	PubMed
regulation of cell growth	NAS Non-traceable Author Statement more info	PubMed
regulation of cell proliferation	NAS Non-traceable Author Statement more info	PubMed
regulation of long-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
regulation of norepinephrine secretion	IEA Inferred from Electronic Annotation more info
regulation of proteolysis	IBA Inferred from Biological aspect of Ancestor more info
regulation of renal output by angiotensin	NAS Non-traceable Author Statement more info	PubMed
regulation of renal sodium excretion	NAS Non-traceable Author Statement more info	PubMed
regulation of vasoconstriction	NAS Non-traceable Author Statement more info	PubMed
renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure	IEA Inferred from Electronic Annotation more info
renin-angiotensin regulation of aldosterone production	NAS Non-traceable Author Statement more info	PubMed
response to cold	IEA Inferred from Electronic Annotation more info
response to muscle activity involved in regulation of muscle adaptation	ISS Inferred from Sequence or Structural Similarity more info
response to salt stress	IEA Inferred from Electronic Annotation more info
small molecule metabolic process	TAS Traceable Author Statement more info
smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
stress-activated MAPK cascade	IEA Inferred from Electronic Annotation more info
vasodilation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasmic part	IEA Inferred from Electronic Annotation more info
extracellular region	NAS Non-traceable Author Statement more info	PubMed
extracellular region	TAS Traceable Author Statement more info
extracellular space	IC Inferred by Curator more info	PubMed
extracellular space	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISS Inferred from Sequence or Structural Similarity more info
soluble fraction	TAS Traceable Author Statement more info	PubMed

General protein information

Preferred Names: angiotensinogen

Names: angiotensinogen; serpin A8; angiotensin I; angiotensin II; pre-angiotensinogen; alpha-1 antiproteinase, antitrypsin; serine (or cysteine) proteinase inhibitor

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008836.1 RefSeqGene

Range

5001..17068

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000029.3 → NP_000020.1 angiotensinogen preproprotein

Status: REVIEWED

Source sequence(s)

AK312291, AW128887, DC412932, K02215, T97863

Consensus CDS

CCDS1585.1

UniProtKB/TrEMBL

B0ZBE2

UniProtKB/TrEMBL

B2R5S1

UniProtKB/Swiss-Prot

P01019

Related

ENSP00000355627, OTTHUMP00000035878, ENST00000366667, OTTHUMT00000092102

Conserved Domains (1) summary

cd02054
Location:105 – 481
Blast Score: 1417

angiotensinogen; Angiotensinogen is part of the renin-angiotensin system (RAS), which plays an important role in blood pressure regulation, renal haemodynamics, fluid and electrolyte homeostasis. It is also involved in normal and abnormal growth processes. The growth ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

230838269..230850336, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

201323209..201335277, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL158214.33	CAI15356.1
genomic	AL512328.16 (2000..12562)	None
genomic	AY436323.1	AAR03501.1
genomic	CH471098.1	EAW69918.1
		EAW69919.1
genomic	EU326304.1	ACA05910.1
genomic	M24689.1	AAA51679.1
genomic	S78529.1	AAD14287.1
genomic	S78530.1	AAD14288.1
genomic	X15324.1	CAA33385.1
mRNA	AB209769.1	BAD93006.1
mRNA	AK222798.1	BAD96518.1
mRNA	AK222815.1	BAD96535.1
mRNA	AK293507.1	BAG56991.1
mRNA	AK303755.1	BAG64725.1
mRNA	AK307978.1	None
mRNA	AK312291.1	BAG35218.1
mRNA	AU128714.1	None
mRNA	AW128887.1	None
mRNA	BC011519.1	AAH11519.1
mRNA	BF338744.1	None
mRNA	BT006851.1	AAP35497.1
mRNA	DC412932.1	None
mRNA	K02215.1	AAA51731.1
mRNA	M69110.1	AAA52282.1
mRNA	T97863.1	None
mRNA	W01494.1	None
other-genetic	DQ891016.2	ABM81942.1
other-genetic	DQ894196.2	ABM85122.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P01019.1	GenPept	UniProtKB/Swiss-Prot:P01019
Q53GY3	GenPept	UniProtKB/TrEMBL:Q53GY3
Q53YY1	GenPept	UniProtKB/TrEMBL:Q53YY1
Q59EP2	GenPept	UniProtKB/TrEMBL:Q59EP2
Q86U78	GenPept	UniProtKB/TrEMBL:Q86U78