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Numb numb gene homolog (Drosophila) [ Mus musculus (house mouse) ]

Gene ID: 18222, updated on 25-Aug-2015
Official Symbol
Numbprovided by MGI
Official Full Name
numb gene homolog (Drosophila)provided by MGI
Primary source
MGI:MGI:107423
See related
Ensembl:ENSMUSG00000021224; Vega:OTTMUSG00000031495
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nb
Summary
This gene encodes a conserved protein that is distributed asymmetrically during cell division in the developing embryo. The encoded protein participates in cell fate decisions by interacting with the Notch receptor. Loss of function of this gene results in severe defects in neural development and loss of viability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Orthologs
See Numb in Epigenomics, MapViewer
Location:
12; 12 D3
Exon count:
14
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 12 NC_000078.6 (83794034..83921934, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (85136389..85183293, complement)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene presenilin 1 Neighboring gene farnesyl diphosphate synthetase pseudogene Neighboring gene papilin, proteoglycan-like sulfated glycoprotein Neighboring gene endothelin converting enzyme 2 pseudogene Neighboring gene predicted gene, 31386 Neighboring gene RIKEN cDNA 2410016O06 gene Neighboring gene HEAT repeat containing 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
alpha-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adherens junction organization IGI
Inferred from Genetic Interaction
more info
PubMed 
axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lateral ventricle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuroblast division in subventricular zone IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of polarized epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
apical part of cell ISO
Inferred from Sequence Orthology
more info
 
NOT apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated vesicle ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic membrane-bounded vesicle IDA
Inferred from Direct Assay
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136075.2NP_001129547.1  protein numb homolog isoform 1

    See identical proteins and their annotated locations for NP_001129547.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1, also known as p72 or PTBL-PRRL).
    Source sequence(s)
    AC132954, AF169192, AK004553
    Consensus CDS
    CCDS49108.1
    UniProtKB/Swiss-Prot
    Q9QZS3
    Conserved Domains (2) summary
    cd01268
    Location:23168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:258339
    NumbF; NUMB domain
  2. NM_001272055.1NP_001258984.1  protein numb homolog isoform 3

    See identical proteins and their annotated locations for NP_001258984.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (3, also known as p71 or PTBS-PRRL) is shorter than isoform 1.
    Source sequence(s)
    AC132954, AF169191, AK004553
    Consensus CDS
    CCDS70401.1
    UniProtKB/Swiss-Prot
    Q9QZS3
    Conserved Domains (2) summary
    cd01268
    Location:23157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:247328
    NumbF; NUMB domain
  3. NM_001272056.1NP_001258985.1  protein numb homolog isoform 4

    See identical proteins and their annotated locations for NP_001258985.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks two alternate in-frame exons, compared to variant 1. The encoded isoform (4, also known as p65 or PTBS-PRRS) is shorter than isoform 1.
    Source sequence(s)
    AC132954, AK004553
    Consensus CDS
    CCDS70400.1
    UniProtKB/Swiss-Prot
    Q9QZS3
    Related
    ENSMUSP00000113591, OTTMUSP00000041413, ENSMUST00000117217, OTTMUST00000078037
    Conserved Domains (2) summary
    cd01268
    Location:23157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:247328
    NumbF; NUMB domain
  4. NM_010949.2NP_035079.1  protein numb homolog isoform 2

    See identical proteins and their annotated locations for NP_035079.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2, also known as p66 or PTBL-PRRS) is shorter than isoform 1.
    Source sequence(s)
    AC132954, AF170709, AK004553
    Consensus CDS
    CCDS26032.1
    UniProtKB/Swiss-Prot
    Q9QZS3
    Conserved Domains (2) summary
    cd01268
    Location:23168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:258339
    NumbF; NUMB domain

RNA

  1. NR_073563.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains three additional 5' exons and lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132954, AK004553, BY129388
  2. NR_073564.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains three additional 5' exons and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132954, AK004553, BC050108, BY129388

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p3 C57BL/6J

    Range
    83794034..83921934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515578.1XP_006515641.1  

    See identical proteins and their annotated locations for XP_006515641.1

    UniProtKB/Swiss-Prot
    Q9QZS3
    Conserved Domains (2) summary
    cd01268
    Location:23157
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:247328
    NumbF; NUMB domain
  2. XM_006515576.1XP_006515639.1  

    See identical proteins and their annotated locations for XP_006515639.1

    UniProtKB/Swiss-Prot
    Q9QZS3
    Conserved Domains (2) summary
    cd01268
    Location:23168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:258339
    NumbF; NUMB domain
  3. XM_006515572.2XP_006515635.2  

    Conserved Domains (2) summary
    cd01268
    Location:110255
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:345426
    NumbF; NUMB domain
  4. XM_006515575.2XP_006515638.2  

    Conserved Domains (2) summary
    cd01268
    Location:110244
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:334415
    NumbF; NUMB domain
  5. XM_006515573.2XP_006515636.2  

    Conserved Domains (2) summary
    cd01268
    Location:110244
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:334415
    NumbF; NUMB domain
  6. XM_006515574.2XP_006515637.2  

    Conserved Domains (2) summary
    cd01268
    Location:110255
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:345426
    NumbF; NUMB domain
  7. XM_006515577.1XP_006515640.1  

    See identical proteins and their annotated locations for XP_006515640.1

    UniProtKB/Swiss-Prot
    Q9QZS3
    Conserved Domains (2) summary
    cd01268
    Location:23168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:258339
    NumbF; NUMB domain
  8. XM_011244012.1XP_011242314.1  

    See identical proteins and their annotated locations for XP_011242314.1

    UniProtKB/Swiss-Prot
    Q9QZS3
    Conserved Domains (2) summary
    cd01268
    Location:23168
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:258339
    NumbF; NUMB domain

Alternate Mm_Celera

Genomic

  1. AC_000034.1 Alternate Mm_Celera

    Range
    85240594..85368447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)