Ntsr1 neurotensin receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ntsr1provided by MGI
Official Full Name: neurotensin receptor 1provided by MGI
Primary source: MGI:MGI:97386
See related: Ensembl:ENSMUSG00000027568 AllianceGenome:MGI:97386
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NTR1; NT-1R; NTR-1
Summary: Predicted to enable G protein-coupled neurotensin receptor activity; identical protein binding activity; and protein N-terminus binding activity. Acts upstream of or within adult locomotory behavior. Predicted to be located in several cellular components, including dendrite; perikaryon; and symmetric synapse. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; eye; gallbladder; intestine; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human NTSR1 (neurotensin receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 4.6), genital fat pad adult (RPKM 1.5) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 103.04 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (180141769..180186772)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (180499976..180544979)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of ventral tegmental area neurotensin Receptor-1 neurons promotes weight loss.
Title: Activation of ventral tegmental area neurotensin Receptor-1 neurons promotes weight loss.
Anorexia and Fat Aversion Induced by Vertical Sleeve Gastrectomy Is Attenuated in Neurotensin Receptor 1-Deficient Mice.
Title: Anorexia and Fat Aversion Induced by Vertical Sleeve Gastrectomy Is Attenuated in Neurotensin Receptor 1-Deficient Mice.
Differential allosteric modulation within dopamine D2R - neurotensin NTS1R and D2R - serotonin 5-HT2AR receptor complexes gives bias to intracellular calcium signalling.
Title: Differential allosteric modulation within dopamine D(2)R - neurotensin NTS1R and D(2)R - serotonin 5-HT(2A)R receptor complexes gives bias to intracellular calcium signalling.
Collectively, this work reveals a cellular mechanism by which neurotensi can directly engage neurotensin receptor 1-expressing DA neurons to modify dopamine signaling.
Title: Identification of Neurotensin Receptor Expressing Cells in the Ventral Tegmental Area across the Lifespan.
The weight loss behaviors are mediated by distinct signaling pathways: Nts action via NtsR1 is essential for the anorectic effect of the lateral hypothalamic Nts circuit, but not for regulation of locomotor or drinking behavior.
Title: Lateral Hypothalamic Neurotensin Neurons Orchestrate Dual Weight Loss Behaviors via Distinct Mechanisms.
Authors identified a specific subset of VTA DA neurons that express neurotensin receptor-1 (NtsR1) and preferentially comprise mesolimbic, but not mesocortical, DA neurons.
Title: Neurotensin Receptor-1 Identifies a Subset of Ventral Tegmental Dopamine Neurons that Coordinates Energy Balance.
Data demonstrate that the NTR1 can modulate the methamphetamine-induced striatal neuronal apoptosis independent of body temperature regulation. Possible mechanisms of NTR1 modulating methamphetamine-induced apoptosis include the regulation of dopamine and glutamate neurotransmission in the striatum.
Title: Pharmacological activation of the neurotensin receptor 1 abrogates the methamphetamine-induced striatal apoptosis in the mouse brain.
The roles of neurotensin and its receptor NTR-1 on sperm capacitation and acrosome reaction in mice are reported.
Title: Neurotensin enhances sperm capacitation and acrosome reaction in mice.
endogenous changes occur in NT and its receptors across multiple brain regions, and these likely support the emergence of some maternal behaviors.
Title: Endogenous CNS expression of neurotensin and neurotensin receptors is altered during the postpartum period in outbred mice.
sleep traits and a relationship between Ntsr1 and anxiety and despair behaviors in knockout mice
Title: Altered sleep and affect in the neurotensin receptor 1 knockout mouse.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (10) 1 citation
Endonuclease-mediated (2) 1 citation

General gene information

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Markers

Ntsr1 (e-PCR), detects polymorphism
- UniSTS:495994

AB017027 (e-PCR)
- UniSTS:185521

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled neurotensin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled neurotensin receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in D-aspartate import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in L-glutamate import across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in detection of temperature stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in inositol phosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of arachidonic acid secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gamma-aminobutyric acid secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inhibitory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of respiratory gaseous exchange	ISO Inferred from Sequence Orthology more info
involved_in response to lipid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in temperature homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuron spine	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in symmetric synapse	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neurotensin receptor type 1

Names: NT-R-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.